Project of the Pharmacogenomics｜Laboratories

Overview

The goal of this project is to study drug responsiveness (efficacy and toxicity) by using genome technologies and to develop effective cancer chemotherapy. The targets of our study are investigational new drugs, mainly in phase II and III clinical studies. We are aiming to establish comprehensive and reliable databases of SNPs and gene expression (cDNA microarray) by conducting each gene analysis at one center for SNP and cDNA microarray, respectively. We are further aiming to identify informative SNPs and genes for prediction of drug toxicity and sensitivity and to apply the research results in clinical settings by constructing an applied, such as small-scaled cDNA array. We are now carrying out collaborative research with multiple clinical centers to collect clinical samples quickly and efficiently and to accelerate clinical applications..

Publications

Hirono, S., Yamaue, H., Hoshikawa, Y., Ina, S., Tani, M., Kawai, M., Ushijima, M., Matsuura, M., Saiki, Y., Saiura, A., Yamamoto, J., Miki, Y., Noda, T.: Molecular markers associated with lymph node metastasis in pancreatic ductal adenocarcinoma by genome-wide expression profiling.
Cancer Sci, 101, 259-266 (2010)
Ito, Y., Nagasaki, K., Miki, Y., Iwase, T., Akiyama, F., Matsuura, M., Horii, R., Makita, M., Tokudome, N., Ushijima, M., Yoshimoto, M., Takahashi, S., Noda, T., Hatake, K.: Prospective randomized phase II study determines the clinical usefulness of genetic biomarkers for sensitivity to primary chemotherapy with paclitaxel in breast cancer.
Cancer Sci, 102, 130-136 (2010)
Dohi, Y., Ikura, T., Hoshikawa, Y., Katoh, Y., Ota, K., Nakanome, A., Muto, A., Omura, S., Ohta, T., Ito, A., Yoshida, M., Noda, T., Igarashi, K.: Bach1 inhibits oxidative stress-induced cellular senescence by impeding p53 function on chromatin.
Nat Struct Mol Biol, 15, 1246-1254 (2008)
Isomura, M., Oya, N., Tachiiri, S., Kaneyasu, Y., Nishimura, Y., Akimoto, T., Hareyama, M., Sugita, T., Mitsuhashi, N., Yamashita, T., Aoki, M., Sai, H., Hirokawa, Y., Sakata, K., Karasawa, K., Tomida, A., Tsuruo, T., Miki, Y., Noda, T., Hiraoka, M.: IL12RB2 and ABCA1 genes are associated with susceptibility to radiation dermatitis.
Clin Cancer Res, 14, 6683-6689 (2008)
Ushijima, M., Miyata, S., Eguchi, S., Kawakita, M., Yoshimoto, M., Iwase, T., Akiyama, F., Sakamoto, G., Nagasaki, K., Miki, Y., Noda, T., Hoshikawa, Y., Matsuura, M.: Common peak approach using mass spectrometry data sets for predicting the effects of anticancer drugs on breast cancer.
Cancer Inform, 3, 285-293 (2007)

Contact

Tetsuo Noda（Director）
3-8-31, Ariake, Koto-ku Tokyo 135-8550, Japan
Tel：03-3520-0111（ex 　5231）　Fax：03-3570-0443
E-mail：tnoda@jfcr.or.jp