Cancer Chemotherapy Center

Secreted PD-L1 variants mediate resistance to PD-L1 blockade therapy in non-small cell lung cancer More

To identify molecular targets and compounds for cancer therapy

We discover and develop the novel molecular-targeted drugs by using Cancer Cell Informatics.

Telomeres, cell immortality and cancer stemness as therapeutic targets

We promote genome science-driven research for targeted therapy and personalized medicine

We focus the research between clinical samples and imaging the molecular target

Kato, Y., Kunimasa, K., Takahashi, M., Harada, A., Nagasawa, I., Osawa, M., Sugimoto, Y. and Tomida, A.

GZD824 inhibits GCN2 and sensitizes cancer cells to amino acid starvation stress.
Molecular Pharmacology, in press (2020)
Nosol, K., Romane, K., Irobalieva, R. N., Alam, A., Kowal, J., Fujita, N. and Locher, K. P.

Cryo-EM structures reveal distinct mechanisms of inhibition of the human multidrug transporter ABCB1.
Proc. Natl. Acad. Sci. U. S. A., in press (2020)
Sonoda, T., Yanagitani, N., Suga, K., Yoshizawa, T., Nishikawa, S., Kitazono, S., Horiike, A., Shiba, K., Ishizuka, T., Nishio, M. and Matsusaka, S.

A novel system to detect circulating tumor cells using two different size-selective microfilters.
Anticancer Res., 40, 5577-5582 (2020)
Akiyoshi, T., Gotoh, O., Tanaka, N., Kiyotani, K., Yamamoto, N., Ueno, M., Fukunaga, Y. and Mori, S.

T-cell complexity and density are associated with sensitivity to neoadjuvant chemoradiotherapy in patients with rectal cancer.
Cancer Immunol. Immunother., in press (2020)
Nozawa, R. S., Yamamoto, T., Takahashi, M., Tachiwana, H., Maruyama, R., Hirota, T. and Saitoh, N.

Nuclear microenvironment in cancer: control through liquid-liquid phase separation.
Cancer Sci., in press (2020)