原著論文｜研究業績

原著論文

Takahashi, A., Imai, Y., Yamakoshi, K., Kuninaka, S., Ohtani, N., Yoshimoto, S., Hori, S., Tachibana, M., Anderton, E., Takeuchi, T., Shinkai, Y., Peters, G., Saya, H., Hara, E.: DNA Damage Signaling Triggers Degradation of Histone Methyltransferases through APC/C(Cdh1) in Senescent Cells.
Molecular cell, 45, 123-131 (2012)

Fernandez-Marcos, P.J., Pantoja, C., Gonzalez-Rodriguez, A., Martin, N., Flores, J.M., Valverde, A.M., Hara, E., Serrano, M.: Normal proliferation and tumorigenesis but impaired pancreatic function in mice lacking the cell cycle regulator sei1.
PLoS One, 5, e8744 (2010)
Kitajima, S., Miki, T., Takegami, Y., Kido, Y., Noda, M., Hara, E., Shamma, A., Takahashi, C.: Reversion-inducing cysteine-rich protein with Kazal motifs interferes with epidermal growth factor receptor signaling.
Oncogene, 30, 737-750 (2010)
Ohtani, N., Yamakoshi, K., Takahashi, A., Hara, E.: Real-time in vivo imaging of p16Ink4a gene expression: a new approach to study senescence stress signaling in living animals.
Cell Div, 5, 1 (2010)
Takeuchi, S., Takahashi, A., Motoi, N., Yoshimoto, S., Tajima, T., Yamakoshi, K., Hirano, A., Yanagi, S., Fukami, K., Ishikawa, Y., Sone, S., Hara, E., Ohtani, N.: Intrinsic cooperation between p16INK4a and p21Waf1/Cip1 in the onset of cellular senescence and tumor suppression in vivo.
Cancer Res, 70, 9381-9390 (2010)

Inomata, K., Aoto, T., Binh, N.T., Okamoto, N., Tanimura, S., Wakayama, T., Iseki, S., Hara, E., Masunaga, T., Shimizu, H., Nishimura, E.K.: Genotoxic stress abrogates renewal of melanocyte stem cells by triggering their differentiation.
Cell, 137, 1088-1099 (2009)
Yamakoshi, K., Takahashi, A., Hirota, F., Nakayama, R., Ishimaru, N., Kubo, Y., Mann, D.J., Ohmura, M., Hirao, A., Saya, H., Arase, S., Hayashi, Y., Nakao, K., Matsumoto, M., Ohtani, N., Hara, E.: Real-time in vivo imaging of p16Ink4a reveals cross talk with p53.
J Cell Biol, 186, 393-407 (2009)

Ohtani, N., Imamura, Y., Yamakoshi, K., Hirota, F., Nakayama, R., Kubo, Y., Ishimaru, N., Takahashi, A., Hirao, A., Shimizu, T., Mann, D.J., Saya, H., Hayashi, Y., Arase, S., Matsumoto, M., Kazuki, N., Hara, E.: Visualizing the dynamics of p21(Waf1/Cip1) cyclin-dependent kinase inhibitor expression in living animals.
Proc Natl Acad Sci U S A, 104, 15034-15039 (2007)

Takahashi, A., Ohtani, N., Yamakoshi, K., Iida, S., Tahara, H., Nakayama, K., Nakayama, K.I., Ide, T., Saya, H., Hara, E.: Mitogenic signalling and the p16INK4a-Rb pathway cooperate to enforce irreversible cellular senescence.
Nat Cell Biol, 8, 1291-1297 (2006)

Maehara, K., Yamakoshi, K., Ohtani, N., Kubo, Y., Takahashi, A., Arase, S., Jones, N., Hara, E.: Reduction of total E2F/DP activity induces senescence-like cell cycle arrest in cancer cells lacking functional pRB and p53.
J Cell Biol, 168, 553-560 (2005)

Ohtani, N., Zebedee, Z., Huot, T.J., Stinson, J.A., Sugimoto, M., Ohashi, Y., Sharrocks, A.D., Peters, G., Hara, E.: Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence.
Nature, 409, 1067-1070 (2001)