Cancer Chemotherapy Center

Innovating safe and effective anti-cancer drugs and treatments

The clinical trial of a new molecular-targeted drug ZSTK474, developed by Division of Molecular Pharmacology (Chief, Takao Yamori, Ph.D.) and Zenyaku Kogyo Co. Ltd., has been started. This drug inhibits PI3-kinase, which is a key enzyme for cancer growth. Preclinical studies have already demonstrated that ZSTK474 has strong anticancer activity and low toxicity. Moreover, ZSTK474 shows enhanced efficacy when combined with radiation therapy.　More

To identify molecular targets and compounds for cancer therapy

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We discover and develop the novel molecular-targeted drugs by using Cancer Cell Informatics.

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Telomeres, cell immortality and cancer stemness as therapeutic targets

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We promote genome science-driven research for targeted therapy and personalized medicine

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We focus the research between clinical samples and imaging the molecular target

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Takeuchi, K., Soda, M., Togashi, Y., Suzuki, R., Sakata, S., Hatano, S., Asaka, R., Hamanaka, W., Ninomiya, H., Uehara, H., Lim Choi, Y., Satoh, Y., Okumura, S., Nakagawa, K., Mano, H., Ishikawa, Y.

RET, ROS1 and ALK fusions in lung cancer.
Nat Med, in press (2012)
Togashi, Y., Soda, M., Sakata, S., Sugawara, E., Hatano, S., Asaka, R., Nakajima, T., Mano, H., Takeuch, K.

KLC1-ALK: A novel fusion in lung cancer identified using a formalin-fixed paraffin-embedded tissue only.
PLoS One, 7, e31323 (2012)
Goyama, S., Takeuchi, K., Kanda, Y., Nannya, Y., Chiba, S., Fukayama, M., Kurokawa, M.

Post-transplant endothelial disorder after hematopoietic SCT: a blinded autopsy study.
Bone Marrow Tansplant, in press (2011)
Yokoyama, T., Toki, T., Aoki, Y., Kanezaki, R., Park, M., Kanno, Y., Takahara, T., Yamazaki, Y., Ito, E., Hayashi, Y., Nakamura, T.

Identification of TRIB1 R107L gain-of-function mutation in human acute megakaryocytic leukemia.
Blood, in press (2012)
Sugawara, E., Togashi, Y., Kuroda, N., Sakata, S., Hatano, S., Asaka, R., Yuasa, T., Yonese, J., Kitagawa, M., Mano, H., Ishikawa, Y., Takeuchi, K.

Identification of anaplastic lymphoma kinase fusions in renal cancer.
Cancer,in press (2012)