Program Members

上野 貴之

Program Director
Breast Surgery

丸山 玲緒

Associate Program Director
Cancer Biology / Informatics

高橋 暁子

Project Leader
Cancer Biology

斉藤 典子

Scientist
Cancer Biology / Molecular Biology

立和名 博昭

Scientist
Epigenetics

亜森 マハムット

Scientist
Oncology

鈴鹿 淳

Scientist
Oncology

宮田 憲一

Scientist
Cancer Biology / Bioinformatics

早川 智久

Scientist
Molecular Biology

尾辻 和尊

Clinical Research Fellow
Breast Surgery

松永 有紀

Clinical Research Fellow
Breast Surgery

粂川 昂平

Clinical Research Fellow
Oncology / Bioinformatics

家里 明日美

Clinical Research Fellow
Oncology / Breast Surgery

中筋 奈未

Technical Assistant
Bioinformatics

増田 薫

Technical Assistant
Veterinary Pathology

雪野 佳奈

Technical Assistant
Molecular Biology

Marinela Perpelescu

Technical Assistant
Epigenetics

岩見 真吾

Visiting Scientist
Mathematical Oncology

川上 英良

Visiting Scientist
AI Medicine

中岡 慎治

Visiting Scientist
Mathematical Oncology

高橋 洋子

Visiting Scientist
Breast Surgery

山下 奈真

Research Scholar
Breast Surgery

久野 真弘

Trainee
Medical Oncologyy

佐野 麻美

Administrative Assistant

Advisory Board

大野 真司

Adviser
Breast Surgery

Kornelia Polyak, M.D., Ph.D.

Adviser
Cancer Biology

Ian E. Krop, M.D., Ph.D.

Adviser
Medical Oncology

Publications

1. Iesato A, Fushimi A, Tahara R, Terada M, Iwase M, Kawamura C, Yamashita N. A novel system to provide information via online YouTube videos and an evaluation of current online information about hereditary breast cancer. Breast Cancer. in press.
2. Inoue F, Sone K, Kumegawa K, Toyohara Y, Tanimoto S, Natsumi T, Takahashi Y, Kusakabe M, Kukita A, Honjoh H, Nishijima A, Taguchi A, Miyamoto Y, Tanikawa M, Iriyama T, Uchino M, Wada-Hiraike O, Oda K, Suzuki H, Maruyama R, Osuga Y. Activation of interferon signaling and induction of apoptosis by the inhibition of protein arginine methyltransferase 6 via histone modification in endometrial cancer cells. Int J Oncol. in press.
3. Qian J, Zhou X, Tanaka K, Takahashi A. Alteration in the chromatin landscape during the DNA damage response: Continuous rotation of the gear driving cellular senescence and aging. DNA Repair. 2023 Nov;131:103572.
4. Miyata K, Zhou X, Nishio M, Hanyu A, Chiba M, Kawasaki H, Osako T, Takeuchi K, Ohno S, Ueno T, Maruyama R, Takahashi A. Chromatin conformational changes at human satellite II contribute to the senescence phenotype in the tumor microenvironment. Proc Natl Acad Sci U S A. 2023 Aug 8;120(32):e2305046120.
5. Kitajima H, Maruyama R, Niinuma T, Yamamoto E, Takasawa A, Takasawa K, Ishiguro K, Tsuyada A, Suzuki R, Sudo G, Kubo T, Mitsuhashi K, Idogawa M, Tange S, Toyota M, Yoshido A, Kumegawa K, Kai M, Yanagihara K, Tokino T, Osanai M, Nakase H, Suzuki H. TM4SF1-AS1 inhibits apoptosis by promoting stress granule formation in cancer cells. Cell Death Dis. 2023 Jul 13;14(7):424.
6. Yi JM, Kang TH, Han YK, Park HY, Yang JH, Bae JH, Suh JS, Kim TJ, Kim JG, Cui YH, Suzuki H, Kumegawa K, Kim SJ, Zhao Y, Park IJ, Hong SM, Chung JY, Lee SJ. Human Neuralized is a novel tumour suppressor targeting Wnt/β-catenin signalling in colon cancer. EMBO Rep. 2023 Aug 3;24(8):e56335.
7. Kumegawa K, Yang L, Miyata K, Maruyama R. FOXD1 is associated with poor outcome and maintains tumor-promoting enhancer-gene programs in basal-like breast cancer. Front Oncol. 2023 May 10;13:1156111.
8. Saeki S, Kumegawa K, Takahashi Y, Yang L, Osako T, Yasen M, Otsuji K, Miyata K, Yamakawa K, Suzuka J, Sakimoto Y, Ozaki Y, Takano T, Sano T, Noda T, Ohno S, Yao R, Ueno T, Maruyama R. Transcriptomic intratumor heterogeneity of breast cancer patient-derived organoids may reflect the unique biological features of the tumor of origin. Breast Cancer Res. 2023 Feb 21;25(1):21.
9. Otsuji K, Tanabe M, Morizono A, Harada M, Sato A, Niwa T, Nishioka K, Seto Y. Exploring Predictive Risk Factors of Infusion Reactions with First Pertuzumab Administration in HER2-positive Breast Cancer Patients: A Single Institution Experience. JMA J. 2023 Jan 16;6(1):63-72.
10. Misawa T, Hitomi K, Miyata K, Tanaka Y, Fujii R, Chiba M, Loo TM, Hanyu A, Kawasaki H, Kato H, Maezawa Y, Yokote K, Nakamura AJ, Ueda K, Yaegashi N, Takahashi A. Identification of Novel Senescent Markers in Small Extracellular Vesicles. Int J Mol Sci. 2023 Jan 26;24(3):2421.
11. Kumegawa K, Saeki S, Takahashi Y, Yang L, Osako T, Nakadai T, Amino S, Maeda T, Takahata C, Mori S, Noda T, Ohno S, Ueno T, Maruyama R. Chromatin profile- based identification of a novel ER-positive breast cancer subgroup with reduced ER-responsive element accessibility. Br J Cancer. 2023 Mar;128(7):1208-1222.
12. Nakadai T, Shimada M, Ito K, Cevher MA, Chu CS, Kumegawa K, Maruyama R, Malik S, Roeder RG. Two target gene activation pathways for orphan ERR nuclear receptors. Cell Res. 2023 Feb;33(2):165-183. doi: 10.1038/s41422-022-00774-z. Epub 2023 Jan 16. PMID: 36646760; PMCID: PMC9892517.
13. Sugawara S, Okada R, Loo TM, Tanaka H, Miyata K, Chiba M, Kawasaki H, Katoh K, Kaji S, Maezawa Y, Yokote K, Nakayama M, Oshima M, Nagao K, Obuse C, Nagayama S, Takubo K, Nakanishi A, Kanemaki MT, Hara E, Takahashi A. RNaseH2A downregulation drives inflammatory gene expression via genomic DNA fragmentation in senescent and cancer cells. Commun Biol. 2022 Dec 28;5(1):1420.
14. Nakadai T, Yang L, Kumegawa K, Maruyama R. Estrogen receptorα K303R mutation reorganizes its binding to forkhead box protein A1 regions and induces chromatin opening. Mol Biol Rep. 2023 Feb;50(2):1209-1220.
15. Igarashi N, Miyata K, Loo TM, Chiba M, Hanyu A, Nishio M, Kawasaki H, Zheng H, Toyokuni S, Kon S, Moriyama K, Fujita Y, Takahashi A. Hepatocyte growth factor derived from senescent cells attenuates cell competition-induced apical elimination of oncogenic cells. Nat Commun. 2022 Jul 18;13(1):4157.
16. Kumegawa K, Takahashi Y, Saeki S, Yang L, Nakadai T, Osako T, Mori S, Noda T, Ohno S, Ueno T, Maruyama R. GRHL2 motif is associated with intratumor heterogeneity of cis-regulatory elements in luminal breast cancer. NPJ Breast Cancer. 2022 Jun 8;8(1):70.
17. Miyata K, Takahashi A. Pericentromeric repetitive ncRNA regulates chromatin interaction and inflammatory gene expression. Nucleus. 2022 Dec;13(1):74-78.
18. Miyata K, Imai Y, Hori S, Nishio M, Loo TM, Okada R, Yang L, Nakadai T, Maruyama R, Fujii R, Ueda K, Jiang L, Zheng H, Toyokuni S, Sakata T, Shirahige K, Kojima R, Nakayama M, Oshima M, Nagayama S, Seimiya H, Hirota T, Saya H, Hara E, Takahashi A. Pericentromeric noncoding RNA changes DNA binding of CTCF and inflammatory gene expression in senescence and cancer. Proc Natl Acad Sci U S A. 2021 Aug 31;118(35):e2025647118.
19. Otsuji K, Sasaki T, Tanabe M, Seto Y. Quantitative assessment of HER2 gene amplification of breast cancer using droplet digital PCR. Pathol Int. 2021 Aug;71(8):538-547.