^#Sato, S., ^#Kawamata, Y., ^#Takahashi, A., ^#Imai, Y.,Hanyu, A., Okuma, A., Takasugi, M., Yamakoshi, K., Sorimachi, H., Kanda, H., Ishikawa, Y., Sone, S., Nishioka, Y., ^*Ohtani, N. & *Hara, E.
Ablation of the p16^INK4a tumour suppressor reverses ageing phenotypes of klotho mice.
Nature Commun.., 6: 7035 doi: 10.1038/ncomms8035 (2015).

Demaria, M., Ohtani, N., Youssef, S.A., Rodier, F., Toussaint, W., Mitchell, J.R., Laberge, R.M., Vijg, J., van Steeg, H., Dolle, M.E.T., Hoeijmakers, J.H.J., de Bruin, A., Hara, E. & *Campisi, J.
An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA
Dev. Cell., 31: 722-733 (2014)

Johmura, Y., Shimada, M., Misaki, T., Naiki-Ito, A., Miyoshi, H., Motoyama, N., Ohtani, N., Hara, E., Nakamura, M., Morita, A., Takahashi, S. & *Nakanishi M.
Necessary and sufficient role for a mitosis skip in senescence induction.
Mol Cell., 55: 73-84 (2014)　

Imai, Y., Takahashi, A., Hanyu, A., Hori, S., Sato, S., Naka, K., Hirao, A., Ohtani, N. & *Hara, E.
Crosstalk between the Rb Pathway and AKT Signaling Forms a Quiescence-Senescence Switch.
Cell Rep., 7: 194-207 (2014)　

^#Yoshimoto, S., Loo, T.M., Atarashi, K., Kanda, H., Sato, S., Oyadomari, S., Iwakura, Y., Oshima, K., Morita, H., Hattori, M., Honda, K., Ishikawa, Y., *Hara, E. & ^#Ohtani, N.
Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome.
Nature., 499: 97-101(2013)　
(Selected for News & Views)
This work was featured in Science's 'Breakthrough of the Year 2013'

Takahashi, A., Imai, Y., Yamakoshi, K., Kuninaka, S., Ohtani, N., Yoshimoto, S., Hori, S., Tachibana, M., Anderton, E., Takeuchi, T., Shinkai, Y., Peters, G., Saya, H. & *Hara, E.
DNA damage signaling triggers degradation of histone methyltransferases through APC/C^Cdh1 in senescent cells.
Mol. Cell., 45: 123-131(2012)　

Yamamizu, K., Fujihara, M., Tachibana, M., Katayama, S., Takahashi, A., Hara, E., Imai, H., Shinkai, Y., & *Yamashita, J. K.
Protein kinase A determines timing of early differentiation through epigenetic regulation with G9a.
Cell Stem Cell., 10: 759-770(2012)　

^#Yamakoshi, K., ^#Takahashi, A., Hirota, F., Nakayama, R., Ishimaru, N., Kubo, Y., Mann, D.J., Ohmura, M., Hirao, A., Saya, H., Arase, S., Hayashi, Y., Nakao, K., Matsumoto, M., Ohtani, N.* & *Hara, E.
Real-time in vivo imaging of p16^INK4a reveals cross-talk with p53.
J. Cell Biol., 186: 393-407 (2009)

Inomata, K., Aoto, T., Binh, N.T., Okamoto, N., Tanimura, S., Wakayama, T., Iseki, S., Hara, E., Masunaga, T., Shimizu, H. & *Nishimura, E.K.
Genotoxic stress abrogates renewal of melanocyte stem cells by triggering their differentiation.
Cell, 137: 1088-1099 (2009)

*^#Ohtani, N., ^#Imamura, Y., Yamakoshi, K., Hirota, F., Nakayama, R., Kubo, Y., Ishimaru, N., Takahashi, A., Hirao, A., Shimizu, T., Mann, D.J., Saya, H., Hayashi, Y., Arase, S., Matsumoto, M., Nakao, K. & *Hara, E.
Visualizing the dynamics of p21Waf1/Cip1 cyclin-dependent kinase inhibitor expression in living animals
Proc. Natl. Acad. Sci. USA, 104: 15034-15039 (2007)

Takahashi, A., Ohtani, N., Yamakoshi, K., Iida, S., Tahara, H.,Nakayama, K., Nakayama, K.I., Ide, T., Saya, H. & *Hara, E.
Mitogenic signalling and the p16^INK4a-Rb pathway cooperate to enforce irreversible cellular senescence
Nature Cell Biol., 8: 1291-1297 (2006)
(Selected for News & Views)

*Laman, H., Funes, J., Ye, H., Henderson, S., Galinanes-Garcia, L., Hara, E., Knowles, P., McDonald, N. & Boshoff, C.
Transforming activity of Fbxo7 is mediated specifically through regulation of cyclinD/cdk6.
EMBO J., 24: 3104-3116 (2005)

Maehara, K., Yamakoshi, K., Ohtani, N., Kubo, Y., Takahashi, A., Arase, S., Jones, N. & *Hara, E.
Reduction of total E2F/DP activity induces senescence-like cell cycle arrest in cancer cells lacking functional pRB and p53.
J. Cell Biol., 167: 553-560 (2005)

Ohtani, N., Brennan, P., Gaubatz, S., Sanij, E., Hertzong, P., Wolvetang, E., Ghysdael, J., Rowe, M. & *Hara, E.
Epstein-Barr virus LMP1 blocks p16 INK4a-RB-pathway by promoting nuclear export of E2F4/5.
J. Cell Biol., 162: 173-183 (2003)
(Selected for Cover page)

Ohtani, N., Zebedee, Z., Huot, T.J.G., Stinson, J.A., Sugimoto, M., Ohashi, Y., Sharrrocks, A.D., Peters, G. & *Hara, E.
Opposing effects of Ets and Id proteins on p16^INK4a expression during cellular senescence.
Nature, 409: 1067-1070 (2001).

Sugimoto, M., Nakamura, T., Ohtani, N., Hampson, L., Hampson, I.N., Shimamoto, A., Furuichi, Y., Okumura, K., Niwa, S., Taya Y. & *Hara, E.
Regulation of CDK4 activity by a novel CDK4 binding protein, p34^SEI-1.
Genes & Dev., 13: 3027-3033 (1999).