Cancer Instltute

MEIS1-mediated transactivation of synaptotagmin-like 1 promotes CXCL12/CXCR4 signaling and leukemogenesis

Meis1 is a TALE-class homeodomain transcription factor that is important in hematopoiesis, vasculogenesis, cardiac development and eye development. Meis1 is also important for Hox functions in myeloid leukemogenesis. However, its functions in leukemogenesis and the significance of its cooperation with Hox have not been clarified..More

Failure in the process of DNA replication leads to genetic changes in daughter cells and potentially causes cancer predisposition in our body.

Temporarily closed.

Temporarily closed.

Developing safe and effective anti-cancer drugs and treatments

Our aim is to create a novel field of pathology for patients, therapy-oriented pathology.

Our aims are to establish personalized medicine and novel bioinformatics methodology.

We aim to elucidate the mechanisms of breast oncogenesis and establish genetic diagnosis.

By recognizing cancer as a highly diverse tissue, we aim for radical cure of cancer by simultaneously blocking multiple targets.

We aim to understand how and why genome-wide epigenetic states are changed during cancer initiation and progression.

We try to understand the molecular mechanism of aging and age-associated pathology including cancer through the research targeting cellular senescence.

We are studying how chromatin and nuclear structures contribute to epigenetic regulation and cancer development.

We aim to elucidate the mechanisms underlying chromosomal instability in cancer cells.

We investigate carcinogenesis in vivo to develop novel strategies for cancer prevention and treatment.

Our activities involve research on cancer prevention and diagnosis for JFCR　Hospital.

Bernardi, F., Torrejon, J., Basili, I., Van Ommeren, R., Marsaud, V., Yu, H., Talbot, J., Souphron, J., Indersie, E., Forget, A., Bonneau, B., Massiot, A., Alcazar, C., Figeac, L., Bonerandi, E., Cancila, G., Sirbu, O., Yadav, N., Mohanakrishnan, D., Lombard, B., Loew, D., Poullet, P., Liva, S., Lovino, M., Lin, I. H., Nakashima, T., Gharsalli, T., Nicolas, P. A., Yubuki, N., Ribas, R. A., Colsch, B., Chu-Van, E., Castelli, F., Sampaio, J. L., Leboucher, S., Lasgi, C., Besse, L., Soler, M. N., Lo Re, V., Planque, N., Abeysundara, N., Balin, P., Wang, H., Su, H., Wu, X., Cavalli, F. M. G., Saulnier, O., Ficarra, E., Di Marcotullio, L., Kumegawa, K., Maruyama, R., Kawauchi, D., Picard, D., Remke, M., Riffaud, L., Puiseux, C., Bouchoucha, Y., Huybrechts, S., Simbozel, M., Bourdeaut, F., Varlet, P., Puget, S., Blauwblomme, T., Andrianteranagna, M., Planchon, J. M., Dugourd, A., Saez-Rodriguez, J., Barillot, E., Servant, N., Martignetti, L., Rich, J., Kool, M., Pfister, S. M., Agnihotri, S., Suzuki, H., Fanjul, M., Wang, W. J., Tsai, J. W., Sun, R. C., Beccaria, K., Dufour, C., Sarry, J. E., Michealraj, K. A., Taylor, M. D. and Ayrault, O.

Multiomic integration reveals tumoral heterogeneity of lipid dependence within lethal group 3 medulloblastoma.
Cancer Cell, 44, 383-404.e18 (2026)
Miyatake, Y., Kamakura, T., Ikawa, T., Yanagiya, R., Kotaki, R., Kameda, K., Nasu, R. K., Okuyama, K., Hirano, K. I., Hosokawa, H., Hozumi, K., Ohtsuka, M., Kisikawa, T., Shibata, C., Otsuka, M., Maruyama, R., Ando, K., Kurosaki, T., Kawamoto, H. and Kotani, A.

A single microRNA miR-195 rescues the arrested B cell development induced by EBF1 deficiency.
eLife, 13, RP101510 (2026)
Furukawa, T., Kumegawa, K., Miyata, K., Takamatsu, M., Iesato, A., Saeki, S., Yang, L., Shibata, C., Takahara, T., Masuda, K., Mie, T., Okamoto, T., Takeda, T., Sasaki, T., Ozaka, M., Tanaka, M., Takahashi, S., Noda, T., Yao, R., Sasahira, N. and Maruyama, R.

Patient-derived orthotopic xenograft models recapitulate the peritoneal dissemination of pancreatic cancer and delineate its transcriptional and regulatory programs.
J. Exp. Clin. Cancer Res., in press (2026)
Nakayama, C., Fang, Q., Daigaku, Y., Aoi, Y., Ito, S., Takahashi, M., Shimatani, R., Minamisawa, T., Ozturk, Y., Kimura, H., Shilatifard, A., Tellier, M. and Nojima, T.

NELF prevents transcriptional readthrough into DNA replication zones in cancer cells.
EMBO Rep., in press (2026)
Tanaka, Y., Sakahara, M., Yamanaka, H., Natsume, Y., Kusama, D., Kumegawa, K., Yoshikawa, H., Abe, Y., Okabayashi, K., Matui, S., Kitagawa, Y., Koshikawa, N., Osumi, H., Shinozaki, E., Nagayama, S., Adachi, J., Maruyama, R. and Yao, R.

Ribosome biogenesis as a potential therapeutic target in KRAS mutant colorectal cancer.
Nat. Commun., 17, 1224 (2026)