原著論文
主要著書, 総説など

原著論文

  • Smith, E., Hegarat, N., Vesely, C., Roseboom, I., Streicher, H., Straatman, K., Flynn, H., Skehel, M., Hirota, T., Kuriyama, R., Hochegger, H. (2011) Differential control of Eg5 dependent centrosome separation by Plk1 and Cdk1. EMBO J. 30: 2233-2245.
  • Abe, S.,* Nagasaka, K.,* Hirayama, Y., Kozuka-Hata, H., Oyama, M., Aoyagi, Y., Obuse, C., Hirota, T. (2011) The initial phase of chromosome condensation requires Cdk1-mediated phosphorylation of the CAP-D3 subunit of condensin II.
    Genes & Dev. 25: 863-874. (equal contribution)
  • Itoh, G., Kanno, S., Uchida, K.S.K, Chiba, S., Sugino, S., Watanabe, K., Mizuno, K., Yasui, A., Hirota, T., Tanaka, K. (2011) CAMP (C13orf8, ZNF828) is a novel regulator of kinetochore-microtubule attachment. EMBO J. 30: 130-144.
  • Abe, Y., Okumura, E., Hosoya, T., Hirota, T.,* Kishimoto, T.* (2010) A single starfish Aurora performs dual functions of Auroras A and B in human cells J Cell Sci. 123: 3978-3988. (*joint corresponding author)
  • Nozawa, R., Nagao, K., Masuda, H., Iwasaki, O., Hirota, T., Nozaki, N., Kimura, H., Obuse, C. (2010) Human POGZ modulates HP1 dissociation from mitotic chromosome arms through Aurora B activation. Nat. Cell Biol.12: 719-727.
  • Kodama M, Otsubo C, Hirota T, Yokota J, Enari M, Taya Y. (2010) Requirement of ATM for Rapid p53 Phosphorylation at Ser46 without Ser/Thr-Gln Sequences. Mol. Cell Biol. 30: 1620-1633.
  • Ohishi, T., Hirota, T., Tsuruo, T., Seimiya, H. (2010) TRF1 mediates mitotic abnormalities induced by Aurora A overexpression. Cancer Res. 70: 2041-2052.
  • Uchida, K.S.K., Takagaki, K., Kumada, K,, Noda, T., Hirota, T. (2009) Kinetochore stretching inactivates the spindle assembly checkpoint.J Cell Biol. 184: 383-390.
  • Nakajima, M., Kumada, K., Hatakeyama, K., Noda, T., Peters, JM., Hirota, T. (2007) The complete removal of cohesin from chromosome arms depends on separase. J Cell Sci. 120: 4188-4196.
  • Lipp, JJ., Hirota, T., Peters, JM. (2007) Aurora B controls the association of condensin I but not condensin II with mitotic chromosomes. J Cell Sci. 120: 1245-1255.
  • Gerlich, D., Hirota, T., Koch, B., Peters, JM., Ellenberg, J. (2006) Condensin I stabilizes chromosomes mechanically through a dynamic interaction in living cells. Curr Biol. 16: 333-344.
  • Hirota, T., Lipp, JJ., Toh BH., Peters, JM. (2005) Histone H3 serine 10 phosphorylation by Aurora-B causes HP1 dissociation from heterochromatin. Nature. 438: 1176-1180.
  • Sasayama, T., Marumoto, T., Kunitoku,. N., Zhang, D., Tamaki, K., Kohmura, E., Saya, H., Hirota, T. (2005) Overexpression of Aurora-A targets cytoplasmic polyadenylation element binding protein and promotes mRNA polyadenylation of mitotic regulators. Genes Cells. 10: 627-638.
  • Kuninaka. S., Nomura, M., Hirota, T., Iida, S., Hara, T., Honda, S., Kunitoku, N., Sasayama, T., Arima, Y., Marumoto, T., Koja, K., Yonehara, S., Saya, H. (2005). The tumor suppressor WARTS activates the Omi/HtrA2-dependent pathway of cell death. Oncogene. 24: 5287-5298.
  • McGuinness, BE*., Hirota, T*., Kudo, NR., Peters, JM, Nasmyth, K (2005) Shugoshin prevents dissociation of cohesin from centromeres during mitosis in vertebrate cells. PLoS. Biol. 3: 433-449 (*joint first author)
  • Hirota, T., Gerlich, D., Koch, B., Ellenberg, J., Peters, JM. (2004) Distinct functions of condensin I and condensin II in mitotic chromosome assembly. J. Cell Sci. 15: 6435-6445.
  • Sumara, I., Gimenez-Abian, J.F., Gerlich, D., Hirota, T., Karft, C., Ellenberg, J., Peters, J.-M. (2004) Roles of Polo-like kinase 1 in the assembly of functional mitotic spindles Curr. Biol. 14: 1712-1722.
  • Zhang, D., Hirota, T., Marumoto, T., Shimizu, M., Kunitoku, N., Sasayama, T., Arima, Y., Suzuki, M., Takeya, M., Saya, H: (2004) Cre-loxP-controlled periodic Aurora-A overexpression induces mitotic abnormalities and hyperplasia in mammary glands of mouse models. Oncogene 18: 8720-8730.
  • Gimenez-Abian, J.F., Sumara, I., Hirota, T., Hauf, S., Gerlich, D., Torre, C., Ellenberg, J., Peters, J-.M. (2004) Regulation of sister chromatid cohesion between chromosome arms. Curr. Biol. 13: 2058-2064.
  • Nitta, M., Kobayashi, O., Honda, S., Hirota, T., Kuninaka, S., Marumoto, T., Ushio, Y., Saya, H. (2004) Spindle checkpoint function is required for mitotic catastrophe induced by DNA-damaging agents. Oncogene. 23: 6548-6558
  • Honda, S., Marumoto, T., Hirota, T., Nitta, M., Arima, Y., Ogawa, M., Saya, H. (2004) Activation of m-Calpain is required for chromosome alignment on the metaphase plate during mitosis. J. Biol. Chem. 279: 10615-10623.
  • Iida, S., Hirota, T., Morisaki, T., Marumoto, T., Hara, T., Kuninaka, S., Honda, S., Kosai, K., Kawasuji, Pallas, D.C., Saya, H. (2004) The tumor suppressor WARTS ensures genomic integrity by regulating both mitotic progression and G1 tetraploidy checkpoint function. Oncogene 23: 5266-5274.
  • Arima, Y., Hirota, T., Bronner, C., Mousli, M., Fujuwara, T., Niwa, S., Ishikawa, H., Saya, H. (2003) Downregulation of nuclear protein ICBP90 by p53/p21Cip1/WAF1-dependent DNA-damage checkpoint signals contributes to cell cycle arrest at G1/S transition. Genes Cells 9:131-142
  • Kunitoku, N., Sasayama, T., Marumoto, T., Zhang, D., Honda, S., Hatakeyama, K., Ushio, Y., Saya, H., Hirota, T. (2003) Aurora-A-dependent phosphorylation of CENP-A in prophase is essential for concentration of Aurora-B at inner centromeres and for kinetochore function. Dev. Cell 5: 853-864.
  • Hirota, T., Kunitoku, N., Sasayama, T., Marumoto, T., Zhang, D., Nitta, M., Hatakeyama, K., Saya, H. (2003) Aurora-A and an interacting activator, the LIM protein Ajuba, are required for mitotic commitment in human cells. Cell 144: 585-598.
  • Marumoto, T., Honda, S., Hara, T., Nitta, M., Hirota, T., Kohmura, E., Saya, H. (2003) Aurora-A kinase maintains the fidelity of early and late mitotic events in HeLa cells.
    J. Biol. Chem. 278: 51786-51795.
  • Yeong, F.M., Hombauer, H., Wendt, K., Hirota, T., Mudrak, I., Mechtler, K., Loregger, T. Marchler, A., Tanaka, K., Peters, J.-M., Ogris, E. (2003) Identification of a subunit of a novel kleisin-beta/SMC complex as a potential substrate of protein phosphatase 2A. Curr. Biol. 13: 2058-2064.
  • Marumoto, T., Hirota, T., Morisaki, T., Kunitoku, N., Zhang, D., Ichikawa, Y., Sasayama, T., Kuninaka, S., Mimori, T., Tamaki, T., Kimura, M., Okano, Y., Saya, H. (2002) Roles of Aurora-A kinase in mitotic entry and G2 checkpoint in mammalian cells.
    Genes Cells 7: 1173-1182.
  • Morisaki, T., Hirota, T., Iida, S., Marumoto, T., Hara, T., Nishiyama, Y., Kawasuji, M., Hiraoka, T., Mimori, T., Araki N., Izawa, I., Inagaki, M., Saya, H. (2002) WARTS tumor suppressor is phosphorylated by Cdc2/cyclin B at spindle poles during mitosis. FEBS Lett. 529: 319-324.
  • Hirota, T., Morisaki, T., Nishiyama, Y., Marumoto, T., Tada, K., Hara, T., Masuko, N., Inagaki, M., Hatakeyama, K., Saya, H. (2000) Zyxin, a regulator of actin filament assembly, targets the mitotic apparatus by interacting with h-warts/LATS1 tumor suppressor. J. Cell Biol. 149: 1073-1086.
  • Morinaga, N., Shitara, Y., Yanagita, Y., Koida, T., Kimura, M., Asao, T., Kimijima, I., Takenoshita, S., Hirota, T., Saya, H., Kuwano, H. (2000) Molecular analysis of the h-warts/LATS1 gene in human breast cancer. Int J Oncol. 17: 1125-1129.
  • Nishiyama, Y., Hirota, T., Morisaki, T., Hara, T., Marumoto, T., Iida, S., Makino, K., Yamamoto, H., Hiraoka, T., Kitamura, N., Saya, H. (1999) A human homolog of Drosophila warts tumor suppressor, h-warts, localized to mitotic apparatus and specifically phosphorylated during mitosis. FEBS Lett. 459: 159-165.
  • Koga, H., Matsui, S., Hirota, T., Takebayashi, S., Okumura, K., Saya, H. (1999) A human homolog of Drosophila lethal(3)malignant brain tumor (l(3)mbt) protein associates with condensed mitotic chromosomes. Oncogene. 18: 3799-3809.
  • Koga, H., Araki, N., Takeshima, H., Nishi, T., Hirota, T., Kimura, Y., Nakao, M., Saya, H. (1998) Impairment of cell adhesion by expression of the mutant neurofibromatosis type 2 (NF2) genes which lack exons in the ERM-homology domain. Oncogene. 17: 801-810.
  • Hirota, T., Nishimaki, T., Suzuki, T., Komukai, S., Kuwabara, S., Aizawa, K., Hatakeyama, K. (1998) Esophageal intramural metastasis from an adenocarcinoma of the gastric cardia: report of a case. Surg. Today. 28: 1160-1162.
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主要著書, 総説など

    　
  • Nagasaka, K., Gallego-Paez, L.M., Hirota, T. (2011) Mitosis and Meiosis: Molecular Control of Chromosome Separation. Review. Encyclopedia of Life Sciences, John Wiley & Sons, Ltd.
  • 広田　亨 (2010) 染色体動態を制御する動原体微小管のダイナミクス. 細胞工学 29 (9) 862-867
  • 広田　亨 (2010) 紡錘体形成チェックポイント. In 細胞周期フロンティア、佐方功幸ほか編（東京、共立出版）pp 94-101.
  • Tanaka, K., Hirota, T. (2009) Chromosome segregation machinery and cancer. Review. Cancer Sci. 100: 1158-1165.
  • 進藤軌久、広田　亨 (2009) ヒストンの化学修飾：新たな標的エピジェネティクスを目指して. 臨床血液 50(4) 282-288.
  • 中島真人、広田　亨 (2008) Aurora阻害薬. 分子細胞治療 4 (6) 480-488.
  • 広田　亨、進藤軌久 (2008) ヒストンのリン酸化によるクロマチン機能の制御. 実験医学 26: 1353-1358.
  • Hoshi, O., Hirota, T., Kimura, E., Komatsubara, N., Ushiki, T. (2007) Immunocytochemistry for analyzing chromosomes. Chromosome Nanoscience and Technology pp.79-87 CRC Press.
  • 大石智一、清宮啓之、広田　亨 (2007) Auroraキナーゼによる分裂期微小管の制御. 細胞 39 (11) 482-486
  • 広田　亨 (2007) 染色体の構築とその動態を制御する分裂期キナーゼAurora B. 実験医学 25 (5) 704-711
  • 榎本りま、広田　亨、園田英一朗、佐谷秀行 (2007) 細胞周期研究 In 細胞・培地活用ハンドブック：特徴、培養条件、入手法などの重要データがわかる、秋山徹ほか編（東京、羊土社）pp 20-27.
  • 広田　亨 (2006) ヒストンのリン酸化-動的エピジェネティクスをになう修飾. 実験医学 24 (8) 1110-1116
  • 広田　亨 (2006) オーロラキナーゼによる染色体の制御. 細胞工学 25(5) 506-510
  • 広田　亨 (2005) 染色体の形成と分配の分子機構. 分子細胞治療 4 (6) 480-488
  • 広田　亨 (2004) 分裂前期を制御するキナーゼ. 蛋白質・核酸・酵素 49 (8) 1183-1194
  • 広田　亨 (2004) 特集「Auroraキナーゼ：細胞分裂を制御する鍵分子」 監修 細胞工学
  • 篠山隆司、広田　亨、佐谷秀行 (2004) Aurora-Aの細胞分裂期における役割. 細胞工学 23 (3) 302-308
  • 佐谷秀行、広田　亨 (2004) 分裂期キナーゼによる細胞分裂進行の制御. 実験医学 22 (9) 1237-41
  • 広田　亨、佐谷秀行 (2000) Ｇ2/Ｍ期チェックポイント破綻による染色体異常　細胞工学 19 (10)
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