英文原著

  • Yasuda, T., Koiwa, M., Yonemura, A., Miyake, K., Kariya, R., Kubota, S., Yokomizo-Nakano, T., Yasuda-Yoshihara, N., Uchihara, T., Itoyama, R., Bu, L., Fu, L., Arima, K., Izumi, D., Iwagami, S., Eto, K., Iwatsuki, M., Baba, Y., Yoshida, N., Ohguchi, H., Okada, S., Matsuzaki, K., Sashida, G., Takahashi, A., Tan, B., Baba, H., Ishimoto, T.
    Inflammation-driven senescence-associated secretory phenotype in cancer-associated fibroblasts enhances peritoneal dissemination.
    Cell Reports, 34(8), 108779 (2021).
  • Obara, R., Kamiya, M., Tanaka, Y., Kojima, R., Kawaguchi, T., Sugawara, M., Takahashi, A., Noda, T. and Urano, Y.
    GGT-activatable fluorescence probe for durable tumor imaging.
    Angewandte Chemie Int. Edi., 60(4), 2125-2129 (2021).
  • Hitomi, K., Okada, R., Loo, T.M., Miyata, K. and Takahashi, A.
    DNA damage regulates senescence-associated extracellular vesicle release via the ceramide pathway to prevent excessive inflammatory responses.
    International Journal of Molecular Sciences, 21(10), 3720 (2020).
  • Wakita, M., Takahashi, A., Sano, O., Loo, T.M., Imai, Y., Narukawa, M., Iwata, H., Matsudaira, T., Kawamoto, K., Ohtani, N., Yoshimori, T. and Hara, E.
    A BET family protein degrader provokes senolysis by targeting NHEJ and autophagy in senescent cells.
    Nature Communications, 11, 1935 doi: 10.1038/s41467-020-15719-6 (2020).
  • *Takahashi, A., *Loo, T.M., *Okada, R., Kamachi, F., Watanabe, Y., Wakita, M., Watanabe, S., Kawamoto, S., Miyata, K., Barber, G.N., Ohtani, N. and Hara, E.
    Downregulation of cytoplasmic DNases is implicated in cytoplasmic DNA accumulation and SASP in senescent cells.
    Nature Communications, 9, 1249 doi:10.1038/s41467-018-03555-8 (2018).
    (*Takahashi, Loo and Okada contributed equally to this paper.)
  • Takasugi, M., Okada, R., Takahashi, A., Chen, T., Watanabe, S. and Hara, E.
    Small extracellular vesicles secreted from senescent cells promote cancer cell proliferation through EphA2.
    Nature Communications, 8, 15729 doi:10.1038/ncomms15728 (2017).
  • *Takahashi, A., Okada, R., Nagao, K., Kawamata, Y., Hanyu, A., Yoshimoto, S., Takasugi, M., Watanabe, S., Kanemaki, M.T., Obuse, C. and *Hara, E.
    Exosomes maintain cellular homeostasis by excreting harmful DNA from cells.
    Nature Communications, 8, 15287 doi: 10.1038/NCOMMS15287 (2017).
    (*Takahashi and Hara are co-corresponding to this paper.)
  • *Sato, S., *Kawamata, Y., *Takahashi, A., *Imai, Y., Hanyu, A., Okuma, A., Takasugi, M., Yamakoshi, K, Sorimachi, H., Sone, S., Nishioka, Y, Ohtani, N. and Hara, E.
    Ablation of the p16INK4a tumour suppressor reverses ageing phenotypes of klotho mice.
    Nature Communications, 6: 7035 doi: 10.1038/ncomms8035 (2015).
    (*Sato, Kawamata, Takahashi and Imai contributed equally to this paper.)
  • Imai, Y., Takahashi, A., Hanyu, A., Hori, S., Sato, S., Naka, K., Hirao, A., Ohtani, N. and Hara, E.
    Crosstalk between the Rb Pathway and AKT Signaling Forms a Quiescence-Senescence Switch.
    Cell Rep., 7, 194-207 (2014) 
  • Takahashi, A., Imai, Y., Yamakoshi, K., Kuninaka, S., Ohtani, N., Yoshimoto, S., Hori, S., Tachibana, M., Anderton, E., Takeuchi, T., Shinkai, Y., Peters, G., Saya, H. & Hara, E.
    DNA Damage Signaling Triggers Degradation of Histone Methyltransferases through APC/C(Cdh1) in Senescent Cells.
    Mol Cell. 45, 123-131 (2012)
  • Fukuyo, Y., Takahashi, A., Hara, E., Horikoshi, N., Pandita, T.K. & Nakajima, T.
    E2FBP1 antagonizes the p16(INK4A)-Rb tumor suppressor machinery for growth suppression and cellular senescence by regulating promyelocytic leukemia protein stability.
    Int J Oral Sci. 3, 200-208 (2011)
  • Takeuchi, S., Takahashi, A., Motoi, N., Tajima, T., Yamakoshi, K., Yoshimoto, S., Hirao, A., Yanagi, S., Fukami, K., Ishikawa, Y., Sone, S. & Hara, E.
    Intrinsic cooperation between p16INK4a and p21Waf1/Cip1 in the onset of cellular senescence and tumor suppression in vivo.
    Cancer Res. 70, 9381-9390 (2010)
  • *Yamakoshi, K., *Takahashi, A., Hirose, F., Nakayama, R., Ishimaru, N., Kubo, Y., Mann, D.J., Ohmura, M., Hirao, A., Saya, H., Arase, S., Hayashi, Y., Nakao, K., Matsumoto, M., Ohtani, N. & Hara, E.
    Real-time in vivo imaging of p16Ink4a reveals crosstalk with p53
    J. Cell Biol., 186, 393-407 (2009)
    (*Yamakoshi and Takahashi contributed equally to this paper.)
  • Ohtani, N., Imamura, Y., Yamakoshi, K., Hirota, F., Nakayama, R., Kubo, Y., Ishimaru, N., Takahashi, A., Hirao, A., Shimizu, T., Mann, D.J., Saya, H., Hayashi, Y., Arase, S., Matsumoto, M., Nakao, K. & Hara, E.
    Visualizing the dynamics of p21Waf1/Cip1 cyclin-dependent kinase inhibitor expression in living mice
    Proc. Natl. Acad. Sci. USA, 104, 15034-15039 (2007)
  • Takahashi, A., Ohtani, N., Yamakoshi, K., Iida, S., Tahara, H.,Nakayama, K., Nakayama, K.I., Ide, T., Saya, H. & Hara, E.
    Mitogenic signalling and the p16INK4a/Rb pathway co-operate to enforce irreversible cellular senescence
    Nature Cell Biol., 8, 1291-1297 (2006)
  • Maehara, K., Yamakoshi, K., Ohtani, N., Kubo, Y., Takahashi, A., Arase, S., Jones, N. & Hara, E.
    Reduction of total E2F/DP activity induces senescence-like cell cycle arrest in cancer cells lacking functional pRB and p53.
    J. Cell Biol., 167, 553-560 (2005)