Akiko Takahashi
Cellular Senescence
Cellular senescence is the state of irreversible cell cycle arrest provoked by a variety of potentially oncogenic stimuli. Cellular senescence appears to be acting as a barrier to cancer, preventing damaged cells from undergoing aberrant proliferation. On the other hand, it has been proven that senescent cells are accumulating during aging process throughout living body and secrete many inflammatory protei ns into the surrounding extracellular fluid. This phenomenon is called senescence-associated secretory phenotype (SASP), suggesting that SASP factors promote some age-associated diseases such as chronic inflammation and cancer. We have tried to reveal the molecular mechanisms why SASP factor gene expressions are upregulated in senescent cells. In our laboratory, we are aiming to understand the molecular mechanisms of cellular senescence and SASP. Our research will provide valuable new insights into the development of age-associated pathology including cancer and provide us new possibilities of its control.
New Info
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Our recent work is published in Science Advances！
2024.10.28
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Our recent work is published in Nature Reviews Molecular Cell Biology！
2024.10.9
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Our recent work is published in Nature Cell Biology！
2024.9.4
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Our recent work is published in Cancer Science！
2024.6.1
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Our recent work is published in ACS Nano！
2024.1.4
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Our recent work is published in Int. J. Mol. Sci.！
2023.11.16
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Our recent work is published in DNA Repair！
2023.9.29
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Our recent work is published in PNAS！
2023.8.1
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Our recent work is published in Int. J. Mol. Sci.！
2023.1.28
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Our recent work is published in Communications Biology！
2022.12.28
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Our recent work is published in Nature Communications！
2022.7.19
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Our recent work is published in Cells！
2022.6.17
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Our recent work is published in PNAS！
2021.8.23
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Our recent work is published in Nature Communications！
2020.4.22
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Our recent work is published in Cancer Science！
2020.2.7
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Our recent work is published in Nature Communications！
2018.3.29
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Our recent work is published in Nature Communications！
2017.6.7
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Our recent work is published in Nature Communications！
2017.5.16
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Our home page is uploaded！
2017.5.1
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We start new project for Cellular Senescence at the Cancer Institute！
2017.4.1
Publications
- DPP4-targeted activatable fluorescent probes visualize senescent cells.
- YBX1 regulates satellite II RNA loading into small extracellular vesicles and promotes the senescent phenotype.
- Chromatin conformational changes at human satellite II contribute to the senescence phenotype in the tumor microenvironment.
- Identification of novel senescent markers in small extracellular vesicles.
- RNaseH2A downregulation drives inflammatory gene expression via genomic DNA fragmentation in senescent and cancer cells.
- Hepatocyte growth factor derived from senescent cells attenuates cell competition-induced apical elimination of oncogenic cells.
- Pericentromeric noncoding RNA changes DNA binding of CTCF and inflammatory gene expression in senescence and cancer.
- Downregulation of cytoplasmic DNases is implicated in cytoplasmic DNA accumulation and SASP in senescent cells. Nature Communications
- Small extracellular vesicles secreted from senescent cells promote cancer cell proliferation through EphA2. Nature Communications
- Exosomes maintain cellular homeostasis by excreting harmful DNA from cells. Nature Communications
- Ablation of the p16INK4a tumour suppressor reverses ageing phenotypes of klotho mice. Nature Communications
- Crosstalk between the Rb Pathway and AKT Signaling Forms a Quiescence-Senescence Switch. Cell Rep.
Others
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Membership
・International Cell Senescence Association
・International Society for Extracellular Vesicles
・Japanese Cancer Association
・The Molecular Biology Society of Japan
・Japanese Society of Anti-Aging Medicine -
Area of Research
・Cellular senescence
・Cell cycle
・Tumor biology
・Molecular biology
Links
contents
Contact Us
- Cellular senescence, The Cancer Institute, Japanese Foundation for Cancer Research 3-8-31, Ariake, Koto-ku, Tokyo 135-8550 Japan
- +81-3-3520-0111 (ext.5353)
- akiko.takahashi@jfcr.or.jp