原著論文｜研究業績

原著論文

Abe, S., Nagasaka, K., Hirayama, Y., Kozuka-Hata, H., Oyama, M., Aoyagi, Y., Obuse, C., Hirota, T., (*equal-contribution).: The initial phase of chromosome condensation requires Cdk1-mediated phosphorylation of the CAP-D3 subunit of condensin II.
Genes Dev, 25, 863-874 (2011)
Itoh, G., Kanno, S., Uchida, K. S., Chiba, S., Sugino, S., Watanabe, K., Mizuno, K., Yasui, A., Hirota, T., Tanaka, K.: CAMP (C13orf8, ZNF828) is a novel regulator of kinetochore-microtubule attachment.
EMBO J, 30, 130-144 (2011)
Nagasaka, K., Gallego-Paez, L.M., Hirota, T.: Mitosis and meiosis: Molecular control of chrmosome separation. Review.
In Encyclopedia of Life Sciences, (John Wiley & Sons, Ltd.), (2011)
Smith, E., Hegarat, N., Vesely, C., Roseboom, I., Streicher, H., Straataman, K., Flynn, H., Skehel, M., Hirota, T., Kuriyama, R., Hochegger, H.: Differential control of Eg5 dependent controsome separation by Plk1 and Cdk1.
EMBO J, in press (2011)

Abe, Y., Okumura, E., Hosoya, T., Hirota, T., Kishimoto, T.: A single starfish Aurora kinase performs the combined functions of Aurora-A and Aurora-B in human cells.
J Cell Sci, 123, 3978-3988 (2010)
Arai, D., Katsura, H., Shindo, N., Matsumoto, M., Higashinakagawa, T.: Polycomb group protein Ezh1 represses Nodal and maintains the left-right axis.
Dev Biol, 341, 459-463 (2010)
Kodama, M., Otsubo, C., Hirota, T., Yokota, J., Enari, M., Taya, Y.: Requirement of ATM for rapid p53 phosphorylation at Ser46 without Ser/Thr-Gln sequences.
Mol Cell Biol, 30, 1620-1633 (2010)
Nozawa, R.S., Nagao, K., Masuda, H.T., Iwasaki, O., Hirota, T., Nozaki, N., Kimura, H., Obuse, C.: Human POGZ modulates dissociation of HP1α from mitotic chromosome arms through Aurora B activation.
Nat Cell Biol, 12, 719-727 (2010)
Ohishi, T., Hirota, T., Tsuruo, T., Seimiya, H.: TRF1 mediates mitotic abnormalities induced by Aurora-A overexpression.
Cancer Res, 70, 2041-2052 (2010)

Tanaka, K., Hirota, T.: Chromosome segregation machinery and cancer.
Cancer Sci, 100, 1158-1165 (2009)
Uchida, K.S., Takagaki, K., Kumada, K., Hirayama, Y., Noda, T., Hirota, T.: Kinetochore stretching inactivates the spindle assembly checkpoint.
J Cell Biol, 184, 383-390 (2009)
Tanuma, N., Nomura, M., Ikeda, M., Kasugai, I., Tsubaki, Y., Takagaki, K., Kawamura, T., Yamashita, Y., Sato, I., Sato, M., Katakura, R., Kikuchi, K., Shima, H.: Protein phosphatase Dusp26 associates with KIF3 motor and promotes N-cadherin-mediated cell-cell adhesion.
Oncogene, 28, 752-761 (2009)

Johnson, B.V., Shindo, N., Rathjen, P.D., Rathjen, J., Keough, R.A.: Understanding pluripotency--how embryonic stem cells keep their options open.
Mol Hum Reprod, 14, 513-520 (2008)
Matsuoka, O., Shindo, N., Arai, D., Higashinakagawa, T.: A histone H1 variant is required for erythrocyte maturation in medaka.
Int J Dev Biol, 52, 887-892 (2008)
Munirajan, A.K., Ando, K., Mukai, A., Takahashi, M., Suenaga, Y., Ohira, M., Koda, T., Hirota, T., Ozaki, T., Nakagawara, A.: KIF1Bβ functions as a haploinsufficient tumor suppressor gene mapped to chromosome 1p36.2 by inducing apoptotic cell death.
J Biol Chem, 283, 24426-24434 (2008)
Zhang, D., Shimizu, T., Araki, N., Hirota, T., Yoshie, M., Ogawa, K., Nakagata, N., Takeya, M., Saya, H.: Aurora A overexpression induces cellular senescence in mammary gland hyperplastic tumors developed in p53-deficient mice.
Oncogene, 27, 4305-4314 (2008)

Nakajima, M., Kumada, K., Hatakeyama, K., Noda, T., Peters, J.M., Hirota, T.: The complete removal of cohesin from chromosome arms depends on separase.
J Cell Sci, 120, 4188-4196 (2007)
Lipp, J.J., Hirota, T., Poser, I., Peters, J.M.: Aurora B controls the association of condensin I but not condensin II with mitotic chromosomes.
J Cell Sci, 120, 1245-1255 (2007)
Nakajima, M., Kumada, K., Hatakeyama, K., Noda, T., Peters, J.M., Hirota, T.: The complete removal of cohesin from chromosome arms depends on separase.
J Cell Sci, 120, 4188-4196 (2007)

Gerlich, D., Hirota, T., Koch, B., Peters, J.M., Ellenberg, J.: Condensin I stabilizes chromosomes mechanically through a dynamic interaction in live cells.
Curr Biol, 16, 333-344 (2006)