最終更新日 :
2022年4月14日
目次
原著論文
2021年｜2020年｜2019年｜2018年｜2016年｜2015年｜2014年｜2013年｜2012年｜2011年｜2010年｜2009年｜2008年｜2007年｜2006年
2021年
- Uchida, KSK., Jo, M., Nagasaka, K., Takahashi, M., Shindo, N., Shibata, K., Tanaka, K., Masumoto, H., Fukagawa, T., and Hirota, T.
- Kinetochore stretching-mediated rapid silencing of the spindle-assembly checkpoint required for failsafe chromosome segregation.
Curr. Biol, 31: 1581-1591 (2021) - Shindo, N., Otsuki, M., Uchida, KSK., and Hirota, T.
- Prolonged mitosis causes separase deregulation and chromosome nondisjunction.
Cell Rep, 34: 108652 (2021) - Matsui, S., and Nozawa, R.S.
- RNA impacts formation of biomolecular condensates in the nucleus.
Biomed. Res, 42: 153-160 (2021) - Yoshida, R., Hagio, T., Kaneyasu, T., Gotoh, O., Osako, T., Tanaka, N., Amino, S., Yaguchi, N., Nakashima, E., Kitagawa, D., Ueno, T., Ohno, S., Nakajima, T., Nakamura, S., Miki, Y., Hirota, T., Takahashi, S., Matsuura, M., Noda, T., and Mori, S.
- Pathogenicity assessment of variants for breast cancer susceptibility genes based on BRCAness of tumor sample.
Cancer Sci, 112: 1310-1319 (2021) - Miyata, K., Imai, Y., Hori, S., Nishio, M., Loo, T.M., Okada, R., Yang, L., Nakadai, T., Maruyama, R., Fujii, R., Ueda, K., Jiang, Li., Zheng, H., Toyokuni, S., Sakata, T., Shirahige, K., Kojima, R., Nakayama, M., Oshima, M., Nagayama, S., Seimiya, H., Hirota, T., Saya, H., Hara, E. and Takahashi, A.
- Pericentromeric noncoding RNA changes DNA binding of CTCF and inflammatory gene expression in senescence and cancer.
Proc. Natl. Acad. Sci. USA, 118: e2025647118 (2021) - Rii, J., Sakamoto, S., Sugiura, M., Kanesaka, M., Fujimoto, A., Yamada, Y., Maimaiti, M., Ando, K., Wakai, K., Xu, M., Imamura, Y., Shindo, N., Hirota, T., Kaneda, A., Kanai, Y., Ikehara, Y., Anzai, N., Ichikawa, T.
- Functional analysis of LAT3 in prostate cancer: its downstream target and relationship with androgen receptor.
Cancer Sci, 112: 3871-3883 (2021)
2020年
- Fujimura, A., Hayashi, Y., Kato, K., Kogure, Y., Kameyama, M., Shimamoto, H., Daitoku, H., Fukamizu, A., Hirota, T., Kimura, K.
- Identification of a novel nucleolar protein complex required for mitotic chromosome segregation through centromeric accumulation of Aurora B.
Nucleic Acids Res. 48: 6583-6596 (2020) - Watson, N.A., Cartwright, T.N., Lawless, C., Camara-Donoso, M., Sen, O., Sako, K., Hirota, T., Kimura, H., Higgins, J.M.G.
- Kinase iinhibition profiles as a tool to identify kinases for specific phosphorylation sites.
Nature Commun. 11: 1684 doi: 10.1038/s41467-020-15428-0 (2020) - Boteva, L., Nozawa, R. S., Naughton, C., Samejima, K., Earnshaw, W. C., Gilbert, N.
- Common fragile sites are characterized by faulty condensin loading after replication stress.
Cell Rep. 32 (12) 108177 (2020) - Kinjo, K., Nagasaki, K., Muroya, K., Suzuki, E., Ishiwata, K., Nakabayashi, K., Hattori, A., Nagao, K., Nozawa, R. S., Obuse, C., Miyado, K., Ogata, T., Fukami, M., and Miyado, M.
- Rare variant of the epigenetic regulator SMCHD1 in a patient with pituitary hormone deficiency.
Sci. Rep. 10: 10985 (2020)
2019年
- Nishibuchi, G., Machida, S., Nakagawa, R., Yoshimura, Y., Hiragami-Hamada, K., Abe, Y., Kurumizaka, H., Tagami, H., and Nakayama, J. I.
- Mitotic phosphorylation of HP1α regulates its cell cycle-dependent chromatin binding.
J. Biochem. 165: 433-446 (2019) - Nishimura, K., Johmura, Y., Deguchi, K., Jiang, Z., Uchida, KSK., Suzuki, N., Shimada, M., Chiba, Y., Hirota, T., Yoshimura, SH., Kono, K,. Nakanish, M.
- Cdk1-mediated DIAPH1 phosphorylation maintains metaphase cortical tension and inactivates the spindle assembly checkpoint at anaphase.
Nature Commun. 10: 981-993 (2019) - Nakayama, I., Shinozaki, E., Sakata, S., Yamamoto, N., Fujisaki, J., Muramatsu, Y., Hirota, T., Takeuchi, K., Takahashi, S., Yamaguchi, K., Noda, T.
- Enrichment of CLDN18-ARHGAP fusion gene in gastric cancers in young adults.
Cancer Sci. 110: 1352-1363 (2019)
2018年
- Konishi, M., Shindo, N., Komiya, M., Tanaka, K., Itoh, T. and Hirota, T.
- Quantitative analyses of the metaphase-to-anaphase transition reveal differential kinetic regulation for securin and cyclin B1.
Biomed Res. 39: 75-85 (2018) - Takahashi, M., and Hirota, T.
- Dynamics of sister chromatids through the cell cycle: Together and apart. Spotlight.
J Cell Biol. 217: 1887-1889 (2018) - Hayashi, Y., Fujimura, A., Kato, K., Udagawa, R., Hirota, T., and Kimura, K.
- Nucleolar integrity during interphase supports faithful Cdk1 activation and mitotic entry.
Sci Adv. 4: eaap7777 (2018)
2016年
- Y. Abe and T. Hirota.
- System-level deficiencies in Aurora B control in cancers.
Cell cycle, 15, 2091-2092 (2016) - Y. Abe, K. Sako, K. Takagaki, Y. Hirayama, K. S. Uchida, J. A. Herman, J. G. DeLuca and T. Hirota.
- HP1-assisted aurora B kinase activity prevents chromosome segregation errors.
Developmental cell, 36, 487-97 (2016) - K. Nagasaka, M. J. Hossain, M. J. Roberti, J. Ellenberg and T. Hirota.
- Sister chromatid resolution is an intrinsic part of chromosome organization in prophase.
Nature cell biology, 18, 692-9 (2016) - M. Takahashi, K. Tanaka, T. Wakai and T. Hirota.
- Phosphoproteomic analysis of human mitotic chromosomes identified a chromokinesin KIF4A.
Biomedical research, 37, 161-5 (2016) - M. Takahashi, T. Wakai and T. Hirota.
- Condensin I-mediated mitotic chromosome assembly requires association with chromokinesin KIF4A.
Genes & development, 30, 1931-6 (2016) - K. Tanaka and T. Hirota.
- Chromosomal instability: A common feature and a therapeutic target of cancer.
Biochimica et biophysica acta, 1866, 64-75 (2016)
2015年
- Minamino, M., Ishibashi, M., Nakato, R., Akiyama, K., Tanaka, H., Kato, Y., Negishi, L., Hirota, T., Sutani, T., Bando, M., Shirahige, K.
- Esco1 acetylates cohesin via a mechanism different from that of Esco2.
Curr Biol, 25, 1694-1706 (2015) - Nagasaka, K., Hirota, T.
- Clarifying the role of condensin in shaping chromosomes.
Nat Cell Biol, 17, 711-713 (2015)
2014年
- Gallego-Paez, L.M., Tanaka, H., Bando, M., Takahashi, M., Nozaki, N., Nakato, R., Shirahige, K., Hirota, T.
- Smc5/6-mediated regulation of replication progression contributes to chromosome assembly during mitosis in human cells.
Mol Biol Cell, 25, 302-317 (2014)
2013年
- Earnshaw, W.C., Allshire, R.C., Black, B.E., Bloom, K., Brinkley, B.R., Brown, W., Cheeseman, I.M., Choo, K.H.A., Copenhaver, G.P., DeLuca, J.G., Desai, A., Diekmann, S., Erhardt, S., Fitzgerald-Hayes, M., Foltz, D., Fukagawa, T., Gassmann, R., Gerlich, D.W., Glover, D.M., Gorbsky, G.J., Harrison, S.C., Heun, P., Hirota, T., Jansen, L.E.T., Karpen, G., Kops, G.J.P., Lampson, M.A., Lens, S.M., Losada, A., Luger, K., Maiato, H., Maddox, P.S., Margolis, R.L., Masumoto, H., McAinsh, A.D., Mellone, B.G., Meraldi, P., Musacchio, A., Oegema, K., O'Neill, R.J., Salmon, E.D., Scott, K., Straight, A.F., Stukenberg, P.T., Sullivan, B.A., Sullivan, K.F., Sunkel, C.E., Swedlow, J.R., Walczak, C.E., Warburton, P.E., Westermann, S., Willard, H.F., Wordeman, L., Yanagida, M., Yen, T.J., Yoda, K., Cleveland, D.W.
- Esperanto for Histones: CENP-A, not CenH3, is the centromeric histone H3 variant. Commentary.
Chromosome Res, 21, 101-106 (2013) - Itoh, G., Sugino, S., Mizuguchi, M., Kanno, S., Amin, M.A., Iemura, K., Ikeda, M., Yasui, A., Hirota, T., Tanaka, K.
- The nucleoporin Nup188 is required for chromosome alignment in mitosis.
Cancer Sci, 104, 871-879 (2013) - Ando, K., Ozaki, T., Hirota, T., Nakagawara, A.
- NFBD1/MDC1 Is Phosphorylated by PLK1 and Controls G2/M Transition through the Regulation of a TOPOIIalpha-Mediated Decatenation Checkpoint.
PLoS One, 8, e82744 (2013)
2012年
- Kumada, K., Hirota, T.
- Separase. Review.
In Handbook of Proteolytic Enzymes, Rawlings, N.D., Salvesen, G., ed., (London, Elsevier), (2012) - Deardorff, M.A., Bando, M., Nakato, R., Watrin, E., Itoh, T., Minamino, M., Saitoh, K., Komata, M., Katou, Y., Clark, D., Cole, K.E., De Baere, E., Decroos, C., Di Donato, N., Ernst, S., Francey, L.J., Gyftodimou, Y., Hirashima, K., Hullings, M., Ishikawa, Y., Jaulin, C., Kaur, M., Kiyono, T., Lombardi, P.M., Magnaghi-Jaulin, L., Mortier, G.R., Nozaki, N., Petersen, M.B., Seimiya, H., Siu, V.M., Suzuki, Y., Takagaki, K., Wilde, J.J., Willems, P.J., Prigent, C., Gillessen-Kaesbach, G., Christianson, D.W., Kaiser, F.J., Jackson, L.G., Hirota, T., Krantz, I.D., Shirahige, K.
- HDAC8 mutations in Cornelia de Lange syndrome affect the cohesin acetylation cycle.
Nature, 489, 313-317 (2012) - Shindo, N., Kumada, K., Hirota, T.
- Separase-sensor reveals dual roles for separase coordinating cohesin cleavage and cdk1 inhibition.
Dev Cell, 23, 112-123 (2012)
2011年
- *Abe, S., *Nagasaka, K., Hirayama, Y., Kozuka-Hata, H., Oyama, M., Aoyagi, Y., Obuse, C., Hirota, T., (*equal-contribution).
- The initial phase of chromosome condensation requires Cdk1-mediated phosphorylation of the CAP-D3 subunit of condensin II.
Genes Dev, 25, 863-874 (2011) - Itoh, G., Kanno, S., Uchida, K.S.K., Chiba, S., Sugino, S., Watanabe, K., Mizuno, K., Yasui, A., Hirota, T., Tanaka, K.
- CAMP (C13orf8, ZNF828) is a novel regulator of kinetochore-microtubule attachment.
EMBO J, 30, 130-144 (2011) - Nagasaka, K., Gallego-Paez, L.M., Hirota, T.
- Mitosis and meiosis: Molecular control of chrmosome separation. Review.
In Encyclopedia of Life Sciences, (John Wiley & Sons, Ltd.), (2011) - Smith, E., Hegarat, N., Vesely, C., Roseboom, I., Streicher, H., Straataman, K., Flynn, H., Skehel, M., Hirota, T., Kuriyama, R., Hochegger, H.
- Differential control of Eg5 dependent centrosome separation by Plk1 and Cdk1.
EMBO J, 30, 2233-2245 (2011)
2010年
- Abe, Y., Okumura, E., Hosoya, T., Hirota, T., Kishimoto, T.
- A single starfish Aurora kinase performs the combined functions of Aurora-A and Aurora-B in human cells.
J Cell Sci, 123, 3978-3988 (2010) - Arai, D., Katsura, H., Shindo, N., Matsumoto, M., Higashinakagawa, T.
- Polycomb group protein Ezh1 represses Nodal and maintains the left-right axis.
Dev Biol, 341, 459-463 (2010) - Kodama, M., Otsubo, C., Hirota, T., Yokota, J., Enari, M., Taya, Y.
- Requirement of ATM for rapid p53 phosphorylation at Ser46 without Ser/Thr-Gln sequences.
Mol Cell Biol, 30, 1620-1633 (2010) - Nozawa, R.S., Nagao, K., Masuda, H.T., Iwasaki, O., Hirota, T., Nozaki, N., Kimura, H., Obuse, C.
- Human POGZ modulates dissociation of HP1α from mitotic chromosome arms through Aurora B activation.
Nat Cell Biol, 12, 719-727 (2010) - Ohishi, T., Hirota, T., Tsuruo, T., Seimiya, H.
- TRF1 mediates mitotic abnormalities induced by Aurora-A overexpression.
Cancer Res, 70, 2041-2052 (2010)
2009年
- Tanaka, K., Hirota, T.
- Chromosome segregation machinery and cancer.
Cancer Sci, 100, 1158-1165 (2009) - Uchida, K.S., Takagaki, K., Kumada, K., Hirayama, Y., Noda, T., Hirota, T.
- Kinetochore stretching inactivates the spindle assembly checkpoint.
J Cell Biol, 184, 383-390 (2009) - Tanuma, N., Nomura, M., Ikeda, M., Kasugai, I., Tsubaki, Y., Takagaki, K., Kawamura, T., Yamashita, Y., Sato, I., Sato, M., Katakura, R., Kikuchi, K., Shima, H.
- Protein phosphatase Dusp26 associates with KIF3 motor and promotes N-cadherin-mediated cell-cell adhesion.
Oncogene, 28, 752-761 (2009)
2008年
- Johnson, B.V., Shindo, N., Rathjen, P.D., Rathjen, J., Keough, R.A.
- Understanding pluripotency--how embryonic stem cells keep their options open.
Mol Hum Reprod, 14, 513-520 (2008) - Matsuoka, O., Shindo, N., Arai, D., Higashinakagawa, T.
- A histone H1 variant is required for erythrocyte maturation in medaka.
Int J Dev Biol, 52, 887-892 (2008) - Munirajan, A.K., Ando, K., Mukai, A., Takahashi, M., Suenaga, Y., Ohira, M., Koda, T., Hirota, T., Ozaki, T., Nakagawara, A.
- KIF1Bβ functions as a haploinsufficient tumor suppressor gene mapped to chromosome 1p36.2 by inducing apoptotic cell death.
J Biol Chem, 283, 24426-24434 (2008) - Zhang, D., Shimizu, T., Araki, N., Hirota, T., Yoshie, M., Ogawa, K., Nakagata, N., Takeya, M., Saya, H.
- Aurora A overexpression induces cellular senescence in mammary gland hyperplastic tumors developed in p53-deficient mice.
Oncogene, 27, 4305-4314 (2008)
2007年
- Nakajima, M., Kumada, K., Hatakeyama, K., Noda, T., Peters, J.M., Hirota, T.
- The complete removal of cohesin from chromosome arms depends on separase.
J Cell Sci, 120, 4188-4196 (2007) - Lipp, J.J., Hirota, T., Poser, I., Peters, J.M.
- Aurora B controls the association of condensin I but not condensin II with mitotic chromosomes.
J Cell Sci, 120, 1245-1255 (2007) - Nakajima, M., Kumada, K., Hatakeyama, K., Noda, T., Peters, J.M., Hirota, T.
- The complete removal of cohesin from chromosome arms depends on separase.
J Cell Sci, 120, 4188-4196 (2007)
2006年
- Gerlich, D., Hirota, T., Koch, B., Peters, J.M., Ellenberg, J.
- Condensin I stabilizes chromosomes mechanically through a dynamic interaction in live cells.
Curr Biol, 16, 333-344 (2006)
