Realizing individualized cancer treatment through patient genome sequencing

Recent Publications

Huang, T., Takagi, S., Koike, S. and Katayama, R.
Inhibition of anti-apoptotic Bcl-2 family members promotes synergistic cell death with ER stress inducers by disrupting autophagy in glioblastoma.
Cell Death Discov., in press (2025)
Ishiguro, K., Kitajima, H., Niinuma, T., Maruyama, R., Tsukahara, T., Hirohashi, Y., Takaya, A., Kumegawa, K., Yoshido, A., Sekiguchi, S., Sasaki, H., Yorozu, A., Toyota, M., Kai, M., Torigoe, T., Nakase, H. and Suzuki, H.
DOT1L inhibition reprograms innate immunity to potentiate immunomodulatory drug responses in multiple myeloma.
Cancer Lett., 217941 (2025)
Sudo, G., Yamamoto, E., Niinuma, T., Saito, M., Kitajima, H., Ishiguro, K., Yorozu, A., Toyota, M., Aoki, H., Mitsuhashi, K., Yoshii, S., Yamano, H. O., Idogawa, M., Maruyama, R., Sugai, T., Nakase, H. and Suzuki, H.
Concurrent hypermethylation of CpG islands and hypomethylation of CpG-poor regions are associated with gastric cancer risk after Helicobacter pylori eradication.
Gastric Cancer, in press (2025)
Iesato, A., Suzuka, J., Otsuji, K., Osako, T., Yamashita, N., Inoue, Y., Maeda, T., Uehiro, N., Yoshida, K., Takahashi, Y., Kumegawa, K., Saeki, S., Yang, L., Tsuchiya, A., Sakiyama, K., Tanaka, M., Sakai, T., Ohno, S., Noda, T., Ueno, T. and Maruyama, R.
Axillary adipose tissue-derived lymphatic endothelial cells exhibit distinct transcriptomic signatures reflecting lymphatic invasion status in breast cancer.
Breast Cancer Res., 27, 109 (2025)
Wang, W., Kumegawa, K., Chapman, O. S., Shiraishi, R., Xiao, Z., Okonechnikov, K., Sun, Y., Pfister, S. M., Feng, W., Uesaka, N., Hoshino, M., Takahashi, S., Korshunov, A., Chavez, L., Maruyama, R. and Kawauchi, D.
Chromatin Modification Abnormalities by CHD7 and KMT2C Loss Promote Medulloblastoma Progression.
Cell Rep., 44, 115673 (2025)

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