Project of the Genome Diversity Research


The final goal of Genome Center is to apply adequate therapies with more effect and less adverse effect to each cancer patient. To achieve as to say order made cancer therapy we take the single nucleotide polymorphism (SNP) analysis approach mainly to predict the adverse effect and microarray analysis approach which can predict the response by various therapies. And also to screen the SNPs or expressed genes correspond to the phenotype from huge number of data, we are constructing an integrated cancer genome database.


  1. Prediction of adverse effect by single nucleotide polymorphism analysis
  2. Characterization of individual cancer by gene expression profile
  3. Developments and application of bioinformatical methods for cancer research and construction of integrated cancer databases for cancer research



Hirono, S., Yamaue, H., Hoshikawa, Y., Ina, S., Tani, M., Kawai, M., Ushijima, M., Matsuura, M., Saiki, Y., Saiura, A., Yamamoto, J., Miki, Y., Noda, T.
Molecular markers associated with lymph node metastasis in pancreatic ductal adenocarcinoma by genome-wide expression profiling.
Cancer Sci, 101, 259-266 (2010)
Ito, Y., Nagasaki, K., Miki, Y., Iwase, T., Akiyama, F., Matsuura, M., Horii, R., Makita, M., Tokudome, N., Ushijima, M., Yoshimoto, M., Takahashi, S., Noda, T., Hatake, K.
Prospective randomized phase II study determines the clinical usefulness of genetic biomarkers for sensitivity to primary chemotherapy with paclitaxel in breast cancer.
Cancer Sci, 102, 130-136 (2010)
Dohi, Y., Ikura, T., Hoshikawa, Y., Katoh, Y., Ota, K., Nakanome, A., Muto, A., Omura, S., Ohta, T., Ito, A., Yoshida, M., Noda, T., Igarashi, K.
Bach1 inhibits oxidative stress-induced cellular senescence by impeding p53 function on chromatin.
Nat Struct Mol Biol, 15, 1246-1254 (2008)
Isomura, M., Oya, N., Tachiiri, S., Kaneyasu, Y., Nishimura, Y., Akimoto, T., Hareyama, M., Sugita, T., Mitsuhashi, N., Yamashita, T., Aoki, M., Sai, H., Hirokawa, Y., Sakata, K., Karasawa, K., Tomida, A., Tsuruo, T., Miki, Y., Noda, T., Hiraoka, M.
IL12RB2 and ABCA1 genes are associated with susceptibility to radiation dermatitis.
Clin Cancer Res, 14, 6683-6689 (2008)
Ushijima, M., Miyata, S., Eguchi, S., Kawakita, M., Yoshimoto, M., Iwase, T., Akiyama, F., Sakamoto, G., Nagasaki, K., Miki, Y., Noda, T., Hoshikawa, Y., Matsuura, M.
Common peak approach using mass spectrometry data sets for predicting the effects of anticancer drugs on breast cancer.
Cancer Inform, 3, 285-293 (2007)


Tetsuo Noda(Director)
3-8-31, Ariake, Koto-ku Tokyo 135-8550, Japan
Tel:03-3520-0111(ex 5231) Fax:03-3570-0443


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