Outline Director's Room Pathology Cell Biology Biochemistry Experimental Pathology Cancer Biology Carcinogenesis Genetic Diagnosis Protein Engineering Epigenetic Carcinogenesis Cancer Genomics Physics Chemotherapy

>>Division's Original Web Site Cellular senescence is a state of permanent cell cycle arrest that can be induced by a variety of potentially oncogenic stresses. It is therefore proposed as a fail-safe mechanism that protects normal cells from losing control of cell division and forming tumours. Our major focus is the understanding of the signalling pathways that induce cellular senescence and to elucidate how these pathways are blocked in cancer cells. We hope that these studies will provide new insights into the development of cancer and open up new possibilities for its control. (1) Regulation of INK4a/ARF gene locus in tumor suppression (2) Irreversibility of cellular senescence (3) Real-time imaging of senescence signaling in living animals Chief Eiji Hara Senior Staff Scientist Naoko Ohtani Staff Scientist Akiko Takahashi Postdoctoral Scientist Kimi Yamakoshi, Shin Yoshimoto Visiting Ph.D. Student Shinji Takeuchi Technician Chizuru Sugita Visiting Undergraduate Student Yoshinori Imai, Tomoko Tajima Management Assistant Satoko Ootomi