Innovating safe and effective anti-cancer drugs and treatments

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Gilteritinib overcomes lorlatinib resistance in ALK-rearranged cancer  More

Laboratories

Experimental Chemotherapy

To identify molecular targets and compounds for cancer therapy

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Molecular Pharmacology

We discover and develop the novel molecular-targeted drugs by using Cancer Cell Informatics.

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Molecular Biotherapy

Telomeres, cell immortality and cancer stemness as therapeutic targets

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Genome Research

We promote genome science-driven research for targeted therapy and personalized medicine

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Clinical Research

We focus the research between clinical samples and imaging the molecular target

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Recent Publication

  • Bernardi, F., Torrejon, J., Basili, I., Van Ommeren, R., Marsaud, V., Yu, H., Talbot, J., Souphron, J., Indersie, E., Forget, A., Bonneau, B., Massiot, A., Alcazar, C., Figeac, L., Bonerandi, E., Cancila, G., Sirbu, O., Yadav, N., Mohanakrishnan, D., Lombard, B., Loew, D., Poullet, P., Liva, S., Lovino, M., Lin, I. H., Nakashima, T., Gharsalli, T., Nicolas, P. A., Yubuki, N., Ribas, R. A., Colsch, B., Chu-Van, E., Castelli, F., Sampaio, J. L., Leboucher, S., Lasgi, C., Besse, L., Soler, M. N., Lo Re, V., Planque, N., Abeysundara, N., Balin, P., Wang, H., Su, H., Wu, X., Cavalli, F. M. G., Saulnier, O., Ficarra, E., Di Marcotullio, L., Kumegawa, K., Maruyama, R., Kawauchi, D., Picard, D., Remke, M., Riffaud, L., Puiseux, C., Bouchoucha, Y., Huybrechts, S., Simbozel, M., Bourdeaut, F., Varlet, P., Puget, S., Blauwblomme, T., Andrianteranagna, M., Planchon, J. M., Dugourd, A., Saez-Rodriguez, J., Barillot, E., Servant, N., Martignetti, L., Rich, J., Kool, M., Pfister, S. M., Agnihotri, S., Suzuki, H., Fanjul, M., Wang, W. J., Tsai, J. W., Sun, R. C., Beccaria, K., Dufour, C., Sarry, J. E., Michealraj, K. A., Taylor, M. D. and Ayrault, O.
    Multiomic integration reveals tumoral heterogeneity of lipid dependence within lethal group 3 medulloblastoma.
    Cancer Cell, 44, 383-404.e18 (2026)
  • Miyatake, Y., Kamakura, T., Ikawa, T., Yanagiya, R., Kotaki, R., Kameda, K., Nasu, R. K., Okuyama, K., Hirano, K. I., Hosokawa, H., Hozumi, K., Ohtsuka, M., Kisikawa, T., Shibata, C., Otsuka, M., Maruyama, R., Ando, K., Kurosaki, T., Kawamoto, H. and Kotani, A.
    A single microRNA miR-195 rescues the arrested B cell development induced by EBF1 deficiency.
    eLife, 13, RP101510 (2026)
  • Furukawa, T., Kumegawa, K., Miyata, K., Takamatsu, M., Iesato, A., Saeki, S., Yang, L., Shibata, C., Takahara, T., Masuda, K., Mie, T., Okamoto, T., Takeda, T., Sasaki, T., Ozaka, M., Tanaka, M., Takahashi, S., Noda, T., Yao, R., Sasahira, N. and Maruyama, R.
    Patient-derived orthotopic xenograft models recapitulate the peritoneal dissemination of pancreatic cancer and delineate its transcriptional and regulatory programs.
    J. Exp. Clin. Cancer Res., in press (2026)
  • Nakayama, C., Fang, Q., Daigaku, Y., Aoi, Y., Ito, S., Takahashi, M., Shimatani, R., Minamisawa, T., Ozturk, Y., Kimura, H., Shilatifard, A., Tellier, M. and Nojima, T.
    NELF prevents transcriptional readthrough into DNA replication zones in cancer cells.
    EMBO Rep., in press (2026)
  • Tanaka, Y., Sakahara, M., Yamanaka, H., Natsume, Y., Kusama, D., Kumegawa, K., Yoshikawa, H., Abe, Y., Okabayashi, K., Matui, S., Kitagawa, Y., Koshikawa, N., Osumi, H., Shinozaki, E., Nagayama, S., Adachi, J., Maruyama, R. and Yao, R.
    Ribosome biogenesis as a potential therapeutic target in KRAS mutant colorectal cancer.
    Nat. Commun., 17, 1224 (2026)

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