Original articles｜Publications

Original articles

Earnshaw, W.C., Allshire, R.C., Black, B.E., Bloom, K., Brinkley, B.R., Brown, W., Cheeseman, I.M., Choo, K.H.A., Copenhaver, G.P., DeLuca, J.G., Desai, A., Diekmann, S., Erhardt, S., Fitzgerald-Hayes, M., Foltz, D., Fukagawa, T., Gassmann, R., Gerlich, D.W., Glover, D.M., Gorbsky, G.J., Harrison, S.C., Heun, P., Hirota, T., Jansen, L.E.T., Karpen, G., Kops, G.J.P., Lampson, M.A., Lens, S.M., Losada, A., Luger, K., Maiato, H., Maddox, P.S., Margolis, R.L., Masumoto, H., McAinsh, A.D., Mellone, B.G., Meraldi, P., Musacchio, A., Oegema, K., O'Neill, R.J., Salmon, E.D., Scott, K., Straight, A.F., Stukenberg, P.T., Sullivan, B.A., Sullivan, K.F., Sunkel, C.E., Swedlow, J.R., Walczak, C.E., Warburton, P.E., Westermann, S., Willard, H.F., Wordeman, L., Yanagida, M., Yen, T.J., Yoda, K., Cleveland, D.W.: Esperanto for Histones: CENP-A, not CenH3, is the centromeric histone H3 variant. Commentary.
Chromosome Res, in press (2013)
Itoh, G., Sugino, S., Mizuguchi, M., Kanno, S., Amin, M.A., Iemura, K., Ikeda, M., Yasui, A., Hirota, T., Tanaka, K.: The nucleoporin Nup188 is required for chromosome alignment in mitosis.
Cancer Sci, in press (2013)

Kumada, K., Hirota, T.: Separase. Review.
In Handbook of Proteolytic Enzymes, Rawlings, N.D., Salvesen, G., ed., (London, Elsevier), (2012)
Deardorff, M.A., Bando, M., Nakato, R., Watrin, E., Itoh, T., Minamino, M., Saitoh, K., Komata, M., Katou, Y., Clark, D., Cole, K.E., De Baere, E., Decroos, C., Di Donato, N., Ernst, S., Francey, L.J., Gyftodimou, Y., Hirashima, K., Hullings, M., Ishikawa, Y., Jaulin, C., Kaur, M., Kiyono, T., Lombardi, P.M., Magnaghi-Jaulin, L., Mortier, G.R., Nozaki, N., Petersen, M.B., Seimiya, H., Siu, V.M., Suzuki, Y., Takagaki, K., Wilde, J.J., Willems, P.J., Prigent, C., Gillessen-Kaesbach, G., Christianson, D.W., Kaiser, F.J., Jackson, L.G., Hirota, T., Krantz, I.D., Shirahige, K.: HDAC8 mutations in Cornelia de Lange syndrome affect the cohesin acetylation cycle.
Nature, 489, 313-317 (2012)
Shindo, N., Kumada, K., Hirota, T.: Separase-sensor reveals dual roles for separase coordinating cohesin cleavage and cdk1 inhibition.
Dev Cell, 23, 112-123 (2012)

*Abe, S., *Nagasaka, K., Hirayama, Y., Kozuka-Hata, H., Oyama, M., Aoyagi, Y., Obuse, C., Hirota, T., (*equal-contribution).: The initial phase of chromosome condensation requires Cdk1-mediated phosphorylation of the CAP-D3 subunit of condensin II.
Genes Dev, 25, 863-874 (2011)
Itoh, G., Kanno, S., Uchida, K.S.K., Chiba, S., Sugino, S., Watanabe, K., Mizuno, K., Yasui, A., Hirota, T., Tanaka, K.: CAMP (C13orf8, ZNF828) is a novel regulator of kinetochore-microtubule attachment.
EMBO J, 30, 130-144 (2011)
Nagasaka, K., Gallego-Paez, L.M., Hirota, T.: Mitosis and meiosis: Molecular control of chrmosome separation. Review.
In Encyclopedia of Life Sciences, (John Wiley & Sons, Ltd.), (2011)
Smith, E., Hegarat, N., Vesely, C., Roseboom, I., Streicher, H., Straataman, K., Flynn, H., Skehel, M., Hirota, T., Kuriyama, R., Hochegger, H.: Differential control of Eg5 dependent centrosome separation by Plk1 and Cdk1.
EMBO J, 30, 2233-2245 (2011)

Abe, Y., Okumura, E., Hosoya, T., Hirota, T., Kishimoto, T.: A single starfish Aurora kinase performs the combined functions of Aurora-A and Aurora-B in human cells.
J Cell Sci, 123, 3978-3988 (2010)
Arai, D., Katsura, H., Shindo, N., Matsumoto, M., Higashinakagawa, T.: Polycomb group protein Ezh1 represses Nodal and maintains the left-right axis.
Dev Biol, 341, 459-463 (2010)
Kodama, M., Otsubo, C., Hirota, T., Yokota, J., Enari, M., Taya, Y.: Requirement of ATM for rapid p53 phosphorylation at Ser46 without Ser/Thr-Gln sequences.
Mol Cell Biol, 30, 1620-1633 (2010)
Nozawa, R.S., Nagao, K., Masuda, H.T., Iwasaki, O., Hirota, T., Nozaki, N., Kimura, H., Obuse, C.: Human POGZ modulates dissociation of HP1α from mitotic chromosome arms through Aurora B activation.
Nat Cell Biol, 12, 719-727 (2010)
Ohishi, T., Hirota, T., Tsuruo, T., Seimiya, H.: TRF1 mediates mitotic abnormalities induced by Aurora-A overexpression.
Cancer Res, 70, 2041-2052 (2010)

Tanaka, K., Hirota, T.: Chromosome segregation machinery and cancer.
Cancer Sci, 100, 1158-1165 (2009)
Uchida, K.S., Takagaki, K., Kumada, K., Hirayama, Y., Noda, T., Hirota, T.: Kinetochore stretching inactivates the spindle assembly checkpoint.
J Cell Biol, 184, 383-390 (2009)
Tanuma, N., Nomura, M., Ikeda, M., Kasugai, I., Tsubaki, Y., Takagaki, K., Kawamura, T., Yamashita, Y., Sato, I., Sato, M., Katakura, R., Kikuchi, K., Shima, H.: Protein phosphatase Dusp26 associates with KIF3 motor and promotes N-cadherin-mediated cell-cell adhesion.
Oncogene, 28, 752-761 (2009)

Johnson, B.V., Shindo, N., Rathjen, P.D., Rathjen, J., Keough, R.A.: Understanding pluripotency--how embryonic stem cells keep their options open.
Mol Hum Reprod, 14, 513-520 (2008)
Matsuoka, O., Shindo, N., Arai, D., Higashinakagawa, T.: A histone H1 variant is required for erythrocyte maturation in medaka.
Int J Dev Biol, 52, 887-892 (2008)
Munirajan, A.K., Ando, K., Mukai, A., Takahashi, M., Suenaga, Y., Ohira, M., Koda, T., Hirota, T., Ozaki, T., Nakagawara, A.: KIF1Bβ functions as a haploinsufficient tumor suppressor gene mapped to chromosome 1p36.2 by inducing apoptotic cell death.
J Biol Chem, 283, 24426-24434 (2008)
Zhang, D., Shimizu, T., Araki, N., Hirota, T., Yoshie, M., Ogawa, K., Nakagata, N., Takeya, M., Saya, H.: Aurora A overexpression induces cellular senescence in mammary gland hyperplastic tumors developed in p53-deficient mice.
Oncogene, 27, 4305-4314 (2008)

Nakajima, M., Kumada, K., Hatakeyama, K., Noda, T., Peters, J.M., Hirota, T.: The complete removal of cohesin from chromosome arms depends on separase.
J Cell Sci, 120, 4188-4196 (2007)
Lipp, J.J., Hirota, T., Poser, I., Peters, J.M.: Aurora B controls the association of condensin I but not condensin II with mitotic chromosomes.
J Cell Sci, 120, 1245-1255 (2007)
Nakajima, M., Kumada, K., Hatakeyama, K., Noda, T., Peters, J.M., Hirota, T.: The complete removal of cohesin from chromosome arms depends on separase.
J Cell Sci, 120, 4188-4196 (2007)

Gerlich, D., Hirota, T., Koch, B., Peters, J.M., Ellenberg, J.: Condensin I stabilizes chromosomes mechanically through a dynamic interaction in live cells.
Curr Biol, 16, 333-344 (2006)