Cancer Chemotherapy Center

Innovating safe and effective anti-cancer drugs and treatments

Brigatinib combined with anti-EGFR antibody overcomes osimertinib resistance in EGFR-mutated non-small-cell lung cancer More

To identify molecular targets and compounds for cancer therapy

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We discover and develop the novel molecular-targeted drugs by using Cancer Cell Informatics.

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Telomeres, cell immortality and cancer stemness as therapeutic targets

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We promote genome science-driven research for targeted therapy and personalized medicine

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We focus the research between clinical samples and imaging the molecular target

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Kato, Y., Kunimasa, K., Sugimoto, Y. and Tomida, A.

BCR-ABL tyrosine kinase inhibition induces metabolic vulnerability by preventing the integrated stress response in K562 cells.
Biochem. Biophys. Res. Commun., in press (2018)
Ukaji, T., Takemoto, A., Katayama, R., Takeuchi, K. and Fujita, N.

A safety study of newly generated anti-podoplanin-neutralizing antibody in cynomolgus monkey (Macaca fascicularis).
Oncotarget, 9, 33322-33336 (2018)
Nitta, N., Sugimura, T., Isozaki, A., Mikami, H., Hiraki, K., Sakuma, S., Iino, T., Arai, F., Endo, T., Fujiwaki, Y., Fukuzawa, H., Hase, M., Hayakawa, T., Hiramatsu, K., Hoshino, Y., Inaba, M., Ito, T., Karakawa, H., Kasai, Y., Koizumi, K., Lee, S., Lei, C., Li, M., Maeno, T., Matsusaka, S., Murakami, D., Nakagawa, A., Oguchi, Y., Oikawa, M., Ota, T., Shiba, K., Shintaku, H., Shirasaki, Y., Suga, K., Suzuki, Y., Suzuki, N., Tanaka, Y., Tezuka, H., Toyokawa, C., Yalikun, Y., Yamada, M., Yamagishi, M., Yamano, T., Yasumoto, A., Yatomi, Y., Yazawa, M., Di Carlo, D., Hosokawa, Y., Uemura, S., Ozeki, Y. and Goda, K.

Intelligent Image-Activated Cell Sorting.
Cell, in press (2018)
Osumi, H., Shinozaki, E., Mashima, T., Wakatsuki, T., Suenaga, M., Ichimura, T., Ogura, M., Ota, Y., Nakayama, I., Takahari, D., Chin, K., Miki, Y. and Yamaguchi, K.

Phase II Trial of Biweekly Cetuximab and Irinotecan as Third-Line Therapy for Pretreated KRAS Exon 2 Wild-Type Colorectal Cancer.
Cancer Sci., in press (2018)
Koido, M., Tani, Y., Tsukahara, S., Okamoto, Y. and Tomida, A.

InDePTH: detection of hub genes for developing gene expression networks under anticancer drug treatmen.
Oncotarget, 9, 29097-29111 (2018)