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TORU HIROTA Laboratory
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論文発表

原著論文　主要著書, 総説など

原著論文

  • Hara, M., Ariyoshi, M., Sano, T., Nozawa, R.S., Shinkai, S., Onami, S., Jansen, I., Hirota, T. and Fukagawa, T. (2023) Centromere/kinetochore is assembled through CENP-C oligomerization. Mol Cell. 83: 2188-2205. doi: 10.1016/j.molcel.2023.05.023.
  • Mahana, Y., Ariyoshi, M., Nozawa, R-S., Shibata, S., Nagao, K., Obuse, C., and Shirakawa, M. (2023) Structural evidence for protein–protein interaction between the non-canonical methyl-CpG-binding domain of SETDB proteins and C11orf46 Structure. S0969-2126(23)00443-4. doi: 10.1016/j.str.2023.12.001.
  • Kamakura, N., Takahashi, M. and Jo, M. (2023) The toxicity of dysregulated Plk1 activity revealed by its suppressor mutations Genes Cells. doi: 10.1111/gtc.13032
  • Kakui, Y., Barrington, C., Kusano, Y., Thadani, R., Fallesen, T., Hirota, T., and Uhlmann, F. (2022) Chromosome arm length, and a species-specific determinant, define chromosome arm width. Cell Rep. 41: 111753.
  • Shindo, N., Kumada, K., Iemura, K., Yasuda, J., Fujimori, H., Mochizuki, M., Tamai, K., Tanaka, K., and Hirota, T. (2022) Autocleavage of separase suppresses its premature activation by promoting binding to cyclin B1. Cell Rep. 41: 111723.
  • Kitajima, S., Tani, T., Springer, B. F., Campisi, M., Osaki, T., Haratani, K., Chen, M., Knelson, E. H., Mahadevan, N. R., Ritter, J., Yoshida, R., Köhler, J., Ogino, A., Nozawa, R. S., Sundararaman, S. K., Thai, T. C., Homme, M., Piel, B., Kivlehan, S., Obua, B. N., Purcell, C., Yajima, M., Barbie, T. U., Lizotte, P. H., Jänne, P. A., Paweletz, C. P., Gokhale, P. C., Barbie, D. A. (2022) MPS1 inhibition primes immunogenicity of KRAS-LKB1 mutant lung cancer. Cancer Cell. 40: 1128-1144.
  • Naughton C., Huidobro C., Catacchio C.R., Buckle A., Grimes G.R., Nozawa R.S., Purgato S., Rocchi M., Gilbert N. (2022) Human centromere repositioning activates transcription and opens chromatin fibre structure. Nat Commun. 24;13(1):5609.
  • *Negoto, T., *Jo, M., Nakayama, I., Morioka, M., Takeuchi, K., Kawachi, H., and Hirota T. (2022) Profiling chromosome-level variations in gastric malignancies. Cancer Science. 113: 3864-3876. doi: 10.1111/cas.15544 (*co-first author)
  • Kitagawa, Y., Akiyoshi, T., Yamamoto, N., Mukai, T., Hiyoshi, Y., Yamaguchi, T., Nagasaki, T., Fukunaga, Y., Hirota, T., Noda, T., Kawachi, H. (2022) Tumor-infiltrating PD-1+ immune cell density is associated with response to neoadjuvant chemoradiotherapy in rectal cancer. Clin Colorectal Cancer. 21(1): e1-e11 DOI: 10.1016/j.clcc.2022.01.004.
  • Miyata, K., Imai, Y., Hori, S., Nishio, M., Loo, T.M., Okada, R., Yang, L., Nakadai, T., Maruyama, R., Fujii, R., Ueda, K., Jiang, Li., Zheng, H., Toyokuni, S., Sakata, T., Shirahige, K., Kojima, R., Nakayama, M., Oshima, M., Nagayama, S., Seimiya, H., Hirota, T., Saya, H., Hara, E. and Takahashi, A. (2021) Pericentromeric noncoding RNA changes DNA binding of CTCF and inflammatory gene expression in senescence and cancer. Proc Natl Acad Sci USA. 118(35)： e2025647118.
  • Matsui, S., and Nozawa, R.S. (2021) RNA impacts formation of biomolecular condensates in the nucleus. Biomed. Res. 42: 153-160.
  • Rii, J., Sakamoto, S., Sugiura, M., Kanesaka, M., Fujimoto, A., Yamada, Y., Maimaiti, M., Ando, K., Wakai, K., Xu, M., Imamura, Y., Shindo, N., Hirota, T., Kaneda, A., Kanai, Y., Ikehara, Y., Anzai, N., Ichikawa, T. (2021)Functional analysis of LAT3 in prostate cancer: its downstream target and relationship with androgen receptor. Cancer Sci. 112: 3871-3883.
  • Uchida, KSK., Jo, M., Nagasaka, K., Takahashi, M., Shindo, N., Shibata, K., Tanaka, K., Masumoto, H., Fukagawa, T., and Hirota, T. (2021) Kinetochore stretching-mediated rapid silencing of the spindle-assembly checkpoint required for failsafe chromosome segregation. Curr. Biol. 31: 1581-1591.
  • Shindo, N., Otsuki, M., Uchida, KSK., and Hirota, T. (2021) Prolonged mitosis causes separase deregulation and chromosome nondisjunction. Cell Rep. 34: 108652.
  • Yoshida, R., Hagio, T., Kaneyasu, T., Gotoh, O., Osako, T., Tanaka, N., Amino, S., Yaguchi, N., Nakashima, E., Kitagawa, D., Ueno, T., Ohno, S., Nakajima, T., Nakamura, S., Miki, Y., Hirota, T., Takahashi, S., Matsuura, M., Noda, T., Mori, S. (2021) Pathogenicity assessment of variants for breast cancer susceptibility genes based on BRCAness of tumor sample. Cancer Sci. 112: 1310-1319.
  • Boteva, L., Nozawa, R. S., Naughton, C., Samejima, K., Earnshaw, W. C., Gilbert, N. (2020) Common fragile sites are characterized by faulty condensin loading after replication stress. Cell Rep. 32 (12) 108177.
  • Kinjo, K., Nagasaki, K., Muroya, K., Suzuki, E., Ishiwata, K., Nakabayashi, K., Hattori, A., Nagao, K., Nozawa, R. S., Obuse, C., Miyado, K., Ogata, T., Fukami, M., Miyado, M. (2020) Rare variant of the epigenetic regulator SMCHD1 in a patient with pituitary hormone deficiency. Sci. Rep. 10 (1): 10985.
  • Fujimura, A., Hayashi, Y., Kato, K., Kogure, Y., Kameyama, M., Shimamoto, H., Daitoku, H., Fukamizu, A., Hirota, T., Kimura, K. (2020) Identification of a novel nucleolar protein complex required for mitotic chromosome segregation through centromeric accumulation of Aurora B. Nucleic Acids Res. 48（12）： 6583-6596.
  • Watson, N.A., Cartwright, T.N., Lawless, C., Camara-Donoso, M., Sen, O., Sako, K., Hirota, T., Kimura, H., Higgins, J.M.G. (2020) Kinase iinhibition profiles as a tool to identify kinases for specific phosphorylation sites. Nat Commun. 11: 1684.
  • Nishibuchi, G., Machida, S., Nakagawa, R., Yoshimura, Y., Hiragami-Hamada, K., Abe, Y., Kurumizaka, H., Tagami, H., Nakayama, J. I. (2019) Mitotic phosphorylation of HP1α regulates its cell cycle-dependent chromatin binding. J. Biochem. 165 (5): 433-446.
  • Takahashi, M., Hirota, T. (2019) Folding the genome into mitotic chromosomes. Curr Opin Cell Biol. 60: 19-26.
  • Nishimura, K., Johmura, Y., Deguchi, K., Jiang, Z., Uchida, KSK., Suzuki, N., Shimada, M., Chiba, Y., Hirota, T., Yoshimura, SH., Kono, K,. Nakanish, M (2019) Cdk1-mediated DIAPH1 phosphorylation maintains metaphase cortical tension and inactivates the spindle assembly checkpoint at anaphase. Nat Comm. 10: 981-993.
  • Nakayama, I., Shinozaki, E., Sakata, S., Yamamoto, N., Fujisaki, J., Muramatsu, Y., Hirota, T., Takeuchi, K., Takahashi, S., Yamaguchi, K., Noda, T. (2019) Enrichment of CLDN18-ARHGAP fusion gene in gastric cancers in young adults. Cancer Sci. 110: 1352–1363.
  • Takahashi, M., Hirota, T. (2018) Dynamics of sister chromatids through the cell cycle: Together and apart. Spotlight. J Cell Biol. 217 (6): 1887-1889
  • Hayashi, Y., Fujimura, A., Kato, K., Udagawa, R., Hirota, T., Kimura, K. (2018) Nucleolar integrity during interphase supports faithful Cdk1 activation and mitotic entry. Sci Adv. 4 (6): eaap7777
  • Konishi, M., Shindo, N., Komiya, M., Tanaka, K., Itoh, T., Hirota, T. (2018) Quantitative analyses of the metaphase-to-anaphase transition reveal differential kinetic regulation for securin and cyclin B1. Biomed Res. 39: 75-85. doi: 10.2220/biomedres.39.75.
  • Takahashi, M., Wakai, T., Hirota, T. (2016) Condensin I-mediated mitotic chromosome assembly requires association with chromokinesin KIF4A. Genes Dev. 30(17): 1931-1936.
  • Tanaka, K., Hirota, T. (2016) Chromosomal instability: a common feature and a therapeutic target of cancer. Biochim Biophys Acta. 1866: 64-75.
  • Abe, Y., Hirota, T. (2016) System-level deficiencies in Aurora B control in cancers. Cell Cycle. 15: 2091-2092.
  • Nagasaka, K., Hossain, MJ., Roberti, MJ., Ellenberg, J., Hirota, T. (2016) Sister chromatid resolution is an intrinsic part of chromosome organization in prophase. Nat Cell Biol. 18: 692-699.
  • Abe, Y., Sako, K., Takagaki, K., Hirayama, Y., Uchida, KS., Herman, J., DeLuca, JG., Hirota, T. (2016) HP1-assisted Aurora B kinase activity prevents chromosome segregation errors. Dev. Cell. 36: 487-497.
  • Takahashi, M., Tanaka, K., Wakai, T., Hirota, T. (2016) Phosphoproteomic analysis of human mitotic chromosomes identified a chromokinesin KIF4A. Biomed Res. 37: 161-165.
  • Nagasaka, K. and Hirota, T. (2015) Clarifying the role of condensin in shaping chromosomes. News and Views. Nat Cell Biol. 17: 711-713
  • Minamino, M., Ishibashi, M., Nakato, R., Akiyama, K., Tanaka, H., Kato, Y., Negishi, L., Hirota, T., Sutani, T., Bando, M., Shirahige, K. (2015) Esco1 acetylates cohesin via a mechanism different from that of Esco2. Curr. Biol. 25: 1694-706.
  • Gallego-Paez, LM., Tanaka, H., Bando, M., Takahashi, M., Nozaki, N., Nakato,R., Shirahige, K., and Hirota, T. (2014) Smc5/6-mediated replication progression contributes to chromosome assembly in human cells. Mol. Biol. Cell. 25 (2): 302-317.
  • Ando, K., Ozaki, T., Hirota, T., Nakagawara, A. (2013) NFBD1/MDC1 is phosphorylated by Plk1 and controls G2/M transition through the regulation of Topoisomerase II alpha-mediated decatenation checkpoint. PLoS One. 8 (12): e82744.
  • Earnshaw, W. C., Allshire, R. C., Black, B. E., Bloom, K., Brinkley, B. R., Brown, W., Cheeseman, I. M., Choo, K. H. A., Copenhaver, G. P., DeLuca, J. G., Desai, A., Diekmann, S., Erhardt, S., Fitzgerald-Hayes, M., Foltz, D., Fukagawa, T., Gassmann, R., Gerlich, D. W., Glover, D. M., Gorbsky, G. J., Harrison, S. C., Heun, P., Hirota, T., Jansen, L. E. T., Karpen, G., Kops, G. J. P., Lampson, M. A., Lens, S. M., Losada, A., Luger, K., Maiato, H., Maddox, P. S., Margolis, R. L., Masumoto, H., McAinsh, A. D., Mellone, B. G., Meraldi, P., Musacchio, A., Oegema, K., O'Neill, R. J., Salmon, E. D., Scott, K., Straight, A. F., Stukenberg, P. T., Sullivan, B. A., Sullivan, K. F., Sunkel, C. E., Swedlow, J. R., Walczak, C. E., Warburton, P. E., Westermann, S., Willard, H. F., Wordeman, L., Yanagida, M., Yen, T. J., Yoda, K., Cleveland, D. W.(2013) Esperanto for Histones: CENP-A, not CenH3, is the centromeric histone H3 variant. Commentary. Chromosome Res. 21(2): 101-106
  • Itoh, G., Sugino, S., Mizuguchi, M., Kanno, S., Amin, MA., Iemura, K., Ikeda, M., Yasui, A., Hirota, T., Tanaka, K. (2013) The nucleoporin Nup188 is required for chromosome alignment in mitosis. Cancer Sci. 104(7): 871-879
  • Deardorff MA., Bando, M., Nakato, R., Watrin, E., Itoh, T., Minamino, M.,Saitoh,K., Komata, M., Katou, Y., Clark, D., Cole, KE., De Baere, E., Decroos, C., Di Donato, N., Ernst, S., Francey, LJ., Gyftodimou, Y., Hirashima, K., Hullings, M., Ishikawa, Y., Jaulin, C., Kaur, M., Kiyono, T., Lombardi, PM., Magnaghi-Jaulin, L., Mortier, GR., Nozaki, N., Petersen, MB., Seimiya, H., Siu, VM., Suzuki, Y., Takagaki, K., Wilde, JJ., Willems, PJ, Prigent, C., Gillessen-Kaesbach, G., Christianson, DW., Kaiser, FJ., Jackson, LG., Hirota, T., Krantz ID., Shirahige K. (2012) HDAC8 mutations in Cornelia de Lange syndrome affect the cohesin acetylation cycle. Nature Nature 489: 313-317.
  • Shindo, N., Kumada, K., Hirota, T. (2012) Separase-sensor reveals dual roles for separase coordinating cohesin cleavage and cdk1 inhibition. Dev. Cell 23: 112-123.
  • Smith, E., Hegarat, N., Vesely, C., Roseboom, I., Streicher, H., Straatman, K., Flynn, H., Skehel, M., Hirota, T., Kuriyama, R., Hochegger, H. (2011) Differential control of Eg5 dependent centrosome separation by Plk1 and Cdk1. EMBO J. 30: 2233-2245.
  • Abe, S.,* Nagasaka, K.,* Hirayama, Y., Kozuka-Hata, H., Oyama, M., Aoyagi, Y., Obuse, C., Hirota, T. (2011) The initial phase of chromosome condensation requires Cdk1-mediated phosphorylation of the CAP-D3 subunit of condensin II.
    Genes & Dev. 25: 863-874. (equal contribution)
  • Itoh, G., Kanno, S., Uchida, K.S.K, Chiba, S., Sugino, S., Watanabe, K., Mizuno, K., Yasui, A., Hirota, T., Tanaka, K. (2011) CAMP (C13orf8, ZNF828) is a novel regulator of kinetochore-microtubule attachment. EMBO J. 30: 130-144.
  • Abe, Y., Okumura, E., Hosoya, T., Hirota, T.,* Kishimoto, T.* (2010) A single starfish Aurora performs dual functions of Auroras A and B in human cells J Cell Sci. 123: 3978-3988. (*joint corresponding author)
  • Nozawa, R., Nagao, K., Masuda, H., Iwasaki, O., Hirota, T., Nozaki, N., Kimura, H., Obuse, C. (2010) Human POGZ modulates HP1 dissociation from mitotic chromosome arms through Aurora B activation. Nat. Cell Biol.12: 719-727.
  • Kodama M, Otsubo C, Hirota T, Yokota J, Enari M, Taya Y. (2010) Requirement of ATM for Rapid p53 Phosphorylation at Ser46 without Ser/Thr-Gln Sequences. Mol. Cell Biol. 30: 1620-1633.
  • Ohishi, T., Hirota, T., Tsuruo, T., Seimiya, H. (2010) TRF1 mediates mitotic abnormalities induced by Aurora A overexpression. Cancer Res. 70: 2041-2052.
  • Uchida, K.S.K., Takagaki, K., Kumada, K,, Noda, T., Hirota, T. (2009) Kinetochore stretching inactivates the spindle assembly checkpoint.J Cell Biol. 184: 383-390.
  • Nakajima, M., Kumada, K., Hatakeyama, K., Noda, T., Peters, JM., Hirota, T. (2007) The complete removal of cohesin from chromosome arms depends on separase. J Cell Sci. 120: 4188-4196.
  • Lipp, JJ., Hirota, T., Peters, JM. (2007) Aurora B controls the association of condensin I but not condensin II with mitotic chromosomes. J Cell Sci. 120: 1245-1255.
  • Gerlich, D., Hirota, T., Koch, B., Peters, JM., Ellenberg, J. (2006) Condensin I stabilizes chromosomes mechanically through a dynamic interaction in living cells. Curr Biol. 16: 333-344.
  • Hirota, T., Lipp, JJ., Toh BH., Peters, JM. (2005) Histone H3 serine 10 phosphorylation by Aurora-B causes HP1 dissociation from heterochromatin. Nature. 438: 1176-1180.
  • Sasayama, T., Marumoto, T., Kunitoku,. N., Zhang, D., Tamaki, K., Kohmura, E., Saya, H., Hirota, T. (2005) Overexpression of Aurora-A targets cytoplasmic polyadenylation element binding protein and promotes mRNA polyadenylation of mitotic regulators. Genes Cells. 10: 627-638.
  • Kuninaka. S., Nomura, M., Hirota, T., Iida, S., Hara, T., Honda, S., Kunitoku, N., Sasayama, T., Arima, Y., Marumoto, T., Koja, K., Yonehara, S., Saya, H. (2005). The tumor suppressor WARTS activates the Omi/HtrA2-dependent pathway of cell death. Oncogene. 24: 5287-5298.
  • McGuinness, BE*., Hirota, T*., Kudo, NR., Peters, JM, Nasmyth, K (2005) Shugoshin prevents dissociation of cohesin from centromeres during mitosis in vertebrate cells. PLoS. Biol. 3: 433-449 (*joint first author)
  • Hirota, T., Gerlich, D., Koch, B., Ellenberg, J., Peters, JM. (2004) Distinct functions of condensin I and condensin II in mitotic chromosome assembly. J. Cell Sci. 15: 6435-6445.
  • Sumara, I., Gimenez-Abian, J.F., Gerlich, D., Hirota, T., Karft, C., Ellenberg, J., Peters, J.-M. (2004) Roles of Polo-like kinase 1 in the assembly of functional mitotic spindles Curr. Biol. 14: 1712-1722.
  • Zhang, D., Hirota, T., Marumoto, T., Shimizu, M., Kunitoku, N., Sasayama, T., Arima, Y., Suzuki, M., Takeya, M., Saya, H: (2004) Cre-loxP-controlled periodic Aurora-A overexpression induces mitotic abnormalities and hyperplasia in mammary glands of mouse models. Oncogene 18: 8720-8730.
  • Gimenez-Abian, J.F., Sumara, I., Hirota, T., Hauf, S., Gerlich, D., Torre, C., Ellenberg, J., Peters, J-.M. (2004) Regulation of sister chromatid cohesion between chromosome arms. Curr. Biol. 13: 2058-2064.
  • Nitta, M., Kobayashi, O., Honda, S., Hirota, T., Kuninaka, S., Marumoto, T., Ushio, Y., Saya, H. (2004) Spindle checkpoint function is required for mitotic catastrophe induced by DNA-damaging agents. Oncogene. 23: 6548-6558
  • Honda, S., Marumoto, T., Hirota, T., Nitta, M., Arima, Y., Ogawa, M., Saya, H. (2004) Activation of m-Calpain is required for chromosome alignment on the metaphase plate during mitosis. J. Biol. Chem. 279: 10615-10623.
  • Iida, S., Hirota, T., Morisaki, T., Marumoto, T., Hara, T., Kuninaka, S., Honda, S., Kosai, K., Kawasuji, Pallas, D.C., Saya, H. (2004) The tumor suppressor WARTS ensures genomic integrity by regulating both mitotic progression and G1 tetraploidy checkpoint function. Oncogene 23: 5266-5274.
  • Arima, Y., Hirota, T., Bronner, C., Mousli, M., Fujuwara, T., Niwa, S., Ishikawa, H., Saya, H. (2003) Downregulation of nuclear protein ICBP90 by p53/p21Cip1/WAF1-dependent DNA-damage checkpoint signals contributes to cell cycle arrest at G1/S transition. Genes Cells 9:131-142
  • Kunitoku, N., Sasayama, T., Marumoto, T., Zhang, D., Honda, S., Hatakeyama, K., Ushio, Y., Saya, H., Hirota, T. (2003) Aurora-A-dependent phosphorylation of CENP-A in prophase is essential for concentration of Aurora-B at inner centromeres and for kinetochore function. Dev. Cell 5: 853-864.
  • Hirota, T., Kunitoku, N., Sasayama, T., Marumoto, T., Zhang, D., Nitta, M., Hatakeyama, K., Saya, H. (2003) Aurora-A and an interacting activator, the LIM protein Ajuba, are required for mitotic commitment in human cells. Cell 144: 585-598.
  • Marumoto, T., Honda, S., Hara, T., Nitta, M., Hirota, T., Kohmura, E., Saya, H. (2003) Aurora-A kinase maintains the fidelity of early and late mitotic events in HeLa cells.
    J. Biol. Chem. 278: 51786-51795.
  • Yeong, F.M., Hombauer, H., Wendt, K., Hirota, T., Mudrak, I., Mechtler, K., Loregger, T. Marchler, A., Tanaka, K., Peters, J.-M., Ogris, E. (2003) Identification of a subunit of a novel kleisin-beta/SMC complex as a potential substrate of protein phosphatase 2A. Curr. Biol. 13: 2058-2064.
  • Marumoto, T., Hirota, T., Morisaki, T., Kunitoku, N., Zhang, D., Ichikawa, Y., Sasayama, T., Kuninaka, S., Mimori, T., Tamaki, T., Kimura, M., Okano, Y., Saya, H. (2002) Roles of Aurora-A kinase in mitotic entry and G2 checkpoint in mammalian cells.
    Genes Cells 7: 1173-1182.
  • Morisaki, T., Hirota, T., Iida, S., Marumoto, T., Hara, T., Nishiyama, Y., Kawasuji, M., Hiraoka, T., Mimori, T., Araki N., Izawa, I., Inagaki, M., Saya, H. (2002) WARTS tumor suppressor is phosphorylated by Cdc2/cyclin B at spindle poles during mitosis. FEBS Lett. 529: 319-324.
  • Hirota, T., Morisaki, T., Nishiyama, Y., Marumoto, T., Tada, K., Hara, T., Masuko, N., Inagaki, M., Hatakeyama, K., Saya, H. (2000) Zyxin, a regulator of actin filament assembly, targets the mitotic apparatus by interacting with h-warts/LATS1 tumor suppressor. J. Cell Biol. 149: 1073-1086.
  • Morinaga, N., Shitara, Y., Yanagita, Y., Koida, T., Kimura, M., Asao, T., Kimijima, I., Takenoshita, S., Hirota, T., Saya, H., Kuwano, H. (2000) Molecular analysis of the h-warts/LATS1 gene in human breast cancer. Int J Oncol. 17: 1125-1129.
  • Nishiyama, Y., Hirota, T., Morisaki, T., Hara, T., Marumoto, T., Iida, S., Makino, K., Yamamoto, H., Hiraoka, T., Kitamura, N., Saya, H. (1999) A human homolog of Drosophila warts tumor suppressor, h-warts, localized to mitotic apparatus and specifically phosphorylated during mitosis. FEBS Lett. 459: 159-165.
  • Koga, H., Matsui, S., Hirota, T., Takebayashi, S., Okumura, K., Saya, H. (1999) A human homolog of Drosophila lethal(3)malignant brain tumor (l(3)mbt) protein associates with condensed mitotic chromosomes. Oncogene. 18: 3799-3809.
  • Koga, H., Araki, N., Takeshima, H., Nishi, T., Hirota, T., Kimura, Y., Nakao, M., Saya, H. (1998) Impairment of cell adhesion by expression of the mutant neurofibromatosis type 2 (NF2) genes which lack exons in the ERM-homology domain. Oncogene. 17: 801-810.
  • Hirota, T., Nishimaki, T., Suzuki, T., Komukai, S., Kuwabara, S., Aizawa, K., Hatakeyama, K. (1998) Esophageal intramural metastasis from an adenocarcinoma of the gastric cardia: report of a case. Surg. Today. 28: 1160-1162.
ページの先頭へ

主要著書, 総説など

    　 　
  • Shimozaki, K., Nakayama, I., Hirota, T., Yamaguchi, K. (2023) Current strategy to treat immunogenic gastrointestinal cancers: perspectives for a new era. Cells. In-press.
  • Jo, M., Kusano, Y., and Hirota, T. (2021) Unraveling pathologies underlying chromosomal instability in cancers. Review. Cancer Sci. 112: 2975-2983.
  • 野澤竜介、小布施力史 (2021) 相分離メカニズムと疾患 : ヘテロクロマチンの形成メカニズム. 実験医学 39 (10): 143-148.
  • 野澤竜介 (2020) 第II部 相分離メガネのかけ方 : 核マトリックスと核メッシュ. 相分離生物学の全貌 (白木賢太郎編集) 東京化学同人 p. 104-107
  • Nakayama, I., Hirota, T., Shinozaki, E. (2020) BRAF mutation in colorectal cancers: from prognostic marker to targetable mutation. Review. Cancers 12: 3236.
  • Nozawa R.S., Yamamoto T., Takahashi M., Tachiwana H., Maruyama R., Hirota T., and Saitoh N. (2020) Nuclear microenvironment in cancer: control through liquid-liquid phase separation. Cancer Sci. 111(9): 3155-3163.
  • Yoshizawa T., Nozawa R.S., Jia Z.T., Saio T., Mori E. (2020) Biological Phase Separation: Cell Biology Meets Biophysics.Biophys. Rev.12(2): 519-539.
  • 野澤竜介 (2020) 超解像顕微鏡とクラスター解析機能を用いたRNAポリメラーゼI の局在解析.Nikon Application Note.
  • 野澤竜介、原　幸大、丁　大橋 (2020) 液-液相分離を介したクロマチン構造と機能の制御.生物工学会誌 98(5): 228-254.
  • Takahashi, M., Hirota, T. (2019) Folding the genome into mitotic chromosomes.Curr. Opin. Cell Biol. 60: 19-26.
  • 内田和彦、広田　亨 (2018) 染色体分配：マルチステップに進む姉妹染色分体の分離.実験医学 36 (17): 135-141.
  • 高橋元子、広田　亨 (2017) M期における染色体構築のメカニズム.生化学 89 (4): 515-524.
  • 小西　惇、松高　愛、広田　亨 (2015) 染色体不安定性の成因. 細胞 47 (5): 215-218.
  • 高橋元子、進藤軌久、広田　亨 (2014)ライブ・セル・イメージング解析を用いた細胞分裂研究法：バイオセンサーによる酵素活性の時空間的解析.実験講座.Surgery Frontier, 21 (2): 205-209.
  • 進藤軌久、広田　亨 (2013)第1部 エピジェネティクスの分子機構：ヒストン修飾とその制御③ヒストンのリン酸化.イラストで徹底理解するエピジェネティクスキーワード事典：分子機構から疾患・解析技術まで (牛島俊和, 真貝洋一編集), 東京, 羊土社 p.61-66.
  • 進藤軌久、広田　亨 (2013)第2部 生命現象とエピジェネティクス：その他の染色体制御.イラストで徹底理解するエピジェネティクスキーワード事典：分子機構から疾患・解析技術まで (牛島俊和, 真貝洋一編集), 東京, 羊土社 p.116-122.
  • 高橋元子、広田　亨 (2013)What's New in SURGERY FRONTIER(第79回) 細胞周期の最新知見①リン酸化による染色体凝縮の制御 コンデンシンに焦点をあてて.Surgery Frontier, 20 (4): 420-424.
  • 進藤軌久 (2013)What's New in SURGERY FRONTIER(第79回) 細胞周期の最新知見②癌と染色体分配機構.Surgery Frontier, 20 (4): 426-429.
  • 進藤軌久、広田　亨 (2013)細胞分裂の仕組みに迫る：染色体分離のキー酵素separaseの活性の可視化と作用機序の解明.バイオサイエンスとインダストリー, 71 (3): 229-233.
  • 阿部優介 (2013)ヒトと医学のステージへ拡大する細胞周期2013　がん治療と生命現象の解明をめざして：(第1章)高等動物における細胞周期制御　Greatwallによるリン酸化バランス調節に基づくM期開始制御. 実験医学 31 (2): 175-181.
  • 進藤軌久 (2012) バイオセンサーにより明らかにされた染色体分離におけるセパラーゼの異なる2つの役割.ライフサイエンス新着論文レビューFIRST AUTHOR'S
  • Nagasaka, K., Gallego-Paez, L.M., Hirota, T. (2011) Mitosis and Meiosis: Molecular Control of Chromosome Separation. Review. Encyclopedia of Life Sciences, John Wiley & Sons, Ltd.
  • 広田　亨 (2010) 染色体動態を制御する動原体微小管のダイナミクス. 細胞工学 29 (9) 862-867.
  • 広田　亨 (2010) 紡錘体形成チェックポイント. In 細胞周期フロンティア、佐方功幸ほか編（東京、共立出版）pp 94-101.
  • Tanaka, K., Hirota, T. (2009) Chromosome segregation machinery and cancer. Review. Cancer Sci. 100: 1158-1165.
  • 進藤軌久、広田　亨 (2009) ヒストンの化学修飾：新たな標的エピジェネティクスを目指して. 臨床血液 50(4) 282-288.
  • 中島真人、広田　亨 (2008) Aurora阻害薬. 分子細胞治療 4 (6) 480-488.
  • 広田　亨、進藤軌久 (2008) ヒストンのリン酸化によるクロマチン機能の制御. 実験医学 26: 1353-1358.
  • Hoshi, O., Hirota, T., Kimura, E., Komatsubara, N., Ushiki, T. (2007) Immunocytochemistry for analyzing chromosomes. Chromosome Nanoscience and Technology pp.79-87. CRC Press.
  • 大石智一、清宮啓之、広田　亨 (2007) Auroraキナーゼによる分裂期微小管の制御. 細胞 39 (11) 482-486.
  • 広田　亨 (2007) 染色体の構築とその動態を制御する分裂期キナーゼAurora B. 実験医学 25 (5) 704-711.
  • 榎本りま、広田　亨、園田英一朗、佐谷秀行 (2007) 細胞周期研究 In 細胞・培地活用ハンドブック：特徴、培養条件、入手法などの重要データがわかる、秋山徹ほか編（東京、羊土社）pp 20-27.
  • 広田　亨 (2006) ヒストンのリン酸化-動的エピジェネティクスをになう修飾. 実験医学 24 (8) 1110-1116.
  • 広田　亨 (2006) オーロラキナーゼによる染色体の制御. 細胞工学 25(5) 506-510.
  • 広田　亨 (2005) 染色体の形成と分配の分子機構. 分子細胞治療 4 (6) 480-488.
  • 広田　亨 (2004) 分裂前期を制御するキナーゼ. 蛋白質・核酸・酵素 49 (8) 1183-1194.
  • 広田　亨 (2004) 特集「Auroraキナーゼ：細胞分裂を制御する鍵分子」 監修 細胞工学
  • 篠山隆司、広田　亨、佐谷秀行 (2004) Aurora-Aの細胞分裂期における役割. 細胞工学 23 (3) 302-308.
  • 佐谷秀行、広田　亨 (2004) 分裂期キナーゼによる細胞分裂進行の制御. 実験医学 22 (9) 1237-41.
  • 広田　亨、佐谷秀行 (2000) Ｇ2/Ｍ期チェックポイント破綻による染色体異常　細胞工学 19 (10)