Outline Director's Room Pathology Cell Biology Biochemistry Experimental Pathology Cancer Biology Carcinogenesis Genetic Diagnosis Protein Engineering Epigenetic Carcinogenesis Cancer Genomics Physics Chemotherapy

Our laboratory has been interested in molecular and fundamental mechanisms of carcinogenesis. Research is focused on hematological and mesenchymal malignancies and oncogenic transcription factors. These studies are achieved by using genetical approach and mouse models. We use retrovirus induced mouse models and genetically engineered models, and these models are valuable tools to identify novel disease genes, to understand molecular pathways of diseases and to search diagnostic and therapeutic application. (1) The role of homeobox genes in hematological malignancies (2) Identification of novel chimeras in human malignancies (3) Retroviral insertional mutagenesis and analysis of NUP98-HOXA9 chimera (4) Functional analysis of Evi9/BCL11A (5) Identification of targets for chimeric transcription factors Chief Takuro Nakamura Staff Scientist Yuichi Wakabayashi Postdoctoral Scientist Miwa Tanaka, Takashi Yokoyama Attending Scientist Takashi Fujino Visiting Scientist Morito Kurata Visiting Ph.D. Student Yoshinobu Komai Master Student Moriyasu Nakaema Staff Technician Yukari Yamazaki, Tomoko Takahara Technician Yohei Kanno Management Assistant Hisako Hirano