演題：Role of actin dynamics in cell fate plasticity of microenvironmental cells

演者：佐谷　秀行　博士（慶應義塾大学医学部　先端医科学研究所　遺伝子制御研究部門, Division of Gene Regulation, Institute for Advanced Medical Research (IAMR) Keio University School of Medicine）

抄録：Cancer-associated fibroblasts (CAFs) contribute to progression of cancer cells. CAF is characterized as an α-smooth muscle actin (α-SMA) positive cell and originated from not only resident fibroblast but also various cells such as adipocytes, epithelial cells and cancer cells. Among them, we have special interest in adipocytes because, in a subset of tumors, growth and metastasis occur as a result of the adipocyte-rich microenvironments. However, the molecular mechanism of adipocyte-CAF transition remains to be elucidated. We previously reported that inactivation of MKL1, a monomeric G-actin binding transcriptional coactivator, via actin cytoskeleton dynamics drives adipocyte differentiation of multipotent fibroblastic preadipocytes (Nat Commun 2014). We thus investigated the role of MKL1 in the adipocyte-CAF transition. Induction of MKL1 led to the conversion of mature adipocytes to CAF-like fibroblastic progenitors. Promoting adipocyte differentiation in CAFs may provide a novel therapeutic approach for modulating tumor microenvironment.

日時：２０１９年８月７日（水） １６：００〜１７：００

場所：吉田記念講堂

連絡先：中村 卓郎（内線５３９１）

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