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【がん研先端研究セミナー(11月11日)のお知らせ「Impact of cellular senescence on cellular plasticity and tissue regeneration 」Han Li博士(パスツール研究所)】

2016年10月04日

がん研先端研究セミナー(11月11日)のお知らせ

 

演題:Impact of cellular senescence on cellular plasticity and tissue regeneration

 

演者:Han Li博士(パスツール研究所)

 

抄録:In vivo reprogramming is an emerging strategy for tissue repair, while senescence has been proposed to promote regeneration. However, it is unknown whether senescence could facilitate the reprogramming process during tissue repair and regeneration. Here we find that senescence induced by tissue damage is critical for in vivo reprogramming in both acute and chronic skeletal muscle injury models in mice. Using Pax7-specific lineage tracing model, we demonstrate that muscle stem cells are the cell of origin for in vivo reprogramming. Interestingly, in vivo reprogramming occurs faster in aged mice (2 years) than young mice (2 month) upon acute muscle injury, mostly due to the age-dependent accumulation of senescent cells. Moreover, by blocking IL-6, an important component of senescence-associated secretory phenotype (SASP), we successfully hindered in vivo reprogramming, clearly linking senescence to the effects of injury on cellular plasticity. These findings provide a fascinating extension of our understanding of how senescence is beneficial for tissue regeneration.

 

日時:2016年11月11日(金) 15:00〜16:00

 

場所:研究所3F 病理セミナー室

 

連絡先:原英二(内線:5351)

 

*外部の研究者のご来聴を歓迎いたします。尚、本セミナーの内容は専門的であり、医学・生物分野の研究に携わる方を対象としております。

 

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