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- Ewing's sarcoma precursors are highly enriched in embryonic ...
Update : 2015/5/14
Ewing's sarcoma precursors are highly enriched in embryonic osteochondrogenic progenitors
- Tanaka, M., Yamazaki, Y., Kanno, Y., Igarashi, K., Aisaki, K., Kanno, J., Nakamura, T.
- J. Clin, Invest., 124:3061-3074 (2014) Link
Ewing's sarcoma is a rare pediatric bone tumor that results from a genetic translocation that results in an EWS-ETS fusion. The tumor can have both mesodermal and ectodermal features, making it difficult to determine the cellular origin. In this issue, Miwa Tanaka and colleagues developed a murine model of Ewing's sarcoma by introducing EWS-ETS fusion genes into a late gestational cell fraction enriched for osteochondrogenic progenitors from the embryonic superficial zone (eSZ) of the long bones. The model tumors shared a gene expression profile with human Ewing's sarcoma, and both murine and human tumors exhibited upregulated WNT/β-catenin and EGF signaling. Finally, inhibitors of the WNT/β-catenin pathway attenuated murine tumor growth.
