最終更新日 : 2017年6月13日


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K. Hosoya, S. Matsusaka, T. Kashiwada, K. Suzuki, N. Ureshino, A. Sato, Y. Miki, K. Kitera, M. Hirai, K. Hatake, S. Kimura and N. Sueoka-Aragane.
Detection of KRAS Mutations in Plasma DNA Using a fully Automated Rapid Detection System in Colorectal Cancer Patients.
Pathology oncology research, in press (2017)
C. T. Nguyen, T. Okamura, K. I. Morita, S. Yamaguchi, H. Harada, Y. Miki, T. Izumo, K. Kayamori, A. Yamaguchi and K. Sakamoto.
LAMC2 is a predictive marker for the malignant progression of leukoplakia.
Journal of oral pathology & medicine, 46, 223-231 (2017)
M. Takaoka, S. Ito, Y. Miki and A. Nakanishi.
FKBP51 regulates cell motility and invasion via RhoA signaling.
Cancer Science, 108, 380-389 (2017)

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Osumi, H., Shinozaki, E., Suenaga, M., Matsusaka, S., Konishi, T., Akiyoshi, T., Fujimoto, Y., Nagayama, S., Fukunaga, Y., Ueno, M., Mise, Y., Ishizawa, T., Inoue, Y., Takahashi, Y., Saiura, A., Uehara, H., Mun, M., Okumura, S., Mizunuma, N., Miki, Y., Yamaguchi, T.
RAS mutation is a prognostic biomarker in colorectal cancer patients with metastasectomy.
Int J Cancer, in press (2016)
Pal, S.K., Nguyen, C.T., Morita, K.I., Miki, Y., Kayamori, K., Yamaguchi, A., Sakamoto, K.
THBS1 is induced by TGFB1 in the cancer stroma and promotes invasion of oral squamous cell carcinoma.
J Oral Pathol Med, in press (2016)
Wang, J., Ding, Q., Fujimori, H., Motegi, A., Miki, Y., Masutani, M.
Loss of CtIP disturbs homologous recombination repair and sensitizes breast cancer cells to PARP inhibitors.
Oncotarget, 7, 7701-7714 (2016)
R. Khanom, C. T. Nguyen, K. Kayamori, X. Zhao, K. Morita, Y. Miki, K. Katsube, A. Yamaguchi and K. Sakamoto.
Keratin 17 Is induced in oral cancer and facilitates tumor growth.
PloS one, 11, e0161163 (2016)
S. Malik, H. Saito, M. Takaoka, Y. Miki and A. Nakanishi.
BRCA2 mediates centrosome cohesion via an interaction with cytoplasmic dynein.
Cell cycle, 15, 2145-2156 (2016)

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Nakamura, S., Takahashi, M., Tozaki, M., Nakayama, T., Nomizu, T., Miki, Y., Murakami, Y., Aoki, D., Iwase, T., Nishimura, S., Yamauchi, H., Ohsumi, S., Baba, S., Shimizu, T.
Prevalence and differentiation of hereditary breast and ovarian cancers in Japan.
Breast Cancer, 22, 462-468 (2015)

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Takaoka, M., Saito, H., Takenaka, K., Miki, Y., Nakanishi, A.
BRCA2 phosphorylated by PLK1 moves to the midbody to regulate cytokinesis mediated by nonmuscle myosin IIC.
Cancer Res, 74, 1518-1528 (2014)
Wada, Y., Matsuura, M., Sugawara, M., Ushijima, M., Miyata, S., Nagasaki, K., Noda, T., Miki, Y.
Development of detection method for novel fusion gene using GeneChip exon array.
J Clin Bioinforma, 4, 3 (2014)
Ishiba, T., Nagahara, M., Nakagawa, T., Sato, T., Ishikawa, T., Uetake, H., Sugihara, K., Miki, Y., Nakanishi, A.
Periostin suppression induces decorin secretion leading to reduced breast cancer cell motility and invasion.
Sci Rep, 4, 7069 (2014)
Kimura, H., Miki, Y., Nakanishi, A.
Centrosomes at M phase act as a scaffold for the accumulation of intracellular ubiquitinated proteins.
Cell Cycle, 13, 1928-1937 (2014)
Tan, T.Z., Miow, Q.H., Miki, Y., Noda, T., Mori, S., Huang, R.Y., Thiery, J.P.
Epithelial-mesenchymal transition spectrum quantification and its efficacy in deciphering survival and drug responses of cancer patients.
EMBO Mol Med, 6, 1279-1293 (2014)



Kawazu, M., Ueno, T., Kontani, K., Ogita, Y., Ando, M., Fukumura, K., Yamato, A., Soda, M., Takeuchi, K., Miki, Y., Yamaguchi, H., Yasuda, T., Naoe, T., Yamashita, Y., Katada, T., Choi, Y.L., Mano, H.
Transforming mutations of RAC guanosine triphosphatases in human cancers.
Proc Natl Acad Sci U S A, 110, 3029-3034 (2013)
Low, S.K., Takahashi, A., Ashikawa, K., Inazawa, J., Miki, Y., Kubo, M., Nakamura, Y., Katagiri, T.
Genome-wide association study of breast cancer in the Japanese population.
PLoS One, 8, e76463 (2013)
Nakamura, S., Takahashi, M., Tozaki, M., Nakayama, T., Nomizu, T., Miki, Y., Murakami, Y., Aoki, D., Iwase, T., Nishimura, S., Yamauchi, H., Ohsumi, S., Baba, S., Shimizu, T.
Prevalence and differentiation of hereditary breast and ovarian cancers in Japan.
Breast Cancer, in press (2013)
Wali, N., Hosokawa, K., Malik, S., Saito, H., Miyaguchi, K., Imajoh-Ohmi, S., Miki, Y., Nakanishi, A.
Centrosomal BRCA2 is a target protein of membrane type-1 matrix metalloproteinase (MT1-MMP).
Biochem Biophys Res Commun, 443, 1148-1154 (2013)



Iyevleva, A.G., Kuligina, E., Mitiushkina, N.V., Togo, A.V., Miki, Y., Imyanitov, E.N.
High level of miR-21, miR-10b, and miR-31 expression in bilateral vs. unilateral breast carcinomas.
Breast Cancer Res Treat, 131, 1049-1059 (2012)
Satoh, Y., Sugai, S., Uehara, H., Mun, M., Sakao, Y., Okumura, S., Nakagawa, K., Ishikawa, Y., Miki, Y., Miyata, S.
Clinical impact of intraoperative detection of carcinoembryonic antigen (CEA) in mRNA in pleural lavage specimens from non-small cell lung cancer.
Thorac Cardiovasc Surg, 60, 533-540 (2012)
Wang, L., Tsutsumi, S., Kawaguchi, T., Nagasaki, K., Tatsuno, K., Yamamoto, S., Sang, F., Sonoda, K., Sugawara, M., Saiura, A., Hirono, S., Yamaue, H., Miki, Y., Isomura, M., Totoki, Y., Nagae, G., Isagawa, T., Ueda, H., Murayama-Hosokawa, S., Shibata, T., Sakamoto, H., Kanai, Y., Kaneda, A., Noda, T., Aburatani, H.
Whole-exome sequencing of human pancreatic cancers and characterization of genomic instability caused by MLH1 haploinsufficiency and complete deficiency.
Genome Res, 22, 208-219 (2012)



Ito, Y., Nagasaki, K., Miki, Y., Iwase, T., Akiyama, F., Matsuura, M., Horii, R., Makita, M., Tokudome, N., Ushijima, M., Yoshimoto, M., Takahashi, S., Noda, T., Hatake, K.
Prospective randomized phase II study determines the clinical usefulness of genetic biomarkers for sensitivity to primary chemotherapy with paclitaxel in breast cancer.
Cancer Sci, 102, 130-136 (2011)
Wang, H.F., Takenaka, K., Nakanishi, A., Miki, Y.
BRCA2 and nucleophosmin coregulate centrosome amplification and form a complex with the Rho effector kinase ROCK2.
Cancer Res, 71, 68-77 (2011)



Niwa, T., Saito, H., Imajoh-ohmi, S., Kaminishi, M., Seto, Y., Miki, Y., Nakanishi, A.
BRCA2 interacts with the cytoskeletal linker protein plectin to form a complex controlling centrosome localization.
Cancer Sci, 100, 2115-2125 (2009)



Hirai, Y., Banno, K., Suzuki, M., Ichikawa, Y., Udagawa, Y., Sugano, K., Miki, Y.
Molecular epidemiological and mutational analysis of DNA mismatch repair (MMR) genes in endometrial cancer patients with HNPCC-associated familial predisposition to cancer.
Cancer Sci, 99, 1715-1719 (2008)
Izawa, N., Matsumoto, S., Manabe, J., Tanizawa, T., Hoshi, M., Shigemitsu, T., Machinami, R., Kanda, H., Takeuchi, K., Miki, Y., Arai, M., Shirahama, S., Kawaguchi, N.
A Japanese patient with Li-Fraumeni syndrome who had nine primary malignancies associated with a germline mutation of the p53 tumor-suppressor gene.
Int J Clin Oncol, 13, 78-82 (2008)
Shinagawa, H., Miki, Y., Yoshida, K.
BRCA1-mediated ubiquitination inhibits topoisomerase II alpha activity in response to oxidative stress.
Antioxid Redox Signal, 10, 939-949 (2008)
Sugano, K., Nakamura, S., Ando, J., Takayama, S., Kamata, H., Sekiguchi, I., Ubukata, M., Kodama, T., Arai, M., Kasumi, F., Hirai, Y., Ikeda, T., Jinno, H., Kitajima, M., Aoki, D., Hirasawa, A., Takeda, Y., Yazaki, K., Fukutomi, T., Kinoshita, T., Tsunematsu, R., Yoshida, T., Izumi, M., Umezawa, S., Yagata, H., Komatsu, H., Arimori, N., Matoba, N., Gondo, N., Yokoyama, S., Miki, Y.
Cross-sectional analysis of germline BRCA1 and BRCA2 mutations in Japanese patients suspected to have hereditary breast/ovarian cancer.
Cancer Sci, 99, 1967-1976 (2008)
Tanaka, S., Arii, S., Yasen, M., Mogushi, K., Su, N.T., Zhao, C., Imoto, I., Eishi, Y., Inazawa, J., Miki, Y., Tanaka, H.
Aurora kinase B is a predictive factor for the aggressive recurrence of hepatocellular carcinoma after curative hepatectomy.
Br J Surg, 95, 611-619 (2008)
Tomiyoshi, G., Nakanishi, A., Takenaka, K., Yoshida, K., Miki, Y.
Novel BRCA2-interacting protein BJ-HCC-20A inhibits the induction of apoptosis in response to DNA damage.
Cancer Sci, 99, 747-754 (2008)



Fujisawa, H., Isomura, M., Eguchi, S., Ushijima, M., Miyata, S., Miki, Y., Matsuura, M.
Identifying haplotype block structure using an ancestor-derived model.
J Hum Genet, 52, 738-746 (2007)
Han, X., Saito, H., Miki, Y., Nakanishi, A.
A CRM1-mediated nuclear export signal governs cytoplasmic localization of BRCA2 and is essential for centrosomal localization of BRCA2.
Oncogene, (2007)
Horii, R., Akiyama, F., Ito, Y., Matsuura, M., Miki, Y., Iwase, T.
Histological features of breast cancer, highly sensitive to chemotherapy.
Breast Cancer, 14, 393-400 (2007)
Liu, H., Lu, Z.G., Miki, Y., Yoshida, K.
Protein kinase C δ induces transcription of the TP53 tumor suppressor gene by controlling death-promoting factor Btf in the apoptotic response to DNA damage.
Mol Cell Biol, 27, 8480-8491 (2007)
Maekawa, T., Shinagawa, T., Sano, Y., Sakuma, T., Nomura, S., Nagasaki, K., Miki, Y., Saito-Ohara, F., Inazawa, J., Kohno, T., Yokota, J., Ishii, S.
Reduced levels of ATF-2 predispose mice to mammary tumors.
Mol Cell Biol, 27, 1730-1744 (2007)
Nakanishi, A., Han, X., Saito, H., Taguchi, K., Ohta, Y., Imajoh-Ohmi, S., Miki, Y.
Interference with BRCA2, which localizes to the centrosome during S and early M phase, leads to abnormal nuclear division.
Biochem Biophys Res Commun, 355, 34-40 (2007)
Nguyen, S.T., Hasegawa, S., Tsuda, H., Tomioka, H., Ushijima, M., Noda, M., Omura, K., Miki, Y.
Identification of a predictive gene expression signature of cervical lymph node metastasis in oral squamous cell carcinoma.
Cancer Sci, 98, 740-746 (2007)
Noda, H., Miyaji, Y., Nakanishi, A., Konishi, F., Miki, Y.
Frequent reduced expression of α-1B-adrenergic receptor caused by aberrant promoter methylation in gastric cancers.
Br J Cancer, 96, 383-390 (2007)
Oishi, Y., Nagasaki, K., Miyata, S., Matsuura, M., Nishimura, S., Akiyama, F., Iwai, T., Miki, Y.
Functional pathway characterized by gene expression analysis of supraclavicular lymph node metastasis-positive breast cancer.
J Hum Genet, 52, 271-279 (2007)
Taira, N., Nihira, K., Yamaguchi, T., Miki, Y., Yoshida, K.
DYRK2 is targeted to the nucleus and controls p53 via Ser46 phosphorylation in the apoptotic response to DNA damage.
Mol Cell, 25, 725-738 (2007)
Yamaguchi, T., Kimura, J., Miki, Y., Yoshida, K.
The deubiquitinating enzyme USP11 controls an IκB kinase alpha (IKKα)-p53 signaling pathway in response to tumor necrosis factor α (TNFα).
J Biol Chem, 282, 33943-33948 (2007)
Yamaguchi, T., Miki, Y., Yoshida, K.
Protein kinase C δ activates IκB-kinase α to induce the p53 tumor suppressor in response to oxidative stress.
Cell Signal, 19, 2088-2097 (2007)



Hayashi, T., Arai, M., Ueno, M., Kinoshita, H., Tada, Y., Koizumi, K., Miki, Y., Yamaguchi, T., Kato, Y., Utsunomiya, J., Muto, T., Sugihara, K.
Frequency of immunohistochemical loss of mismatch repair protein in double primary cancers of the colorectum and stomach in Japan.
Dis Colon Rectum, 49, S23-29 (2006)
Nagasaki, K., Miki, Y.
Gene expression profiling of breast cancer.
Breast Cancer, 13, 2-7 (2006)
Noda, H., Kato, Y., Yoshikawa, H., Arai, M., Togashi, K., Nagai, H., Konishi, F., Miki, Y.
Frequent involvement of ras-signalling pathways in both polypoid-type and flat-type early-stage colorectal cancers.
J Exp Clin Cancer Res, 25, 235-242 (2006)
Tokairin, Y., Kakinuma, S., Arai, M., Nishimura, M., Okamoto, M., Ito, E., Akashi, M., Miki, Y., Kawano, T., Iwai, T., Shimada, Y.
Accelerated growth of intestinal tumours after radiation exposure in Mlh1-knockout mice: evaluation of the late effect of radiation on a mouse model of HNPCC.
Int J Exp Pathol, 87, 89-99 (2006)
Yoshida, K., Liu, H., Miki, Y.
Protein kinase C δ regulates Ser46 phosphorylation of p53 tumor suppressor in the apoptotic response to DNA damage.
J Biol Chem, 281, 5734-5740 (2006)
Yoshida, K., Yamaguchi, T., Shinagawa, H., Taira, N., Nakayama, K.I., Miki, Y.
Protein kinase C δ activates topoisomerase IIα to induce apoptotic cell death in response to DNA damage.
Mol Cell Biol, 26, 3414-3431 (2006)