Outline Director's Room Experimental Chemotherapy Molecular Phamacology Molecular Biotherapy Genome Research Clinical Research Anticancer Drug Information Office (ADIO) Genatherapy

To the homepage of part management Our laboratory has started research activities since January 2005, aiming to study the effectiveness of molecular-targeted anticancer drugs at the genome level. Our goals are to develop diagnosis methods for predicting drug responsiveness in cancer patients and to search new molecular targets for tumor-selective therapy. For the attainment of the purpose, we promote two projects, using genome technologies: 1) translational research for diagnosis of drug responsiveness in molecular-targeted therapy and 2) basic research for microenvironment-oriented, molecular-targeted therapy. The feature of the first project is to conduct gene expression analysis of tumor cells, in parallel with clinical trials of investigational new drugs, especially molecular-targeted drugs. The feature of the second project is to study the adaptive response of cancer cells under solid tumor-related stress conditions (e.g., hypoxia and glucose deprivation), aiming to identify possible therapeutic targets. Through these researches, we hope to contribute to the achievement of the personalized medicine and the development of a tumor-selective therapeutic agent. (1) Translational research for diagnosis of drug responsiveness in molecular-targeted therapy (2) Basic research for microenvironment-oriented, molecular-targeted therapy Chief Akihiro Tomida Staff Scientist Naomi Haga Postdoctoral Scientist Sakae Saito, Yoshinori Tsukumo Staff Technician Junko Sakurai, Satomi Tsukahara Technician Aki Furuno Visiting Scientist Tadashi Nakamura, Hiromichi Kondo, Kounosuke Hayashi Visiting Ph.D. Student Junichi Matsuo