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研究業績

最終更新日 : 2017年6月15日

目次

  1. 原著論文
  2. 解説・総説や教科書など

原著論文

2017年

Koido M, Haga N, Furuno A, Tsukahara S, Sakurai J, Tani Y, Sato S, Tomida A.
Mitochondrial deficiency impairs hypoxic induction of HIF-1 transcriptional activity and retards tumor growth.
Oncotarget, 8,11841-11845, (2017)
Nagasawa I, Kunimasa K, Tsukahara S, Tomida A.
BRAF-mutated cells activate GCN2-mediated integrated stress response as a cytoprotective mechanism in response to vemurafenib.
Biochem Biophys Res Commun, 482, 1491-1497 (2017)

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2016年

Koido M, Sakurai J, Tsukahara S, Tani Y, Tomida A.
PMEPA1, a TGF-β- and hypoxia-inducible gene that participates in hypoxic gene expression networks in solid tumors.
Biochem Biophys Res Commun, 479, 615-621(2016)
Tsukumo, Y., Tsukahara, S., Furuno, A., Iemura, S.I., Natsume, T., Tomida, A.
TBL2 associates with ATF4 mRNA via its WD40 domain and regulates its translation during ER stress.
J Cell Biochem, 117, 500-509 (2016)

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2015年

Mashima, T., Ushijima, M., Matsuura, M., Tsukahara, S., Kunimasa, K., Furuno, A., Saito, S., Kitamura, M., Soma-Nagae, T., Seimiya, H., Dan, S., Yamori, T., Tomida, A.
Comprehensive transcriptomic analysis of molecularly targeted drugs in cancer for target pathway evaluation.
Cancer Sci, 106, 909-920 (2015)
Tsukumo, Y., Tsukahara, S., Furuno, A., Iemura, S., Natsume, T., Tomida, A.
The endoplasmic reticulum-localized protein TBL2 interacts with the 60S ribosomal subunit.
Biochem Biophys Res Commun, 462, 383-388 (2015)

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2014年

Matsumura, S., Yuge, R., Sato, S., Tomida, A., Ichihashi, T., Irie, H., Iijima, S., Shiba, K., Yudasaka, M.
Ultrastructural localization of intravenously injected carbon nanohorns in tumor.
Int J Nanomedicine, 9, 3499-3508 (2014)
Migita, T., Okabe, S., Ikeda, K., Igarashi, S., Sugawara, S., Tomida, A., Soga, T., Taguchi, R., Seimiya, H.
Inhibition of ATP citrate lyase induces triglyceride accumulation with altered fatty acid composition in cancer cells.
Int J Cancer, 135, 37-47 (2014)
Tsukumo, Y., Tsukahara, S., Furuno, A., Iemura, S., Natsume, T., Tomida, A.
TBL2 is a novel PERK-binding protein that modulates stress-signaling and cell survival during endoplasmic reticulum stress.
PLoS One, 9, e112761 (2014)

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2013年

Ushijima, M., Mashima, T., Tomida, A., Dan, S., Saito, S., Furuno, A., Tsukahara, S., Seimiya, H., Yamori, T., Matsuura, M.
Development of a gene expression database and related analysis programs for evaluation of anticancer compounds.
Cancer Sci, 104, 360-368 (2013)
Migita, T., Okabe, S., Ikeda, K., Igarashi, S., Sugawara, S., Tomida, A., Taguchi, R., Soga, T., Seimiya, H.
Inhibition of ATP citrate lyase induces an anticancer effect via reactive oxygen species: AMPK as a predictive biomarker for therapeutic impact.
Am J Pathol, 182, 1800-1820 (2013)

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2012年

Saito, S., Furuno, A., Sakurai, J., Park, H-R., Shin-ya, K., Tomida, A.
Compound C prevents the unfolded protein response during glucose deprivation through a mechanism independent of AMPK and BMP signaling.
PLoS ONE, 7, e45845 (2012)
Matsuo, J., Tsukumo, Y., Saito, S., Tsukahara, S., Sakurai, J., Sato, S., Kondo, H., Ushijima, M., Matsuura, M., Watanabe, T., Tomida, A.
Hyperactivation of 4E-binding protein 1 as a mediator of biguanide-induced cytotoxicity during glucose deprivation.
Mol Cancer Ther, 11, 1082-1091 (2012)

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2011年

Awale, S., Linn, T.Z., Li, F., Tezuka, Y., Myint, A., Tomida, A., Yamori, T., Esumi, H., Kadota, S.
Identification of Chrysoplenetin from Vitex negundo as a Potential Cytotoxic Agent against PANC-1 and a Panel of 39 Human Cancer Cell Lines (JFCR-39).
Phytother Res, 25, 1770-1775 (2011)
Saito, S., Tomida, A.
Use of chemical genomics in assessment of the UPR.
Methods Enzymol, 491, 327-341 (2011)

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2010年

Haga, N., Saito, S., Tsukumo, Y., Sakurai, J., Furuno, A., Tsuruo, T., Tomida, A.
Mitochondria regulate the unfolded protein response leading to cancer cell survival under glucose deprivation conditions.
Cancer Sci, 101, 1125-1132 (2010)
Kim, J.Y., Hwang, J.H., Cha, M.R., Yoon, M.Y., Son, E.S., Tomida, A., Ko, B., Song, S.W., Shin-Ya, K., Hwang, Y.I., Park, H.R.
Arctigenin blocks the unfolded protein response and shows therapeutic antitumor activity.
J Cell Physiol, 224, 33-40 (2010)
Misawa, A., Katayama, R., Koike, S., Tomida, A., Watanabe, T., Fujita, N.
AP-1-Dependent miR-21 expression contributes to chemoresistance in cancer stem cell-like SP cells.
Oncol Res, 19, 23-33 (2010)

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2009年

Arnaudeau, S., Arboit, P., Bischof, P., Shin-ya, K., Tomida, A., Tsuruo, T., Irion, O., Cohen, M.
Glucose-regulated protein 78: a new partner of p53 in trophoblast.
Proteomics, 9, 5316-5327 (2009)
Matsumura, S., Sato, S., Yudasaka, M., Tomida, A., Tsuruo, T., Iijima, S., Shiba, K.
Prevention of carbon nanohorn agglomeration using a conjugate composed of comb-shaped polyethylene glycol and a peptide aptamer.
Mol Pharm, 6, 441-447 (2009)
Matsuo, J., Tsukumo, Y., Sakurai, J., Tsukahara, S., Park, H.R., Shin-Ya, K., Watanabe, T., Tsuruo, T., Tomida, A.
Preventing the unfolded protein response via aberrant activation of 4E-binding protein 1 by versipelostatin.
Cancer Sci, 100, 327-333 (2009)
Miyawaki, J., Matsumura, S., Yuge, R., Murakami, T., Sato, S., Tomida, A., Tsuruo, T., Ichihashi, T., Fujinami, T., Irie, H., Tsuchida, K., Iijima, S., Shiba, K., Yudasaka, M.
Biodistribution and ultrastructural localization of single-walled carbon nanohorns determined in vivo with embedded Gd2O3 labels.
ACS Nano, 3, 1399-1406 (2009)
Saito, S., Furuno, A., Sakurai, J., Sakamoto, A., Park, H.R., Shin-Ya, K., Tsuruo, T., Tomida, A.
Chemical genomics identifies the unfolded protein response as a target for selective cancer cell killing during glucose deprivation.
Cancer Res, 69, 4225-4234 (2009)
Tsukumo, Y., Tsukahara, S., Saito, S., Tsuruo, T., Tomida, A.
A novel endoplasmic reticulum export signal: proline at the +2-position from the signal peptide cleavage site.
J Biol Chem, 284, 27500-27510 (2009)
Yun, J., Kim, Y.I., Tomida, A., Choi, C.H.
Regulation of DNA topoisomerase IIalpha stability by the ECV ubiquitin ligase complex.
Biochem Biophys Res Commun, 389, 5-9 (2009)

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2008年

Hwang, J.H., Kim, J.Y., Cha, M.R., Ryoo, I.J., Choo, S.J., Cho, S.M., Tsukumo, Y., Tomida, A., Shin-Ya, K., Hwang, Y.I., Yoo, I.D., Park, H.R.
Etoposide-resistant HT-29 human colon carcinoma cells during glucose deprivation are sensitive to piericidin A, a GRP78 down-regulator.
J Cell Physiol, 215, 243-250 (2008)
Isomura, M., Oya, N., Tachiiri, S., Kaneyasu, Y., Nishimura, Y., Akimoto, T., Hareyama, M., Sugita, T., Mitsuhashi, N., Yamashita, T., Aoki, M., Sai, H., Hirokawa, Y., Sakata, K., Karasawa, K., Tomida, A., Tsuruo, T., Miki, Y., Noda, T., Hiraoka, M.
IL12RB2 and ABCA1 genes are associated with susceptibility to radiation dermatitis.
Clin Cancer Res, 14, 6683-6689 (2008)
Sugita, H., Dan, S., Kong, D., Tomida, A., Yamori, T.
A new evaluation method for quantifying PI3K activity by HTRF assay.
Biochem Biophys Res Commun, 377, 941-945 (2008)
Wang, L., Bai, L., Nagasawa, T., Hasegawa, T., Yang, X., Sakai, J., Bai, Y., Kataoka, T., Oka, S., Hirose, K., Tomida, A., Tsuruo, T., Ando, M.
Bioactive triterpene saponins from the roots of Phytolacca americana.
J Nat Prod, 71, 35-40 (2008)

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2007年

Hasegawa, T., Bai, J., Dai, J., Bai, L., Sakai, J., Nishizawa, S., Bai, Y., Kikuchi, M., Abe, M., Yamori, T., Tomida, A., Tsuruo, T., Hirose, K., Ando, M.
Synthesis and structure-activity relationships of taxuyunnanine C derivatives as multidrug resistance modulator in MDR cancer cells.
Bioorg Med Chem Lett, 17, 3722-3728 (2007)
Hasegawa, T., Bai, J., Zhang, S., Wang, J., Matsubara, J., Kawakami, J., Tomida, A., Tsuruo, T., Hirose, K., Sakai, J., Kikuchi, M., Abe, M., Ando, M.
Structure-activity relationships of some taxoids as multidrug resistance modulator.
Bioorg Med Chem Lett, 17, 1122-1126 (2007)
Huang, L., Shitashige, M., Satow, R., Honda, K., Ono, M., Yun, J., Tomida, A., Tsuruo, T., Hirohashi, S., Yamada, T.
Functional interaction of DNA topoisomerase IIα with the β-catenin and T-cell factor-4 complex.
Gastroenterology, 133, 1569-1578 (2007)
Li, N., Wu, J.L., Hasegawa, T., Sakai, J., Bai, L.M., Wang, L.Y., Kakuta, S., Furuya, Y., Ogura, H., Kataoka, T., Tomida, A., Tsuruo, T., Ando, M.
Bioactive lignans from Peperomia duclouxii.
J Nat Prod, 70, 544-548 (2007)
Li, N., Wu, J.L., Hasegawa, T., Sakai, J., Bai, L.M., Wang, L.Y., Kakuta, S., Furuya, Y., Ogura, H., Kataoka, T., Tomida, A., Tsuruo, T., Ando, M.
Bioactive polyketides from Peperomia duclouxii.
J Nat Prod, 70, 998-1001 (2007)
Tsukumo, Y., Tomida, A., Kitahara, O., Nakamura, Y., Asada, S., Mori, K., Tsuruo, T.
Nucleobindin 1 controls the unfolded protein response by inhibiting ATF6 activation.
J Biol Chem, 282, 29264-29272 (2007)
Zhao, M., Bai, L., Wang, L., Toki, A., Hasegawa, T., Kikuchi, M., Abe, M., Sakai, J., Hasegawa, R., Bai, Y., Mitsui, T., Ogura, H., Kataoka, T., Oka, S., Tsushima, H., Kiuchi, M., Hirose, K., Tomida, A., Tsuruo, T., Ando, M.
Bioactive cardenolides from the stems and twigs of Nerium oleander.
J Nat Prod, 70, 1098-1103 (2007)

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2006年

Dai, J., Bai, J., Hasegawa, T., Nishizawa, S., Sakai, J., Oka, S., Kiuchi, M., Hirose, K., Tomida, A., Tsuruo, T., Li, M., Ando, M.
A new taxoid from a callus culture of Taxus cuspidata as an MDR reversal agent.
Chem Pharm Bull (Tokyo), 54, 306-309 (2006)
Li, N., Wu, J.L., Hasegawa, T., Sakai, J., Wang, L.Y., Kakuta, S., Furuya, Y., Tomida, A., Tsuruo, T., Ando, M.
Bioactive dibenzylbutyrolactone and dibenzylbutanediol lignans from Peperomia duclouxii.
J Nat Prod, 69, 234-239 (2006)
Wu, J.L., Li, N., Hasegawa, T., Sakai, J., Mitsui, T., Ogura, H., Kataoka, T., Oka, S., Kiuchi, M., Tomida, A., Tsuruo, T., Li, M., Tang, W., Ando, M.
Bioactive secolignans from Peperomia dindygulensis.
J Nat Prod, 69, 790-794 (2006)

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