Takashi Yokoyama, Ph.D.

Affiliation

Cancer Institute, Carcinogenesis Postdoctoral Scientist

Contact

3-8-31 Ariake, Koto-ku, Tokyo 135-8550, Japan.
Tel：+81-3-3520-1111 (5394)
Fax：+81-3-3570-0463
Mail：takashi.yokoyama@jfcr.or.jp

Education & Professional Career

Attending Associate, April 2008 to present
Division of Carcinogenesis, The Cancer Institute, Japanese Foundation for Cancer Research.
Reserch Assistant April 2007 to March 2008
Department of Biology, Graduate School of Science, Chiba University
Ph. D. in Department of Biology, Graduate School of Science, Chiba University, March 2007.

Area of Research

・Leukemogenesis
・Carcinogenesis
・Cell signaling

Membership

・Japanese Cancer Association
・The Japanese Society of Pathology

Research Projects

We research about mechanism of Trib1 in leukemogenesis and involvement in human leukemia case. We have identified that Trib1 induces acute myeloid leukemia through activation of Ras–MAP kinase pathway by interaction with MEK1 and degradation of C/EBPa regulating myeloid differentiation in murine bone marrow transfer model. Recently, we identified active mutation of TRIB1 in a human case of Down syndrome-related acute megakaryocytic leukemia. These results indicate that TRIB1 is important oncogene for leukemogenesis, It aims toapplication to the diagnosis and therapy for leukemia.