Cancer Chemotherapy Center

Brigatinib combined with anti-EGFR antibody overcomes osimertinib resistance in EGFR-mutated non-small-cell lung cancer More

To identify molecular targets and compounds for cancer therapy

We discover and develop the novel molecular-targeted drugs by using Cancer Cell Informatics.

Telomeres, cell immortality and cancer stemness as therapeutic targets

We promote genome science-driven research for targeted therapy and personalized medicine

We focus the research between clinical samples and imaging the molecular target

Okamoto, K., Ohishi, T., Kuroiwa, M., Iemura, S., Natsume, T. and Seimiya, H.

MERIT40-dependent recruitment of tankyrase to damaged DNA and its implication for cell sensitivity to DNA-damaging anticancer drugs.
Oncotarget, 9, 35844-3585５ (2018)
Yonekura, R., Osako, T., Iwase, T., Ogiya, A., Ueno, T., Kitagawa, M., Ohno, S. and Akiyama, F.

Prognostic impact and possible pathogenesis of lymph node metastasis in ductal carcinoma in situ of the breast.
Breast Cancer Res. Treat., in press (2018)
Hatta, T., Iemura, S., Ohishi, T., nakayama, H., Seimiya, H., Iizuka, K., Takeda, J., Natsume, T. and Horikawa, Y.

Calpain-10 regulates actin dynamics by proteolysis of microtubule-associated protein 1B.
Sci. Rep., 8, 16756 (2018)
Yamamoto, T., Sakamoto, C., Tachiwana, H., Kumabe, M., Matsui, T., Yamashita, T., Shinagawa, M., Ochiai, K., Saitoh, N. and Nakao, M.

Endocrine therapy-resistant breast cancer model cells are inhibited by soybean glyceollin I through Eleanor non-coding RNA.
Sci. Rep., 8, 15202 (2018)
Fujiwara, C., Muramatsu, Y., Nishii, M., Tokunaka, K., Tahara, H., ueno, M., Yamori, T., Sugimoto, Y. and Seimiya, H.

Cell-based chemical fingerprinting identifies telomeres and lamin A as modifiers of DNA damage response in cancer cells.
Sci. Rep., in press (2018)