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MEIS1-mediated transactivation of synaptotagmin-like 1 promotes CXCL12/CXCR4 signaling and leukemogenesis

Meis1 is a TALE-class homeodomain transcription factor that is important in hematopoiesis, vasculogenesis, cardiac development and eye development. Meis1 is also important for Hox functions in myeloid leukemogenesis. However, its functions in leukemogenesis and the significance of its cooperation with Hox have not been clarified..More

Laboratories

Physics

Temporarily closed.

Biochemistry

Temporarily closed.

Chemotherapy

Developing safe and effective anti-cancer drugs and treatments

Pathology Project for Molecular Targets

Our aim is to create a novel field of pathology for patients, therapy-oriented pathology.

Cancer Genomics

Our aims are to establish personalized medicine and novel bioinformatics methodology.

Protein Engineering

Our aim is to develop cancer diagnosis methods through the use of artificial proteins.

Genetic Diagnosis

We aim to elucidate the mechanisms of breast oncogenesis and establish genetic diagnosis.

Carcinogenesis

We will explore novel approach for cancer treatment by clarifying carcinogenic mechanism.

Project for Cancer Epigenomics

We aim to understand how and why genome-wide epigenetic states are changed during cancer initiation and progression.

Project for Cellular Senescence

We try to understand the molecular mechanism of aging and age-associated pathology including cancer through the research targeting cellular senescence.

Cancer Biology

We are studying how chromatin and nuclear structures contribute to epigenetic regulation and cancer development.

Experimental Pathology

We aim to elucidate the mechanisms underlying chromosomal instability in cancer cells.

Cell Biology

We investigate carcinogenesis in vivo to develop novel strategies for cancer prevention and treatment.

Pathology

Our activities involve research on cancer prevention and diagnosis for JFCR Hospital.

Recent Publications

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