Researchers

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Researchers

Satoshi Takagi,Ph.D.

Affiliation

Satoshi Takagi,Ph.D.

Cancer Chemotherapy Center, Experimental Chemotherapy Staff Scientist

Contact

3-8-31 Ariake, Koto-ku, Tokyo 135-8550, Japan
Tel：+81-3-3520-0111 (ext. 5713)
Fax：+81-3-3570-0484
Mail：satoshi.takagi@jfcr.or.jp

Education & Professional Career


Area of Research

tumor microenvironment / tumor cell-platelet interactions / platelet biology / tumor metastasis / tumor invasion / tumor immunology

Membership

・Japanese Cancer Association (2004-)
・Japanese Association for Molecular Targeted Therapy of Cancer (2005-)
・Japanese Association for Metastasis Research (2010-)
・American Association for Cancer Research (2014-)
・American Society of Hematology (2014-)

Research Projects

Publications:


1.Rayes J, Retzbach E, Sheehan S, Timmerman C, Goldberg G, Miyashita T, Ishii G, Yoneda K, Tanaka F, Takemoto A, Takagi S, Fujita N, Tsutsumi M, Krishnan H, Chalise L, Natsume A, Burkett P. Podoplanin, cancer, and inflammation. J Clin Med. in press (2020)


2. Tsukamoto S, Løvendorf MB, Park J, Salem KZ, Reagan MR, Manier S, Zavidij O, Rahmat M, Huynh D, Takagi S, Kawano Y, Kokubun K, Thrue CA, Nagano K, Petri A, Roccaro AM, Capelletti M, Baron R, Kauppinen S, Ghobrial IM. Inhibition of microRNA-138 enhances bone formation in multiple myeloma bone marrow niche. Leukemia. 2018 Aug;32(8):1739-1750.


3. Kawano Y, Zavidij O, Park J, Moschetta M, Kokubun K, Mouhieddine TH, Manier S, Mishima Y, Murakami N, Bustoros M, Pistofidis RS, Reidy M, Shen YJ, Rahmat M, Lukyanchykov P, Karreci ES, Tsukamoto S, Shi J, Takagi S, Huynh D, Sacco A, Tai YT, Chesi M, Bergsagel PL, Roccaro AM, Azzi J, Ghobrial IM. Blocking IFNRA1 inhibits multiple myeloma-driven Treg expansion and immunosuppression. J Clin Invest. 2018 Jun 1;128(6):2487-2499.


4. Takagi S, Tsukamoto S, Park J, Johnson KE, Kawano Y, Moschetta M, Liu CJ, Mishima Y, Kokubun K, Manier S, Salem K, Huynh D, Sacco A, Forward JA, Roccaro A, Battinelli EM, Ghobrial IM. Platelets enhance Multiple Myeloma progression via IL-1β upregulation. Clin Cancer Res. 2018 May 15;24(10):2430-2439.


5. Schudrowitz N, Takagi S, Wessel GM, Yajima M. Germline factor DDX4 functions in blood-derived cancer cell phenotypes. Cancer Sci. 2017 Aug;108(8):1612-1619.


6. Sacco A, Kawano Y, Moschetta M, Zavidij O, Huynh D, Reagan M, Mishima Y, Manier S, Park J, Morgan E, Takagi S, Wong KK, Carrasco R, Ghobrial IM, Roccaro AM. A novel in vivo model for studying conditional dual loss of BLIMP-1 and p53 in B-cells, leading to tumor transformation. Am J Hematol. 2017 Aug;92(8):E138-E145.


7. Mishima Y, Paiva B, Shi J, Park J, Manier S, Takagi S, Massoud M, Perilla-Glen A, Aljawai Y, Huynh D, Roccaro AM, Sacco A, Capelletti M, Detappe A, Alignani D, Anderson KC, Munshi NC, Prosper F, Lohr JG, Ha G, Freeman SS, Van Allen EM, Adalsteinsson VA, Michor F, San Miguel JF, Ghobrial IM. The Mutational Landscape of Circulating Tumor Cells in Multiple Myeloma. Cell Rep. 2017 Apr 4;19(1):218-224.


8. Takeuchi S, Fukuda K, Yamada T, Arai S, Takagi S, Ishii G, Ochiai A, Iwakiri S, Itoi K, Uehara H, Nishihara H, Fujita N, Yano S. Podoplanin promotes progression of malignant pleural mesothelioma by regulating motility and focus formation. Cancer Sci. 2017 Apr;108(4):696-703.


9. Takemoto A, Okitaka M, Takagi S, Takami M, Sato S, Nishio M, Okumura S, Fujita N. A critical role of platelet TGF-β release in podoplanin-mediated tumour invasion and metastasis. Sci Rep. 2017 Feb 8;7:42186.


10. Sekiguchi T, Takemoto A, Takagi S, Takatori K, Sato S, Takami M, Fujita N. Targeting a novel domain in podoplanin for inhibiting plateletmediated tumor metastasis. Oncotarget. 2016 Jan 26;7(4):3934-46.


11. Miyata K, Takagi S, Sato S, Morioka H, Shiba K, Minamisawa T, Takami M, Fujita N. Suppression of Aggrus/podoplanin-induced platelet aggregation and pulmonary metastasis by a single-chain antibody variable region fragment. Cancer Med. 2014 Dec;3(6):1595-604.


12. Takagi S, Takemoto A, Takami M, Oh-Hara T, Fujita N.　 Platelets promote osteosarcoma cell growth through activation of the platelet-derived growth factor receptor-Akt signaling axis. Cancer Sci. 2014 Aug;105(8):983-8.


13. Takagi S, Oh-hara T, Sato S, Gong B, Takami M, Fujita N. Expression of Aggrus/podoplanin in bladder cancer and its role in pulmonary metastasis. Int J Cancer. 2014 Jun 1;134(11):2605-14.


14. Takagi S, Sato S, Oh-hara T, Takami M, Koike S, Mishima Y, Hatake K, Fujita N. Platelets promote tumor growth and metastasis via direct interaction between Aggrus/podoplanin and CLEC-2. PLoS One. 2013 Aug 21;8(8):e73609.


15. Fujita N, Takagi S. The impact of Aggrus/podoplanin on platelet aggregation and tumor metastasis. J Biochem. 2012 Nov;152(5):407-13.


16. Nakazawa Y, Takagi S, Sato S, Oh-hara T, Koike S, Takami M, Arai H, Fujita N. Prevention of hematogenous metastasis by neutralizing mice and its chimeric anti-Aggrus/podoplanin antibodies. Cancer Sci. 2011 Nov;102(11):2051-7.


17. Miyazaki I, Simizu S, Okumura H, Takagi S, Osada H. A small-molecule inhibitor shows that pirin regulates migration of melanoma cells. Nat Chem Biol. 2010 Sep;6(9):667-73.


18. Takagi S, Simizu S, Osada H. RECK negatively regulates matrix metalloproteinase-9 transcription. Cancer Res. 2009 Feb 15;69(4):1502-8.


19. Tamura Y, Simizu S, Muroi M, Takagi S, Kawatani M, Watanabe N, Osada H. Polo-like kinase 1 phosphorylates and regulates Bcl-x(L) during pironetin-induced apoptosis. Oncogene. 2009 Jan 8;28(1):107-16.


20. Simizu S, Suzuki T, Muroi M, Lai NS, Takagi S, Dohmae N, Osada H. Involvement of disulfide bond formation in the activation of heparanase. Cancer Res. 2007 Aug 15;67(16):7841-9.


21. Simizu S, Takagi S, Tamura Y, Osada H. RECK-mediated suppression of tumor cell invasion is regulated by glycosylation in human tumor cell lines. Cancer Res. 2005 Aug 15;65(16):7455-61.

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