Cancer Chemotherapy Center

Secreted PD-L1 variants mediate resistance to PD-L1 blockade therapy in non-small cell lung cancer More

To identify molecular targets and compounds for cancer therapy

We discover and develop the novel molecular-targeted drugs by using Cancer Cell Informatics.

Telomeres, cell immortality and cancer stemness as therapeutic targets

We promote genome science-driven research for targeted therapy and personalized medicine

We focus the research between clinical samples and imaging the molecular target

Nagasawa, I., Koido, M., Tani, Y., Tsukahara, S., Kunimasa, K. and Tomida, A.

Disrupting ATF4 expression mechanisms provides an effective strategy for BRAF-targeted melanoma therapy.
iScience, in press (2020)
Okamoto, Y., Saito, T., Tani, Y., Toki, T., Hasebe, A., Koido, M. and Tomida, A.

The kinase PERK represses translation of the G protein-coupled receptor LGR5 and receptor tyrosine kinase ERBB3 during ER stress in cancer cells.
J. Biol. Chem., in press (2020)
Miyazaki, K., Ichikawa, Y., Saitoh, N. and Saitoh, H.

Three types of nuclear envelope assemblies associated with micronuclei.
CellBio, in press (2020)
Loo, T. M., Miyata, K., Tanaka, Y. and Takahashi, A.

Cellular senescence and senescence-associated secretory phenotype via the cGAS-STING signaling pathway in cancer.
Cancer Sci., 111, 304-311 (2020)
Tanaka, M., Homme, M., Yamazaki, Y., Ae, K., Matsumoto, S., Subramanian, S. and Nakamura, T.

Cooperation between SS18-SSX1 and miR-214 in synovial sarcoma development and progression.
Cancers, 12, 324 (2020)