Cancer Chemotherapy Center

Innovating safe and effective anti-cancer drugs and treatments

Gilteritinib overcomes lorlatinib resistance in ALK-rearranged cancer　 More

To identify molecular targets and compounds for cancer therapy

We discover and develop the novel molecular-targeted drugs by using Cancer Cell Informatics.

Telomeres, cell immortality and cancer stemness as therapeutic targets

We promote genome science-driven research for targeted therapy and personalized medicine

We focus the research between clinical samples and imaging the molecular target

Sasaki, N., Suezawa, T., Kitano, S., Katayama, R. and Matsusaki, M.

Hierarchical collagen nanofiber gels recapitulate a physiologically relevant tumor stromal microenvironment.
Adv. Healthc. Mater., e00877 (2026)
Sakahara, M., Okamoto, T., Kumegawa, K., Natsume, Y., Kusama, D., Yamanaka, H., Komatsuzaki, R., Yaginuma, K., Srivastava, U., Takahashi-Kanemitsu, A., Susaki, E. A., Obama, K., Nagayama, S., Maruyama, R. and Yao, R.

Colorectal cancer co-opts an epidermal wound healing program during metastasis to generate disseminated tumor cells.
Nat. Commun., in press (2026)
Noda, T., Shirahama, H., Tani, Y. and Tomida, A.

Pharmacological blockade of oncogenic MAPK activators drives resistance to cystine deprivation with lipid redox remodeling.
Biochem. Biophys. Res. Commun., 832, 154376 (2026)
Yoshitake, H., Negoto, T., Moritsubo, M., Furuta, T., Jo, M., Hirota, T., Sakata, K., Nakamura, H. and Morioka, M.

Chromosomal instability is associated with paradoxical cGAS upregulation and impaired STING signaling shaping the immune microenvironment in glioblastoma.
Neurooncol. Adv., vdag179 (2026)
Hara, T., Meng, S., Konno, M., Nishida, N., Koseki, J., Meguro, K., Kawano, Y., Morie, T., Dan, S., Satoh, T., Akai, S., Tsujikawa, K., Eguchi, H., Mori, M., Miura, Y., Nishiyama, N. and Ishii, H.

Identification of novel small-molecule inhibitors targeting KDM5B and evaluation of their antitumour effects.
Cancer Med., 15, e72058 (2026)