Recent Publications

Recent Publications

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2020

Dec 28, 2020
Campisi, M., Sundararaman, S. K., Shelton, S. E., Knelson, E. H., Mahadevan, N. R., Yoshida, R., Tani, T., Ivanova, E., Cañadas, I., Osaki, T., Lee, S. W. L., Thai, T., Han, S., Piel, B. P., Gilhooley, S., Paweletz, C. P., Chiono, V., Kamm, R. D., Kitajima, S. and Barbie, D. A.
Tumor-derived cGAMP regulates activation of the vasculature.
Front. Immunol., 11, 2090 (2020)
Dec 28, 2020
Kitajima, S., Li, F. and Takahashi, C.
Tumor milieu controlled by RB tumor suppressor.
Int. J. Mol. Sci., 21, 2450 (2020)
Dec 28, 2020
Sehgal, K., Portell, A. J., Ivanova, E. V., Lizotte, P. H., Mahadevan, N. R., Greene, J. R., Vajdi, A., Gurjao, C., Teceno, T., Taus, L. J., Thai, T. C., Kitajima, S., Liu, D., Tani, T., Noureddine, M., Lau, C. J., Kirschmeier, P. T., Liu, D., Giannakis, M., Jenkins, R. W., Gokhale, P. C., Goldoni, S., Pinzon-Ortiz, M., Hastings, W. D., Hammerman, P., Miret, J. J., Paweletz, C. P. and Barbie, D. A.
Dynamic single-cell RNA sequencing identifies immunotherapy persister cells following PD-1 blockade.
J. Clin. Invest., in press (2020)
Dec 21, 2020
Osumi, H., Muroi, A., Sakahara, M., Kawachi, H., Okamoto, T., Natsume, Y., Yamanaka, H., Takano, H., Kusama, D., Shinozaki, E., Ooki, A., Yamaguchi, K., Ueno, M., Takeuchi, K., Noda, T., Nagayama, S., Koshikawa, N. and Yao, R.
Evaluation of the RAS signaling network in response to MEK inhibition using organoids derived from a familial adenomatous polyposis patient.
Sci. Rep., 10, 17455 (2020)
Dec 07, 2020
Gotoh, O., Kiyotani, K., Chiba, T., Sugiyama, Y., Takazawa, Y., Nemoto, K., Kato, K., Tanaka, N., Nomura, H., Hasegawa, K., Fujiwara, K., Takamatsu, S., Matsumura, N., Noda, T. and Mori, S.
Immunogenomic Landscape of Gynecologic Carcinosarcoma.
Gynecol. Oncol., in press (2020)
Dec 03, 2020
Furuta, H., Araki, M., Masago, K., Sagae, Y., Fujita, S., Seto, K., Shimizu, J., Horio, Y., Sasaki, E., Hosoda, W., Katayama, R., Okuno, Y. and Hida, T.
Novel resistance mechanisms including L1196Q, P1094H, and R1248_D1249insertion in three patients with non-small-cell lung cancer following ALK tyrosine kinase inhibitor treatment.
J. Thorac. Oncol., in press (2020)
Dec 03, 2020
Ariyasu, R., Yanagitani, N., Tadokoro, K., Yamaguchi, T., Uchibori, K., Kitazono, S., Fujita, N., Katayama, R. and Nishio, M.
Efficacy of EGFR tyrosine kinase inhibitors in patients having EGFR-activating mutations with or without BIM polymorphisms.
Cancer Chemother. Pharmacol., 86, 517-525 (2020)
Oct 12, 2020
Kato, Y., Kunimasa, K., Takahashi, M., Harada, A., Nagasawa, I., Osawa, M., Sugimoto, Y. and Tomida, A.
GZD824 inhibits GCN2 and sensitizes cancer cells to amino acid starvation stress.
Molecular Pharmacology, in press (2020)
Oct 06, 2020
Nosol, K., Romane, K., Irobalieva, R. N., Alam, A., Kowal, J., Fujita, N. and Locher, K. P.
Cryo-EM structures reveal distinct mechanisms of inhibition of the human multidrug transporter ABCB1.
Proc. Natl. Acad. Sci. U. S. A., in press (2020)
Oct 05, 2020
Sonoda, T., Yanagitani, N., Suga, K., Yoshizawa, T., Nishikawa, S., Kitazono, S., Horiike, A., Shiba, K., Ishizuka, T., Nishio, M. and Matsusaka, S.
A novel system to detect circulating tumor cells using two different size-selective microfilters.
Anticancer Res., 40, 5577-5582 (2020)
Sep 03, 2020
Akiyoshi, T., Gotoh, O., Tanaka, N., Kiyotani, K., Yamamoto, N., Ueno, M., Fukunaga, Y. and Mori, S.
T-cell complexity and density are associated with sensitivity to neoadjuvant chemoradiotherapy in patients with rectal cancer.
Cancer Immunol. Immunother., in press (2020)
Jul 22, 2020
Nozawa, R. S., Yamamoto, T., Takahashi, M., Tachiwana, H., Maruyama, R., Hirota, T. and Saitoh, N.
Nuclear microenvironment in cancer: control through liquid-liquid phase separation.
Cancer Sci., in press (2020)
Jul 13, 2020
Nitta, N., Iino, T., Isozaki, A., Yamagishi, M., Kitahama, Y., Sakuma, S., Suzuki, Y., Tezuka, H., Oikawa, M., Arai, F., Asai, T., Deng, D., Fukuzawa, H., Hase, M., Hasunuma, T., Hayakawa, T., Hirai, K., Hiramatsu, K., Hoshino, Y., Inaba, M., Inoue, Y., Ito, T., Karakawa, H., Kasai, Y., Kato, Y., Kobayashi, H., Lei, C., Matsusaka, S., Mikami, H., Nakagawa, A., Numata, k., Ota, T., Sekiya, T., Shiba, K., Shirasaki, Y., Suzuki, N., Tanaka, S., Ueno, S., Watarai, H., Yamano, T., Yazawa, M., Yonamine, Y., Carlo, D. D., Hosokawa, Y., Uemura, S., Sugimura, T., Ozeki, Y. and Goda, K.
Raman image-activated cell sorting.
Naure Communications, 11, 3452 (2020)
Jun 29, 2020
Papadopoulos, K. P., Borazanci, E., Shaw, A. T., katayama, R., Shimizu, Y., Zhu, V. W., sun, T. Y., Wakelee, H. A., Madison, R., Schrock, A. B., Senaldi, G., Nakao, N., Hanzawa, H., Tachibana, M., Isoyama, T., Nakamaru, K., Deng, C., Li, M., Fran, F., Zhao, O., Gao, Y., Seto, T., Janne, P. A. and Ou, S. H. I.
US phase 1 first-in-human study of taletrectinib (DS-6051b/AB-106), a ROS1/TRK inhibitor, in patients with advanced solid tumors.
Clin. Cancer Res., in press (2020)
Jun 26, 2020
Arai, S., Takeuchi, S., Fukuda, K., Taniguchi, H., Nishiyama, A., Tanimoto, A., Satouchi, M., Yamashita, K., Ohtsubo, K., Nanjo, S., Kumagai, T., Katayama, R., Nishio, M., Zheng, M. M., Wu, Y. L., Nishihara, H., Yamamoto, T., Nakada, M. and Yano, S.
Osimertinib overcomes alectinib resistance caused by amphiregulin in a leptomeningeal carcinomatosis model of ALK-rearranged lung cancer.
J. Thorac. Oncol., 15, 752-765 (2020)
Jun 26, 2020
Ono, F., Chiba, S., Isaka, Y., Matsumoto, S., Ma, B., Katayama, R., Araki, M. and Okuno, Y.
Improvement in predicting drug sensitivity changes associated with protein mutations using a molecular dynamics based alchemical mutation method.
Sci. Rep., 10, 2161 (2020)
Jun 26, 2020
Yanagitani, N., Uchibori, K., Koike, S., Tsukahara, M., Kitazono, S., Yoshizawa, T., Horiike, A., Ohyanagi, F., Tambo, Y., Nishikawa, S., Fujita, N., Katayama, R. and Nishio, M.
Drug resistance mechanisms in Japanese ALK positive NSCLC and the clinical responses based on the resistant mechanisms.
Cancer Sci., 111, 932-939 (2020)
Jun 22, 2020
Fujimura, A., Hayashi, Y., Kato, K., Kogure, Y., Kameyama, M., Shimamoto, H., Daitoku, H., Fukamizu, A., Hirota, T. and Kimura, K.
Identification of a novel nucleolar protein complex required for mitotic chromosome segregation through centromeric accumulation of Aurora B.
Nucleic Acids Res., in press (2020)
Jun 15, 2020
Kaneyasu, T., Mori, S., Yamauchi, H., Ohsumi, S., Ohno, S., Aoki, D., Baba, S., Kawano, J., Miki, Y., Matsumoto, N., Nagasaki, M., Yoshida, R., Akashi-Tanaka, S., Iwase, T., Kitagawa, D., Masuda, K., hirasawa, A., Arai, M., Takei, J., Ide, Y., Gotoh, O., Yaguchi, N., Nishi, M., Kaneko, K., Matsuyama, Y., Okawa, M., Suzuki, M., Nezu, A., Yokoyama, S., Amino, S., Inuzuka, M., Noda, T. and Nakamura, S.
Prevalence of disease-causing genes in Japanese patients with BRCA1/2-wildtype hereditary breast and ovarian cancer syndrome.
NPJ Breast Cancer, in press (2020)
Jun 02, 2020
Oka, M., Kobayashi, N., Matsumura, K., Nishio, M., Nakano, K., Okamura, T., Okochi, H., Minamisawa, T., Shiba, K. and Saeki, K.
New role for growth/differentiation factor 15 in the survival of transplanted brown adipose tissues in cooperation with interleukin-6.
Cells, in press (2020)
May 26, 2020
Misawa, T., Tanaka, Y., Okada, R. and Takahashi, A.
Biology of extracellular vesicles secreted from senescent cells as senescence-associated secretory phenotype factors.
Geriatr. Gerontol. Int., in press (2020)
May 26, 2020
Sakamoto, K. and Takeuchi, K.
Cytogenetics of blastic plasmacytoid dendritic cell neoplasm: Chromosomal rearrangements and DNA copy-number alterations.
Hematology/oncology clinics of North America, 34, 523-538 (2020)
May 26, 2020
Osako, T., Lee, H., Turashvili, G., Chiu, D. Y., McKinney, S., Joosten, S. E. P., Wilkinson, D. S., Nielsen, T. O., Zwart, W., Emerman, J. T., Eaves, C. J., Caldas, C. and Aparicio, S.
Age-correlated protein and transcript expression in breast cancer and normal breast tissues is dominated by host endocrine effects.
Nature Cancer, in press (2020)
May 26, 2020
Hitomi, K., Okada, R., Loo, T. M., Miyata, K., Nakamura, A. J. and Takahashi, A.
DNA damage regulates senescence-associated extracellular vesicle release via the ceramide pathway to prevent excessive inflammatory responses.
Int. J. Mol. Sci., 21, 3720 (2020)
May 08, 2020
Tachiwana, H., Yamamoto, T. and Saitoh, N.
Gene regulation by non-coding RNAs in the 3D genome architecture.
Current Opinion in Genetics & Development, 61, 69-74 (2020)
May 08, 2020
Wakita, M., Takahashi, A., Sano, O., Loo, T. M., Imai, Y., Narukawa, M., Iwata, H., Matsudaira, T., Kawamoto, S., Ohtani, N., Yoshimori, T. and Hara, E.
A BET family protein degrader provokes senolysis by targeting NHEJ and autophagy in senescent cells.
Nat. Commun., 11, 1935 (2020)
Apr 02, 2020
Nagasawa, I., Koido, M., Tani, Y., Tsukahara, S., Kunimasa, K. and Tomida, A.
Disrupting ATF4 expression mechanisms provides an effective strategy for BRAF-targeted melanoma therapy.
iScience, in press (2020)
Mar 03, 2020
Okamoto, Y., Saito, T., Tani, Y., Toki, T., Hasebe, A., Koido, M. and Tomida, A.
The kinase PERK represses translation of the G protein-coupled receptor LGR5 and receptor tyrosine kinase ERBB3 during ER stress in cancer cells.
J. Biol. Chem., in press (2020)
Feb 12, 2020
Miyazaki, K., Ichikawa, Y., Saitoh, N. and Saitoh, H.
Three types of nuclear envelope assemblies associated with micronuclei.
CellBio, in press (2020)
Feb 07, 2020
Loo, T. M., Miyata, K., Tanaka, Y. and Takahashi, A.
Cellular senescence and senescence-associated secretory phenotype via the cGAS-STING signaling pathway in cancer.
Cancer Sci., 111, 304-311 (2020)
Feb 03, 2020
Tanaka, M., Homme, M., Yamazaki, Y., Ae, K., Matsumoto, S., Subramanian, S. and Nakamura, T.
Cooperation between SS18-SSX1 and miR-214 in synovial sarcoma development and progression.
Cancers, 12, 324 (2020)
Jan 21, 2020
Kawakami, R., Mashima, T., Kawata, N., Kumagai, K., Migita, T., Sano, T., Mizunuma, N., Yamaguchi, K. and Seimiya, H.
ALDH1A3‐mTOR axis as a therapeutic target for anticancer drug‐tolerant persister cells in gastric cancer.
Cancer Sci., in press (2020)
Jan 21, 2020
Takahashi, K., Seto, Y., Okada, K., Uematsu, S., Uchibori, K., Tsukahara, M., Oh-hara, T., Fujita, N., Yanagitani, N., Nishio, M., Okubo, K. and Katayama, R.
Overcoming resistance by ALK compound mutation (I1171S + G1269A) after sequential treatment of multiple ALK inhibitors in non-small cell lung cancer.
Thorac. Cancer, in press (2020)
Jan 07, 2020
Jang, M. K., Mashima, T. and Seimiya, H.
Tankyrase inhibitors target colorectal cancer stem cells via AXIN-dependent downregulation of c-KIT tyrosine kinase.
Mol. Cancer Ther., in press (2020)
Jan 06, 2020
Tanaka, N., Takahara, A., Hagio, T., Nishiko, R., Kanayama, J., Gotoh, O. and Mori, S.
Sequencing artifacts derived from a library preparation method using enzymatic fragmentation.
PLoS One, 15, e0227427 (2020)

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