The Cancer Genome Dynamics Project was established in April 2022. While actively recruiting graduate students and research fellows, we pursue a central question: how genomic stability is maintained in our bodies and what triggers its breakdown.
In multicellular organisms, tissues are formed and sustained through continuous cell division. Each division requires faithful duplication of genomic DNA, which carries genetic information. The molecular mechanisms of DNA replication are highly sophisticated, ensuring both efficiency and accuracy. Nevertheless, genome duplication is not error-free. Mutations inevitably arise and accumulate with age, contributing to the development of cancer and other diseases.
Our research focuses on elucidating the molecular mechanisms of DNA replication and genome maintenance, with the ultimate goal of understanding how mutations are generated.