がん研セミナー（10月1７日）のお知らせ

演題：Potent anti-tumor effects of IL-7/CCL19-producing CAR-T cells against solid tumors

演者：玉田 耕治 博士（山口大学 大学院医学系研究科 免疫学講座・教授）

抄録：For effective CAR-T cell therapy against solid tumors, we have developed novel technology which enables CAR-T cells to simultaneously produce interleukin-7 (IL-7) and CCL19, aiming at efficient accumulation, expansion, and survival of immune cells inside solid tumor tissues. Treatment of pre-established solid tumors with IL-7/CCL19-producing CAR-T cells achieved complete regression followed by prolonged mouse survival and long-term memory response specific to tumor. Tumor tissues from the mice treated with IL-7/CCL19-producing CAR-T cells demonstrated massive accumulation of immune cells including both the transferred CAR-T cells and endogenous T cells and DC. Potential of further application of gene-modified T cells producing cytokines/chemokines or other immune-modulators will be discussed.

日時：２０１９年１０月１７日（木） １６：００〜１７：００

場所：吉田記念講堂

連絡先：竹本 愛（内線５７１４）

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