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【がん研セミナー(8月28日)のお知らせ「Chromatin and Chromosomes, the Role and Function of SMC Proteins」Dr. Frank Uhlmann(Chromosome Segregation Laboratory, The Francis Crick Institute, London)】

2017年08月22日

演題:Chromatin and Chromosomes, the Role and Function of SMC Proteins

 

演者:Dr. Frank UhlmannChromosome Segregation Laboratory, The Francis Crick Institute, London)

 

抄録:Packing genomic DNA into the eukaryotic cell nucleus is a task similar to stowing the London Underground network in a suitcase. Centimetres of DNA are compacted into micrometre-sized, rod-shaped chromosomes. This allows genetic material to be made small enough for faithful segregation to opposite cell halves, and compact enough to withstand the forces generated during this process. Over the past two decades, members of the evolutionarily ancient ‘Structural Maintenance of Chromosomes (SMC)’ family of protein complexes have emerged as principal structural chromosome components. We will discuss the mechanism of how these ring-shaped protein complexes encircle DNA, helped by a loading factor whose mutation causes severe human developmental disorders. We will also discuss models of how dynamic interactions between SMC binding sites might achieve the enormous DNA packaging task, providing an image of what the inside of a chromosome might look like.

 

日時:2017年 8月 28日(月) 16:00〜17:00

 

場所:病棟新棟1階レセプションルーム

 

連絡先:広田 亨 (内線:5251)

 

*外部の研究者のご来聴を歓迎いたします。尚、本セミナーの内容は専門的であり、医学・生物分野の研究に携わる方を対象としております。

 

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