第34回先端研究セミナーのお知らせ

演題：Understanding unconventional kinetochores

演者：秋吉　文悟 博士 (University of Oxford, Department of Biochemistry)

抄録：

The kinetochore is the macromolecular protein complex that drives chromosome segregation in eukaryotes. It has been widely assumed that the core kinetochore consists of proteins that are common to all eukaryotes. However, no conventional kinetochore components have been identified in any kinetoplastid genome, thus challenging this assumption of universality. We recently identified 19 kinetochore proteins in Trypanosoma brucei, an experimentally-tractable kinetoplastid parasite. The majority are conserved among kinetoplastids, but none of them has detectable homology to conventional kinetochore proteins. These proteins instead have a variety of features not found in conventional kinetochore proteins, suggesting that kinetoplastids build kinetochores using a distinct set of proteins. We are currently characterizing these 19 kinetochore proteins in vitro and in vivo to understand how they carry out essential kinetochore functions.

日時：　２０１５年７月３１日（金）　１１：００〜１２：００

場所：研究所　１階セミナー室B

連絡先：広田亨　（内線5251）

＊外部の研究者のご来聴を歓迎いたします。尚、本セミナーの内容は専門的であり、 医学・生物分野の研究に携わる方を対象としております。