Cancer Chemotherapy Center

Innovating safe and effective anti-cancer drugs and treatments

Identification of a novel molecular target of Tivantinib (ARQ197)
Tivantinib (ARQ 197) has been developed as a small molecule c-MET inhibitor and early clinical studies suggest its effective anti-tumor activity. In this study, we newly identified microtubule polymerization-inhibiting activity of tivantinib. Our study strongly suggests that growth inhibition/cytotoxicity of tivantinib may be mainly due to inhibition of tubulin polymerization.　More

To identify molecular targets and compounds for cancer therapy

We discover and develop the novel molecular-targeted drugs by using Cancer Cell Informatics.

Telomeres, cell immortality and cancer stemness as therapeutic targets

We promote genome science-driven research for targeted therapy and personalized medicine

We focus the research between clinical samples and imaging the molecular target

Tan, T.Z., Miow, Q.H., Huang, R.Y., Wong, M.K., Ye, J., Lau, J.A., Wu, M.C., Bin Abdul Hadi, L.H., Soong, R., Choolani, M., Davidson, B., Nesland, J.M., Wang, L.Z., Matsumura, N., Mandai, M., Konishi, I., Goh, B.C., Chang, J.T., Thiery, J.P., Mori, S.

Functional genomics identifies five distinct molecular subtypes with clinical relevance and pathways for growth control in epithelial ovarian cancer.
EMBO Mol Med, (2013)
Kitano, M., Sugitani, I., Toda, K., Ikenaga, M., Motoi, N., Yamamoto, N., Hotomi, M., Fujimoto, Y., Kawabata, K.

Cytopathological review of patients that underwent thyroidectomies based on the diagnosis of papillary thyroid carcinoma by fine needle aspiration cytology but were later found to have benign tumors by histopathology.
Surg Today, in press (2012)
Uehiro, N., Horii, R., Iwase, T., Tanabe, M., Sakai, T., Morizono, H., Kimura, K., Iijima, K., Miyagi, Y., Nishimura, S., Makita, M., Ito, Y., Akiyama, F.

Validation study of the UICC TNM classification of malignant tumors, seventh edition, in breast cancer.
Breast Cancer, in press (2013)
Ueda, K., Terui, Y., Yokoyama, M., Sakajiri, S., Nishimura, N., Tsuyama, N., Takeuchi, K., Hatake, K.

Non-gastric advanced mucosa-associated lymphoid tissue (MALT) lymphoma has worse prognosis than gastric MALT lymphoma even when treated with rituximab-containing chemotherapy.
Leuk Lymphoma, in press (2013)
Ogura, K., Horii, R., Oosako, T., Iwase, T., Akiyama, F.

A clinico-pathological study on cancer in sclerosing adenosis.
Breast Cancer, in press (2013)