Publications
Cellular senescence
- Yamauchi, S., Sugiura, Y., Yamaguchi, J., Zhou, X., Takenaka, S., Odawara, T., Fukaya, S., Fujisawa, T., Naguro, I., Uchiyama, Y., Takahashi, A. and Ichijo, H.
Mitochondrial fatty acid oxidation drives senescence.
Science Advances, 10(43), eado5887 (2024).
- Yanagawa, K., Kuma, A., Hamasaki, M., Kita, S., Yamamuro, T., Nishino, K., Nakamura, S., Omori, H., Kaminishi, T., Oikawa, S., Kato, Y., Edahiro, R., Kawagoe, R., Taniguchi, T., Tanaka, Y., Shima, T., Tabata, K., Iwatani, M., Bekku, N., Hanayama, R., Okada, Y., Akimoto, T., Kosako, H., Takahashi, A., Shimomura, I., Sakata, Y. and Yoshimori, T.
Rubicon-WIPI axis regulates exosome biogenesis during aging.
Nature Cell Biology,26(9), 1558-1570 (2024).
- Tanaka, H., Sugawara, S., Tanaka, Y., Loo, T.M., Tachibana, R., Abe, A., Kamiya, M., Urano, Y. and Takahashi, A.
DPP4-targeted activatable fluorescent probes visualize senescent cells.
Cancer Science, 115 (8), 2762-2773 (2024).
- Okawa, H., Tanaka, Y. & Takahashi, A.
The network of extracellular vesicles surrounding senescent cells.
Archives of Biochemistry and Biophysics, 754, 109953 (2024).
- Kimura, N., Tanaka, Y., Yamanishi, Y., Takahashi, A. and Sakuma, S.
Nanoparticles based on natural-lipids reveal extent of impacts of designed physical characteristics on biological functions.
ACS Nano, 18(2), 1432-1448, (2024).
- Chiba, M., Miyata, K., Okawa, H., Tanaka, Y., Ueda, K., Seimiya, H. and Takahashi, A.
YBX1 regulates satellite II RNA loading into small extracellular vesicles and promotes the senescent phenotype.
International Journal of Molecular Sciences, 24(22), 16399 (2023).
- Qian, J., Zhou, X., Tanaka, K. & Takahashi, A.
Alteration in the chromatin landscape during the DNA damage response: Continuous rotation of the gear driving cellular senescence and aging.
DNA Repair, 131, 103572 (2023).
- Miyata, K., Zhou, X., Nishio, M., Hanyu, A., Chiba, M., Kawasaki, H., Osako, T., Ohno, S., Ueno, T., Maruyama, R, and Takahashi, A.
Chromatin conformational changes at human satellite II contribute to the senescence phenotype in the tumor microenvironment.
Proc. Natl. Acad. Sci. U.S.A., 120 (32) e2305046120 (2023).
- Misawa, T., Hitomi, K., Miyata, K., Tanaka, Y., Fujii, R., Chiba, M., Loo, T.M., Hanyu, A., Kawasaki, H., Kato, H., Maezawa, Y., Yokote, K., Nakamura, A.J., Ueda, K., Yaegashi, N. and Takahashi, A.
Identification of novel senescent markers in small extracellular vesicles.
International Journal of Molecular Sciences, 24 (3), 2421 (2023).
- Sugawara, S., Okada, R., Loo, T.M., Tanaka, H., Miyata, K., Chiba, M., Kawasaki, H., Katoh, K., Kaji, S., Maezawa, Y., Yokote, K., Nakayama, M., Oshima, M., Nagao, K., Obuse, C., Nagayama, S., Nakanishi, A., Kanemaki, MT., Hara, E. and Takahashi, A.
RNaseH2A downregulation drives inflammatory gene expression via genomic DNA fragmentation in senescent and cancer cells.
Communications Biology, 5, 1420 (2022).
- Igarashi, N., Miyata, K., Loo, T.M., Chiba, T., Hanyu, A., Nishio, M., Kawasaki, H., Zheng, H., Toyokuni, S., Kon, S., Moriyama, K., Fujita, Y. and Takahashi, A.
Hepatocyte growth factor derived from senescent cells attenuates cell competition-induced apical elimination of oncogenic cells.
Nature Communications, 13, 4157, (2022).
- Ebata, H., Loo, T.M. & Takahashi, A.
Telomere Maintenance and the cGAS-STING Pathway in Cancer.
Cells, 11(12), 1958 (2022).
- Miyata, K. and Takahashi, A.
Pericentromeric repetitive ncRNA regulates chromatin interaction and inflammatory gene expression.
Nucleus, 13(1), 74-78 (2022).
- Okumura, S., Konishi, Y., Narukawa, M., Sugiura, Y, Yoshimoto, S., Arai, Y., Sato, S., Yoshida, Y., Tsuji, S., Uemura, K., Wakita, M., Matsudaira, T., Matsumoto, T., Kawamoto, S., Takahashi, A., Itatani, Y., Miki, H., Takamatsu, M, Obama, K., Takeuchi, K., Suematsu, M., Ohtani, N., Fukunaga, Y., Ueno, M., Sakai, Y., Nagayama, S. and Hara, E.
Identification of gut bacteria abundant in CRC patients that promote tumourigenesis via butyrate secretion.
Nature Communications, 12(1), 5674 (2021).
- Miyata, K., Imai, Y., Hori, S., Nishio, M., Loo, T.M., Okada, R., Yang, L., Nakadai, T., Maruyama, R., Fujii, R., Ueda, K., Jiang, Li., Zheng, H., Toyokuni, S., Sakata, T., Shirahige, K., Kojima, R., Nakayama, M., Oshima, M., Nagayama, S., Seimiya, H., Hirota, T., Saya, H., Hara, E. and Takahashi, A.
Pericentromeric noncoding RNA changes DNA binding of CTCF and inflammatory gene expression in senescence and cancer.
Proc. Natl. Acad. Sci. U.S.A., 118(35), e2025647118 (2021).
- Tasaki, Y., Suzuki, M., Katsushima, K., Shinjo, K., Iijima, K., Murofushi, Y., Naiki-Ito, A., Hayashi, K., Qiu, C., Takahashi, A., Tanaka, Y., Kawaguchi, T., Sugawara, M., Kataoka, T., Naito, M., Miyata, K., Kataoka, K., Noda, T., Gao, W., Kataoka, H., Takahashi, S., Kimura, K., Kondo, Y.
Cancer-specific targeting of taurine upregulated gene 1 enhances the effects of chemotherapy in pancreatic cancer.
Cancer Research, 81(7), 1654-1666 (2021).
- Yasuda, T., Koiwa, M., Yonemura, A., Miyake, K., Kariya, R., Kubota, S., Yokomizo-Nakano, T., Yasuda-Yoshihara, N., Uchihara, T., Itoyama, R., Bu, L., Fu, L., Arima, K., Izumi, D., Iwagami, S., Eto, K., Iwatsuki, M., Baba, Y., Yoshida, N., Ohguchi, H., Okada, S., Matsuzaki, K., Sashida, G., Takahashi, A., Tan, B., Baba, H., Ishimoto, T.
Inflammation-driven senescence-associated secretory phenotype in cancer-associated fibroblasts enhances peritoneal dissemination.
Cell Reports, 34(8), 108779 (2021).
- Obara, R., Kamiya, M., Tanaka, Y., Kojima, R., Kawaguchi, T., Sugawara, M., Takahashi, A., Noda, T. and Urano, Y.
GGT-activatable fluorescence probe for durable tumor imaging.
Angewandte Chemie Int. Edi., 60(4), 2125-2129 (2021).
- Hitomi, K., Okada, R., Loo, T.M., Miyata, K. and Takahashi, A.
DNA damage regulates senescence-associated extracellular vesicle release via the ceramide pathway to prevent excessive inflammatory responses.
International Journal of Molecular Sciences, 21(10), 3720 (2020).
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Wakita, M., Takahashi, A., Sano, O., Loo, T.M., Imai, Y., Narukawa, M., Iwata, H., Matsudaira, T., Kawamoto, K., Ohtani, N., Yoshimori, T. and Hara, E.
A BET family protein degrader provokes senolysis by targeting NHEJ and autophagy in senescent cells.
Nature Communications, 11, 1935 doi: 10.1038/s41467-020-15719-6 (2020).
- Loo, T.M., Miyata, K., Tanaka, Y., & Takahashi, A.
Cellular senescence and senescence‐associated secretory phenotype via the cGAS‐STING signaling pathway in cancer.
Cancer Science. 111, 304-311 (2020).
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*Takahashi, A., *Loo, T.M., *Okada, R., Kamachi, F., Watanabe, Y., Wakita, M., Watanabe, S., Kawamoto, S., Miyata, K., Barber, G.N., Ohtani, N. and Hara, E.
Downregulation of cytoplasmic DNases is implicated in cytoplasmic DNA accumulation and SASP in senescent cells.
Nature Communications, 9, 1249 doi:10.1038/s41467-018-03555-8 (2018).
(*Takahashi, Loo and Okada contributed equally to this paper.)
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Takasugi, M., Okada, R., Takahashi, A., Chen, T., Watanabe, S. and Hara, E.
Small extracellular vesicles secreted from senescent cells promote cancer cell proliferation through EphA2.
Nature Communications, 8, 15729 doi:10.1038/ncomms15728 (2017).
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*Takahashi, A., Okada, R., Nagao, K., Kawamata, Y., Hanyu, A., Yoshimoto, S., Takasugi, M., Watanabe, S., Kanemaki, M.T., Obuse, C. and *Hara, E.
Exosomes maintain cellular homeostasis by excreting harmful DNA from cells.
Nature Communications, 8, 15287 doi: 10.1038/NCOMMS15287 (2017).
(*Takahashi and Hara are co-corresponding to this paper.)
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*Sato, S., *Kawamata, Y., *Takahashi, A., *Imai, Y., Hanyu, A., Okuma, A., Takasugi, M., Yamakoshi, K, Sorimachi, H., Sone, S., Nishioka, Y, Ohtani, N. and Hara, E.
Reversing the ageing phenotypes of klotho mice by ablating the p16INK4a tumour suppressor.
Nature Communications, 6: 7035 doi: 10.1038/ncomms8035 (2015).
(*Sato, Kawamata, Takahashi and Imai contributed equally to this paper.)
- Imai, Y., Takahashi, A., Hanyu, A., Hori, S., Sato, S., Naka, K., Hirao, A., Ohtani, N. and Hara, E.
Crosstalk between the Rb Pathway and AKT Signaling Forms a Quiescence-Senescence Switch.
Cell Rep., 7, 194-207 (2014)
- Takahashi, A., Imai, Y., Yamakoshi, K., Kuninaka, S., Ohtani, N., Yoshimoto, S., Hori, S., Tachibana, M., Anderton, E., Takeuchi, T., Shinkai, Y., Peters, G., Saya, H. & Hara, E.
DNA Damage Signaling Triggers Degradation of Histone Methyltransferases through APC/C(Cdh1) in Senescent Cells.
Mol Cell. 45, 123-131 (2012)
- Fukuyo, Y., Takahashi, A., Hara, E., Horikoshi, N., Pandita, T.K. & Nakajima, T.
E2FBP1 antagonizes the p16(INK4A)-Rb tumor suppressor machinery for growth suppression and cellular senescence by regulating promyelocytic leukemia protein stability.
Int J Oral Sci. 3, 200-208 (2011)
- Takeuchi, S., Takahashi, A., Motoi, N., Tajima, T., Yamakoshi, K., Yoshimoto, S., Hirao, A., Yanagi, S., Fukami, K., Ishikawa, Y., Sone, S. & Hara, E.
Intrinsic cooperation between p16INK4a and p21Waf1/Cip1 in the onset of cellular senescence and tumor suppression in vivo.
Cancer Res. 70, 9381-9390 (2010)
- *Yamakoshi, K., *Takahashi, A., Hirose, F., Nakayama, R., Ishimaru, N., Kubo, Y., Mann, D.J., Ohmura, M., Hirao, A., Saya, H., Arase, S., Hayashi, Y., Nakao, K., Matsumoto, M., Ohtani, N. & Hara, E.
Real-time in vivo imaging of p16Ink4a reveals crosstalk with p53
J. Cell Biol., 186, 393-407 (2009)
(*Yamakoshi and Takahashi contributed equally to this paper.)
- Ohtani, N., Imamura, Y., Yamakoshi, K., Hirota, F., Nakayama, R., Kubo, Y., Ishimaru, N., Takahashi, A., Hirao, A., Shimizu, T., Mann, D.J., Saya, H., Hayashi, Y., Arase, S., Matsumoto, M., Nakao, K. & Hara, E.
Visualizing the dynamics of p21Waf1/Cip1 cyclin-dependent kinase inhibitor expression in living mice
Proc. Natl. Acad. Sci. USA, 104, 15034-15039 (2007)
- Takahashi, A., Ohtani, N., Yamakoshi, K., Iida, S., Tahara, H.,Nakayama, K., Nakayama, K.I., Ide, T., Saya, H. & Hara, E.
Mitogenic signalling and the p16INK4a/Rb pathway co-operate to enforce irreversible cellular senescence
Nature Cell Biol., 8, 1291-1297 (2006)
- Higashino, F., Aoyagi, M., Takahashi, A., Ishino, M., Taoka, M., Isobe, T., Kobayashi, M., Totsuka, Y., Kohgo, T. & Shindoh, M.
Adenovirus E4orf6 targets pp32/LANP to control the fate of ARE-containing mRNAs by perturbing the CRM1-dependent mechanism.
J. Cell Biol., 170, 15-20 (2005)
- Maehara, K., Yamakoshi, K., Ohtani, N., Kubo, Y., Takahashi, A., Arase, S., Jones, N. & Hara, E.
Reduction of total E2F/DP activity induces senescence-like cell cycle arrest in cancer cells lacking functional pRB and p53.
J. Cell Biol., 167, 553-560 (2005)
- Takahashi, A., Higashino, F., Aoyagi, M., Yoshida, K., Itoh, M., Kyo, S., Ohno, T., Taira, T., Ariga, H., Nakajima, K., Hatta, M., Kobayashi, M., Sano, H., Kohgo, T. & Shindoh, M.
EWS/ETS fusions activate telomerase in Ewing’s tumors.
Cancer Res., 63, 8338-8344 (2003)
- Aoyagi, M., Higashino, F., Yasuda, M., Takahashi, A., Sawada, Y., Totsuka, Y., Kohgo, T., Sano, H., Kobayashi, M. & Shindoh, M.
Nuclear export of the adenovirus E4orf6 protein is necessary for its ability to antagonize the apoptotic activity of the BH3-only proteins.
Oncogene, 22, 6919-6927 (2003)