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Dec 28, 2020
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Campisi, M., Sundararaman, S. K., Shelton, S. E., Knelson, E. H., Mahadevan, N. R., Yoshida, R., Tani, T., Ivanova, E., Cañadas, I., Osaki, T., Lee, S. W. L., Thai, T., Han, S., Piel, B. P., Gilhooley, S., Paweletz, C. P., Chiono, V., Kamm, R. D., Kitajima, S. and Barbie, D. A. Tumor-derived cGAMP regulates activation of the vasculature.
Front. Immunol., 11, 2090 (2020)
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Dec 28, 2020
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Kitajima, S., Li, F. and Takahashi, C. Tumor milieu controlled by RB tumor suppressor.
Int. J. Mol. Sci., 21, 2450 (2020)
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Dec 28, 2020
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Sehgal, K., Portell, A. J., Ivanova, E. V., Lizotte, P. H., Mahadevan, N. R., Greene, J. R., Vajdi, A., Gurjao, C., Teceno, T., Taus, L. J., Thai, T. C., Kitajima, S., Liu, D., Tani, T., Noureddine, M., Lau, C. J., Kirschmeier, P. T., Liu, D., Giannakis, M., Jenkins, R. W., Gokhale, P. C., Goldoni, S., Pinzon-Ortiz, M., Hastings, W. D., Hammerman, P., Miret, J. J., Paweletz, C. P. and Barbie, D. A. Dynamic single-cell RNA sequencing identifies immunotherapy persister cells following PD-1 blockade.
J. Clin. Invest., in press (2020)
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Dec 21, 2020
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Osumi, H., Muroi, A., Sakahara, M., Kawachi, H., Okamoto, T., Natsume, Y., Yamanaka, H., Takano, H., Kusama, D., Shinozaki, E., Ooki, A., Yamaguchi, K., Ueno, M., Takeuchi, K., Noda, T., Nagayama, S., Koshikawa, N. and Yao, R. Evaluation of the RAS signaling network in response to MEK inhibition using organoids derived from a familial adenomatous polyposis patient.
Sci. Rep., 10, 17455 (2020)
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Dec 07, 2020
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Gotoh, O., Kiyotani, K., Chiba, T., Sugiyama, Y., Takazawa, Y., Nemoto, K., Kato, K., Tanaka, N., Nomura, H., Hasegawa, K., Fujiwara, K., Takamatsu, S., Matsumura, N., Noda, T. and Mori, S. Immunogenomic Landscape of Gynecologic Carcinosarcoma.
Gynecol. Oncol., in press (2020)
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Dec 03, 2020
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Furuta, H., Araki, M., Masago, K., Sagae, Y., Fujita, S., Seto, K., Shimizu, J., Horio, Y., Sasaki, E., Hosoda, W., Katayama, R., Okuno, Y. and Hida, T. Novel resistance mechanisms including L1196Q, P1094H, and R1248_D1249insertion in three patients with non-small-cell lung cancer following ALK tyrosine kinase inhibitor treatment.
J. Thorac. Oncol., in press (2020)
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Dec 03, 2020
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Ariyasu, R., Yanagitani, N., Tadokoro, K., Yamaguchi, T., Uchibori, K., Kitazono, S., Fujita, N., Katayama, R. and Nishio, M. Efficacy of EGFR tyrosine kinase inhibitors in patients having EGFR-activating mutations with or without BIM polymorphisms.
Cancer Chemother. Pharmacol., 86, 517-525 (2020)
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Oct 12, 2020
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Kato, Y., Kunimasa, K., Takahashi, M., Harada, A., Nagasawa, I., Osawa, M., Sugimoto, Y. and Tomida, A. GZD824 inhibits GCN2 and sensitizes cancer cells to amino acid starvation stress.
Molecular Pharmacology, in press (2020)
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Oct 06, 2020
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Nosol, K., Romane, K., Irobalieva, R. N., Alam, A., Kowal, J., Fujita, N. and Locher, K. P. Cryo-EM structures reveal distinct mechanisms of inhibition of the human multidrug transporter ABCB1.
Proc. Natl. Acad. Sci. U. S. A., in press (2020)
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Oct 05, 2020
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Sonoda, T., Yanagitani, N., Suga, K., Yoshizawa, T., Nishikawa, S., Kitazono, S., Horiike, A., Shiba, K., Ishizuka, T., Nishio, M. and Matsusaka, S. A novel system to detect circulating tumor cells using two different size-selective microfilters.
Anticancer Res., 40, 5577-5582 (2020)
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Sep 03, 2020
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Akiyoshi, T., Gotoh, O., Tanaka, N., Kiyotani, K., Yamamoto, N., Ueno, M., Fukunaga, Y. and Mori, S. T-cell complexity and density are associated with sensitivity to neoadjuvant chemoradiotherapy in patients with rectal cancer.
Cancer Immunol. Immunother., in press (2020)
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Jul 22, 2020
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Nozawa, R. S., Yamamoto, T., Takahashi, M., Tachiwana, H., Maruyama, R., Hirota, T. and Saitoh, N. Nuclear microenvironment in cancer: control through liquid-liquid phase separation.
Cancer Sci., in press (2020)
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Jul 13, 2020
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Nitta, N., Iino, T., Isozaki, A., Yamagishi, M., Kitahama, Y., Sakuma, S., Suzuki, Y., Tezuka, H., Oikawa, M., Arai, F., Asai, T., Deng, D., Fukuzawa, H., Hase, M., Hasunuma, T., Hayakawa, T., Hirai, K., Hiramatsu, K., Hoshino, Y., Inaba, M., Inoue, Y., Ito, T., Karakawa, H., Kasai, Y., Kato, Y., Kobayashi, H., Lei, C., Matsusaka, S., Mikami, H., Nakagawa, A., Numata, k., Ota, T., Sekiya, T., Shiba, K., Shirasaki, Y., Suzuki, N., Tanaka, S., Ueno, S., Watarai, H., Yamano, T., Yazawa, M., Yonamine, Y., Carlo, D. D., Hosokawa, Y., Uemura, S., Sugimura, T., Ozeki, Y. and Goda, K. Raman image-activated cell sorting.
Naure Communications, 11, 3452 (2020)
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Jun 29, 2020
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Papadopoulos, K. P., Borazanci, E., Shaw, A. T., katayama, R., Shimizu, Y., Zhu, V. W., sun, T. Y., Wakelee, H. A., Madison, R., Schrock, A. B., Senaldi, G., Nakao, N., Hanzawa, H., Tachibana, M., Isoyama, T., Nakamaru, K., Deng, C., Li, M., Fran, F., Zhao, O., Gao, Y., Seto, T., Janne, P. A. and Ou, S. H. I. US phase 1 first-in-human study of taletrectinib (DS-6051b/AB-106), a ROS1/TRK inhibitor, in patients with advanced solid tumors.
Clin. Cancer Res., in press (2020)
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Jun 26, 2020
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Arai, S., Takeuchi, S., Fukuda, K., Taniguchi, H., Nishiyama, A., Tanimoto, A., Satouchi, M., Yamashita, K., Ohtsubo, K., Nanjo, S., Kumagai, T., Katayama, R., Nishio, M., Zheng, M. M., Wu, Y. L., Nishihara, H., Yamamoto, T., Nakada, M. and Yano, S. Osimertinib overcomes alectinib resistance caused by amphiregulin in a leptomeningeal carcinomatosis model of ALK-rearranged lung cancer.
J. Thorac. Oncol., 15, 752-765 (2020)
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Jun 26, 2020
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Ono, F., Chiba, S., Isaka, Y., Matsumoto, S., Ma, B., Katayama, R., Araki, M. and Okuno, Y. Improvement in predicting drug sensitivity changes associated with protein mutations using a molecular dynamics based alchemical mutation method.
Sci. Rep., 10, 2161 (2020)
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Jun 26, 2020
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Yanagitani, N., Uchibori, K., Koike, S., Tsukahara, M., Kitazono, S., Yoshizawa, T., Horiike, A., Ohyanagi, F., Tambo, Y., Nishikawa, S., Fujita, N., Katayama, R. and Nishio, M. Drug resistance mechanisms in Japanese ALK positive NSCLC and the clinical responses based on the resistant mechanisms.
Cancer Sci., 111, 932-939 (2020)
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Jun 22, 2020
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Fujimura, A., Hayashi, Y., Kato, K., Kogure, Y., Kameyama, M., Shimamoto, H., Daitoku, H., Fukamizu, A., Hirota, T. and Kimura, K. Identification of a novel nucleolar protein complex required for mitotic chromosome segregation through centromeric accumulation of Aurora B.
Nucleic Acids Res., in press (2020)
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Jun 15, 2020
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Kaneyasu, T., Mori, S., Yamauchi, H., Ohsumi, S., Ohno, S., Aoki, D., Baba, S., Kawano, J., Miki, Y., Matsumoto, N., Nagasaki, M., Yoshida, R., Akashi-Tanaka, S., Iwase, T., Kitagawa, D., Masuda, K., hirasawa, A., Arai, M., Takei, J., Ide, Y., Gotoh, O., Yaguchi, N., Nishi, M., Kaneko, K., Matsuyama, Y., Okawa, M., Suzuki, M., Nezu, A., Yokoyama, S., Amino, S., Inuzuka, M., Noda, T. and Nakamura, S. Prevalence of disease-causing genes in Japanese patients with BRCA1/2-wildtype hereditary breast and ovarian cancer syndrome.
NPJ Breast Cancer, in press (2020)
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Jun 02, 2020
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Oka, M., Kobayashi, N., Matsumura, K., Nishio, M., Nakano, K., Okamura, T., Okochi, H., Minamisawa, T., Shiba, K. and Saeki, K. New role for growth/differentiation factor 15 in the survival of transplanted brown adipose tissues in cooperation with interleukin-6.
Cells, in press (2020)
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May 26, 2020
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Misawa, T., Tanaka, Y., Okada, R. and Takahashi, A. Biology of extracellular vesicles secreted from senescent cells as senescence-associated secretory phenotype factors.
Geriatr. Gerontol. Int., in press (2020)
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May 26, 2020
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Sakamoto, K. and Takeuchi, K. Cytogenetics of blastic plasmacytoid dendritic cell neoplasm: Chromosomal rearrangements and DNA copy-number alterations.
Hematology/oncology clinics of North America, 34, 523-538 (2020)
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May 26, 2020
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Osako, T., Lee, H., Turashvili, G., Chiu, D. Y., McKinney, S., Joosten, S. E. P., Wilkinson, D. S., Nielsen, T. O., Zwart, W., Emerman, J. T., Eaves, C. J., Caldas, C. and Aparicio, S. Age-correlated protein and transcript expression in breast cancer and normal breast tissues is dominated by host endocrine effects.
Nature Cancer, in press (2020)
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May 26, 2020
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Hitomi, K., Okada, R., Loo, T. M., Miyata, K., Nakamura, A. J. and Takahashi, A. DNA damage regulates senescence-associated extracellular vesicle release via the ceramide pathway to prevent excessive inflammatory responses.
Int. J. Mol. Sci., 21, 3720 (2020)
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May 08, 2020
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Tachiwana, H., Yamamoto, T. and Saitoh, N. Gene regulation by non-coding RNAs in the 3D genome architecture.
Current Opinion in Genetics & Development, 61, 69-74 (2020)
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May 08, 2020
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Wakita, M., Takahashi, A., Sano, O., Loo, T. M., Imai, Y., Narukawa, M., Iwata, H., Matsudaira, T., Kawamoto, S., Ohtani, N., Yoshimori, T. and Hara, E. A BET family protein degrader provokes senolysis by targeting NHEJ and autophagy in senescent cells.
Nat. Commun., 11, 1935 (2020)
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Apr 02, 2020
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Nagasawa, I., Koido, M., Tani, Y., Tsukahara, S., Kunimasa, K. and Tomida, A. Disrupting ATF4 expression mechanisms provides an effective strategy for BRAF-targeted melanoma therapy.
iScience, in press (2020)
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Mar 03, 2020
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Okamoto, Y., Saito, T., Tani, Y., Toki, T., Hasebe, A., Koido, M. and Tomida, A. The kinase PERK represses translation of the G protein-coupled receptor LGR5 and receptor tyrosine kinase ERBB3 during ER stress in cancer cells.
J. Biol. Chem., in press (2020)
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Feb 12, 2020
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Miyazaki, K., Ichikawa, Y., Saitoh, N. and Saitoh, H. Three types of nuclear envelope assemblies associated with micronuclei.
CellBio, in press (2020)
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Feb 07, 2020
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Loo, T. M., Miyata, K., Tanaka, Y. and Takahashi, A. Cellular senescence and senescence-associated secretory phenotype via the cGAS-STING signaling pathway in cancer.
Cancer Sci., 111, 304-311 (2020)
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Feb 03, 2020
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Tanaka, M., Homme, M., Yamazaki, Y., Ae, K., Matsumoto, S., Subramanian, S. and Nakamura, T. Cooperation between SS18-SSX1 and miR-214 in synovial sarcoma development and progression.
Cancers, 12, 324 (2020)
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Jan 21, 2020
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Kawakami, R., Mashima, T., Kawata, N., Kumagai, K., Migita, T., Sano, T., Mizunuma, N., Yamaguchi, K. and Seimiya, H. ALDH1A3‐mTOR axis as a therapeutic target for anticancer drug‐tolerant persister cells in gastric cancer.
Cancer Sci., in press (2020)
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Jan 21, 2020
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Takahashi, K., Seto, Y., Okada, K., Uematsu, S., Uchibori, K., Tsukahara, M., Oh-hara, T., Fujita, N., Yanagitani, N., Nishio, M., Okubo, K. and Katayama, R. Overcoming resistance by ALK compound mutation (I1171S + G1269A) after sequential treatment of multiple ALK inhibitors in non-small cell lung cancer.
Thorac. Cancer, in press (2020)
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Jan 07, 2020
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Jang, M. K., Mashima, T. and Seimiya, H. Tankyrase inhibitors target colorectal cancer stem cells via AXIN-dependent downregulation of c-KIT tyrosine kinase.
Mol. Cancer Ther., in press (2020)
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Jan 06, 2020
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Tanaka, N., Takahara, A., Hagio, T., Nishiko, R., Kanayama, J., Gotoh, O. and Mori, S. Sequencing artifacts derived from a library preparation method using enzymatic fragmentation.
PLoS One, 15, e0227427 (2020)
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