Outline Director's Room Experimental Chemotherapy Molecular Phamacology Molecular Biotherapy Genome Research Clinical Research Anticancer Drug Information Office (ADIO) Genatherapy

The goals of Molecular Biotherapy are to clarify the details of molecular mechanisms for maintenance of chromosome ends, telomeres, in cancer cells and to establish a novel cancer therapy that targets the telomere maintenance system. At the level of basic science, our effort is mainly concentrated on mechanisms for functional regulation of telomerase and tankyrase 1, both of which are involved in telomere maintenance. At the level of applied research, we are working on development of telomerase inhibitors and verification of their efficacy, and combination therapy for more dramatic ant-cancer therapeutic effects. (1) Molecular mechanisms for telomere length regulation (2) Molecular targeting cancer therapy by telomerase inhibitors (3) Physiological functions and regulation mechanism of tankyrase 1 Chief Hiroyuki Seimiya Staff Scientist Tetsuo Mashima, Toshiro Migita Postdoctoral Scientist Tomokazu Ohishi, Kyotaro Hirashima Visiting Master Student Kaori Hatsugai, Satoshi Tokunaga Staff Technician Yukiko Muramatsu Technician Sachiko Okabe Visiting Scientist Shinichi Torii Visiting Undergraduate Student Akiko Hamada