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2024
- Machitani, M., Nomura, A., Yamashita, T., Yasukawa, M., Ueki, S., Fujita, K., Ueno, T., Yamashita, A., Tanzawa, Y., Watanabe, M., Taniguchi, T., Saitoh, N., Kaneko, S., Kato, Y., Mano, H., Masutomi, K. Maintenance of R-loop structures by phosphorylated hTERT preserves genome integrity. Nature Cell Biol. 26:932-945, 2024, doi: 10.1038/s41556-024-01427-6.
- Palihati, M., Saitoh,, N. RNA in chromatin organization and nuclear architecture. Current Opinion in Genetics & Development, 86:102176, 2024, doi:10.1016/j.gde.2024.102176.
2023
- Wakao S, Saitoh N, Awazu A. Mathematical model of structural changes in nuclear speckle.Biophysics and Physicobiology, 20(2):e200020, 2023, doi:10.2142/biophysico.bppb-v20.0020.
- Sundararajan S, Park H, Kawano S, Johansson M, Lama B, Saito-Fujita T, Saitoh N, Arnaoutov A, Dasso M, Wang Z, Keifenheim D, Clarke DJ, Azuma Y. Methylated histones on mitotic chromosomes promote Topoisomerase IIα function for high-fidelity chromosome segregation. iScience, 26(5):106743, 2023, doi:10.1016/j.isci.2023.106743.
- Smallwood K, Watt KEN, Ide S, Baltrunaite K, Inskeep K, Adam M, Begtrup A, Bertola DR, Cho M, Demmer L, Demo E, Devinsky O, Gallagher E, Guillen MJS, Keller-Ramey J, Keren B, Ladda R, Mardy A, McLaughlin H, McWalters K, Person R, Schnur R, Skorvanek M, Slavotinek A, Sullivan BR, Stark Z, Symonds J, Wenger T, Saitoh N, Whalen S, Willaert R, Zech M, Zeidler S, Stottmann RW, Trainor PA, Weaver KN. POLR1A variants underlie phenotypic heterogeneity in neural, craniofacial, and cardiac anomalies. The American Journal of Human Genetics, S0002-9297(23)00098-8,2023, doi:10.1016/j.ajhg.2023.03.014
2022
- Suzuki H, Abe R, Shimada M, Hirose T, Hirose H, Noguchi K, Ike Y, Yasui N, Furugori K, Yamaguchi Y, Toyoda A, Suzuki Y, Yamamoto T, Saitoh N, Sato S, Tomomori-Sato C, Conaway R, Conaway J, Takahashi H. The 3′ Pol II pausing at replication-dependent histone genes is regulated by Mediator through Cajal bodies’ association with histone locus bodies. Nature Commun., 13(1):2905, 2022, doi: 10.1038/s41467-022-30632-w.
- Fukuoka M, Ichikawa Y, Osako T, Fujita T, Baba S, Takeuchi K, Tsunoda N, Ebata T, Ueno T, Ohno S, *Saitoh N. The ELEANOR non-coding RNA expression contributes to cancer dormancy and predicts late recurrence of ER-positive breast cancer. Cancer Science, 2022, doi: 10.1111/cas.15373.
- Matsumori1 H, *Watanabe K, Tachiwana H, Fujita T, Ito Y, Tokunaga M, Sakata-Sogawa K, Osakada H, Haraguchi T, Awazu A, Ochiai H, Sakata Y, Ochiai K, Toki T, Ito E, Goldberg I, G, Tokunaga K, Nakao M, Saitoh N. Ribosomal protein L5 facilitates rDNA-bundled condensate and nucleolar assembly. Life Scilence Alliance, 5(7):e202101045, 2021, doi: 10.26508/lsa.202101045.
2021
- Maehara K, Tomimatsu K, Harada A, Tanaka K, Sato S, Fukuoka M, Okada S, Handa T, Kurumizaka H, Saitoh N, Kimura H, *Ohkawa Y. Modeling population size independent tissue epigenomes by ChIL-seq with single thin sections. Molecular Systems Biology, 17:e10323, 2021, doi: 10.15252/msb.202110323.
- Jibiki K, Kodama T, Suenaga A, Kawase Y, Shibazaki N, Nomoto S, Nagasawa S, Nagashima M, Shimodan S, Kikuchi R, Okayasu M, Takashita R, Mehmood R, Saitoh N, Yoneda Y, Akagi K, *Yasuhara N. Importin α2 association with chromatin: Direct DNA binding via a novel DNA-binding domain. Genes to Cells, 00:1-22, 2021, doi: 10.1111/gtc.12896.
- Tachiwana H, Dacher M, Maehara K, Harada A, Seto Y, Katayama R, Ohkawa Y, Kimura H, Kurumizaka H, Saitoh N. Chromatin structure-dependent histone incorporation revealed by a genome-wide deposition assay. eLife, 10:e66290, 2021, doi:10.7554/eLife.66290.
- Ichikawa Y, Saitoh N. Shaping of genome by long noncoding RNAs. In books Cytogenomics, 357-372, 2021, doi:10.1016/B978-0-12-823579-9.00018-7.
- Tachiwana H, Saitoh N*. Nuclear long non-coding RNAs as epigenetic regulators in cancer. Current medicinal chemistry, 28(25):5098-5109, 2021, doi:10.2174/0929867328666210215114506.
- Saitoh N*, Gasser S M. Nadeshiko revisited: The situation of women in Japanese research and the measures taken to increase their representation. EMBO Rep, 22:e52528, 2021, doi:10.15252/embr.202152528.
2020
- Nozawa R, Yamamoto T, Takahashi M, Tachiwana H, Maruyama R, Hirota T, Saitoh N*. Nuclear microenvironment in cancer: control through liquid-liquid phase separation. Cancer Sci, 111(9):3155-3163, 2020, doi:10.1111/cas.14551.
- Yamamoto T#, Hirosue A#*, Nakamoto M, Yoshida R, Sakata J, Matsuoka Y, Kawahara K, Nagao Y, Nagata M, Takahashi N, Hiraki A, Shinohara M, Nakao M, Saitoh N*, Nakayama H. BRD4 promotes metastatic potential in oral squamous cell carcinoma through the epigenetic regulation of the MMP2 gene. British Journal of Cancer, 123:580-590, 2020, doi:10.1038/s41416-020-0907-6.
- Ochiai H, Hayashi T, Umeda M, Yoshimura M, Harada A, Shimizu Y, Nakano K, Saitoh N, Liu Z, Yamamoto T, Okamura T, Ohkawa Y, Kimura H, Nikaido I*. Genome-wide analysis of kinetic properties of transcriptional bursting in mammalian cells. Science Advances, 6(25):eaaz6699, 2020, doi:10.1126/sciadv.aaz6699.
- Tachiwana H, Yamamoto T, Saitoh N*.Gene regulation by non-coding RNAs in the 3D genome architecture. Current Opinion in Genetics and Development, 61:69-74, 2020, doi:10.1016/j.gde.2020.03.002.
- Fujita R, Yamamoto T, Arimura Y, Fujiwara S, Tachiwana H, Ichikawa Y, Sakata S, Yang L, Maruyama R, Hamada M, Nakao M, Saitoh N*, Kurumizaka H*. Nucleosome destabilization by nuclear non-coding RNAs. Commun. Bioloy, 3(1):60, 2020, doi:10.1038/s42003-020-0784-9.
- Yasuda Y, Tokunaga K, Koga T, Goldberg I, Sakamoto C, Saitoh N*, Nakao M*. Computational analysis of morphological and molecular features in gastric cancer tissues. Cancer Medicine, 9(6):2223-2234, 2020, doi:10.1002/cam4.2885.
- Miyazaki K, Ichikawa Y, Saitoh N, Saitoh H*. Three Types of Nuclear Envelope Assemblies Associated with Micronuclei. Cell Bio, 9:14-28, 2020, doi:10.4236/cellbio.2020.91002.
2019
- Abdalla M O A, Yamamoto T, Maehara K, Ohkawa Y, Miura H, Hiratani I, Nakayama H, Nakao M, Saitoh N*. The Eleanor ncRNAs activate the topological domain of the ESR1 locus to balance against apoptosis. Nat. Commun, 10:Article No.3778, 2019, doi: 10.1038/s41467-019-11378-4.
- Yamamoto T, Saitoh N*. Non-coding RNAs and chromatin domains. Curr Opin Cell Biol, 58:26-33, 2018, doi:10.1016/j.ceb.2018.12.005.
2018
- Yamamoto T, Sakamoto C, Tachiwana H, Kumabe M, Matsui T, Yamashita T, Shinagawa M, Ochiai K, Saitoh N*, Nakao M*. Endocrine therapy-resistant breast cancer model cells are inhibited by soybean glyceollin I through Eleanor non-coding RNA. Science Report, 8:15202, 2018, doi: 10.1038/s41598-018-33227-y.
- Ichikawa Y, Saitoh N, Kaufman P D*. An asymmetric centromeric nucleosome. eLife, 7:e37911, 2018, doi: 10.7554/eLife.37911.
2017
- Takagi M, Ono Y, Natsume T, Sakamoto C, Nakao M, Saitoh N, Kanemaki M T, Hirano T, Imamoto N. Ki-67 and condensins support the integrity of mitotic chromosomes through distinct mechanisms. J. Cell Sci, 131(6):jcs212092, 2018, doi:10.1242/jcs.212092.
- Dobrucki J, Saitoh N. The 4D Nucleome in Kraków-prospects for an emerging field. Nucleus, 8(5):447-448, doi:10.1080/19491034.2017.1347243.
- Ono T, Sakamoto C, Nakao N, Saitoh N, Hirano T*. Condensin II plays an essential role in reversible assembly of mitotic chromosomes in situ. Mol. Biol. Cell, 28:2875-2886, 2017, doi:10.1091/mbc.E17-04-0252
- Wang X, Liang S, Sun, Y, Li H, Endo F, Nakao M, Saitoh N*,Wu L*. Analysis of estrogen receptor beta gene methylation in autistic males in a Chinese Han population. Metab Brain Dis, 32:1033-1042, 2017, doi 10.1007/s11011-017-9990-7 *corresponding author
- Tanaka H, Takebayashi SI, Sakamoto A, Igata T, Nakatsu Y, Saitoh N, Hino S, Nakao M*. The SETD8/PR-Set7 Methyltransferase Functions as a Barrier to Prevent Senescence-Associated Metabolic Remodeling. Cell Rep, 18:2148-2161, 2017. doi: 10.1016/j.celrep.2017.02.021
~2016
- Tomita S, Abdalla M O A, Fujiwara S, Yamamoto T, Iwase H, Nakao M*, Saitoh N*. Roles of long non-coding RNAs in chromosome domains. Wiley Interdisciplinary Review RNA, 2016, doi:10.1002/wrna.1384 *corresponding author
- Nakayama T, Saitoh N, Morotomi-Yano K, Yano K I, Nakao M, Saitoh H*. Nuclear extrusion precedes discharge of genomic DNA fibers during tunicamycin-induced neutrophil extracellular trap-osis (NETosis)-like cell death in cultured human leukemia cells. Cell Biol Int, 40(5):597-602, 2016, doi:10.1002/cbin.10594
- Matsumoto A, Sakamoto C, Matsumori H, Katahira J, Yasuda Y, Yoshidome K, Tsujimoto M, Goldberg I G, Matsuura N, Nakao M, Saitoh N*, Hieda M*. Loss of the integral nuclear envelope protein SUN1 induces alteration of nucleoli. Nucleus, 7:68-83, 2016, doi:10.1080/19491034.2016.1149664 *corresponding author
- Kitamura H, Matsumori H, Kalendova A, Hozak P, Goldberg I G, Nakao M, Saitoh, N*, Harata M*. The actin family protein ARP6 contributes to the structure and the function of the nucleolus. Biochem. Biophys. Res. Commun, 464(2):554-560, 2015, doi:10.1016/j.bbrc.2015.07.005 *corresponding author
- Tomita S, Abdalla M O A, Fujiwara S, Matsumori H, Maehara K, Ohkawa Y, Iwase H, Saitoh N*, Nakao M*. A cluster of noncoding RNAs activates the ESR1 locus during breast cancer adaptation. Nat.Commun, 6:696, 2015, doi:10.1038/ncomms7966 *corresponding author
- Tokunaga K, Saitoh N*, Goldberg I G, Sakamoto C, Yasuda Y, Yoshida Y, Yamanaka S, Nakao M*. Computational image analysis of colony and nuclear morphology to evaluate human induced pluripotent stem cells. Sci. Rep, 4:6996, 2014, doi:10.1038/srep06996 *corresponding author
- Sasai N, Saitoh N, Saitoh H, Nakao M*. The transcriptional cofactor MCAF1/ATF7IP is involved in histone gene expression and cellular senescence. PLoS ONE, 8(7):e68478, 2013, doi:10.1371/journal.pone.0068478
- Hirosue A, Ishihara K, Tokunaga K, Watanabe T, Saitoh N, Nakamoto M, Chandra T, Narita M, Shinohara M, Nakao M. Quantitative assessment of higher-order chromatin structure of the INK4/ARF locus in human senescent cells. Aging Cell, 11:553-556, 2012.
- Saitoh N*, Sakamoto C, Hagiwara M, Agredano-Moreno L T, Jiménez-García L T, Nakao M. The distribution of phosphorylated SR proteins and alternative splicing are regulated by RANBP2. Mol. Biol. Cell, 23:1115-1128, 2012. *corresponding author
- Tei S, Saitoh N, Funahara T, Iida I, Nakatsu Y, Kinoshita K, Kinoshita Y, Saya H, Nakao M*. Simian virus 40 large T antigen targets the microtubule- stabilizing protein TACC2. J. Cell Sci, 122:3190-3198, 2009.
- Liu L, Ishihara K, Ichimura T, Fujita N, Hino S, Tomita S, Watanabe S, Saitoh N, Ito T, Nakao, M*. MCAF1/AM is involved in Sp1-mediated maintenance of cancer-associated telomerase activity. J. Biol. Chem, 284:5165-5174, 2009.
- Aoto T, Saitoh N*, Sakamoto Y, Watanabe S, Nakao M*. Polycomb group-associated chromatin is reproduced in post-mitotic G1 phase and required for S-phase progression. J. Biol. Chem, 283 18905-18915, 2008. *corresponding author
- Ueda Y, Watanabe S, Tei S, Saitoh N, Kuratsu J I, Nakao M*. High mobility group protein HMGA1 inhibits retinoblastoma protein-mediated cellular G0 arrest. Cancer Sci, 98:1893-1901, 2007.
- Aoto T, Saitoh N, Ichimura T, Niwa H, Nakao M*. Nuclear and chromatin reorganization in the MHC-Oct3/4 locus at developmental phases of embryonic stem cell differentiation. Dev. Biol, 208:354-367, 2006.
- Saitoh N, Uchimura U, Tachibana T, Sugahara S, Saitoh H, Nakao M*. In situ SUMOylation analysis reveals a modulatory role of RanBP2 in the nuclear rim and PML bodies. Exp. Cell Res, 312:1418-1430, 2006.
- Saitoh N, Spahr C S, Patterson S D, Bubulya P, Neuwald A F, Spector D L*. Proteomics analysis of interchromatin granule clusters. Mol. Biol. Cell, 15:3876-3890, 2004.
- Nishijima H, Nishitani H, Saitoh N, Nishimoto T*. Caffeine mimics adenine and 2’-deoxyadenosine, both of which inhibit the guanin-nucleotide exchange activity of RCC1 and the kinase activity of ATR. Genes to Cells, 8:423-435, 2003.
- Matsuzaki K, Minami T, Tojo M, Honda Y, Saitoh N, Nagashiro S, Saya H, Nakao M*. PML-nuclear bodies are involved in cellular serum response. Genes to Cells, 8:275-286, 2003.
- Saitoh N, West A, Recillas-Targa F, Pikaart M J, Felsenfeld G*. Structural and functional conservation at the boundaries of the chicken b-globin domain. EMBO J, 19:2315-2322, 2000.
- Bulger M, von Doorninck J H, Saitoh N, Telling A, Farrell C, Bender M A, Felsenfeld G, Axel R, Groudine M*. Conservation of sequence and structure flanking the mouse and human beta-globin loci: the beta-globin genes are embedded within an array of odorant receptor genes. Proc Natl Acad Sci U S A, 96:5129-5134, 1999.
- Bell A, Boyes J, Chung J, Pikaart M, Prioleau M N, Recillas F, Saitoh N, Felsenfeld G*. The establishment of active chromatin domains. Cold Spring Harb Symp Quant Biol, 63:509-514, 1998.
- Bell A C, Pikaart M J, Prioleau M N, Rcillas-Targa F, Saitoh N, West A G, Felsenfeld G*. Insulators and boundaries in the chicken b-globin locus. BCMD, 24(22) 464-465, 1998.
- Saitoh N, Goldberg I G, Earnshaw W C*. The SMC proteins and the coming of age of the chromosome scaffold hypothesis. Bio Essays. 17:759-766, 1995.
- Saitoh N, Goldberg I G, Wood E R, Earnshaw W C*. ScII: An abundant chromosome scaffold protein is a member of a family of putative ATPases with an unusual predicted tertiary structure. J. Cell Biol, 127:303-318, 1994.
- Ma X, Saitoh N, Curtis P*. Purification and characterization of a nuclear DNA-binding factor complex containing topoisomerase II and chromosome scaffold protein 2. J. Biol. Chem, 268 6182-6188, 1993.
- Pluta A F, Saitoh N, Goldberg I, Earnshaw W C*. Identification of a subdomain of CENP-B that is necessary and sufficient for localization to the human centromere. J. Cell Biol, 116:1081-1093, 1992.
- Ishihara H*, Hara N, Iwabuchi T. Molecular cloning and expression in Escherichia coli of the Bacillus licheniformis Bacitracin Synthetase 2 Gene. J. Bacteriol, 171:1705-1711, 1989.