We are interested in the cellular heterogeneity of tumor contributing to the development of cancer and the response to chemotherapy. The focus of our research has been mouse models of human cancer. Current research remains centered on the use of the genome editing technology to investigate the pathways contributing tumor initiation and progression. We also establish a series of patient-derived organoids (PDOs) from surgical specimen. They are used to study development of human cancer as well as to examine the response to various chemotherapeutic agents. Our goal is to understand human cancer in-depth and to develop innovative treatments for cancer.
- Cellular diversity of cancer
- Development of chemotherapy
- Mechanisms of metastasis and recurrence
- Mouse models for human cancer