がん研セミナーのお知らせ (5月30日)

演題：β-catenin in the melanocyte lineage

演者：Lionel Larue  博士 (Institut Curie, Paris, France)

抄録：The incidence of cutaneous melanoma is increasing regularly in France and western countries. The rate of mortality remains high despite the availability of innovative therapies on the market. The failure of these new therapies is due in part to insufficient basic knowledge, inappropriate cell systems and in vivo melanoma models. Malignant melanoma is an aggressive human tumour and both genetics and epigenetics events contribute to regulate its initiation and progression. The laboratory aims to improve understanding, in an integrative manner, of the molecular and cellular mechanisms associated with the normal and pathological development of melanocytes and melanoma. Consequently, we generate crucial information to the understanding of the establishment of melanocytes from melanoblasts during development and the renewal of melanocytes from melanocyte stem cells. We decipher, in vitro and in vivo, various signalling pathways, including MAPK, PI3K and WNT. In this talk, we will focus on the function of b-catenin (CTNNB1) during melanomagenesis

日時：2016年　5月 30日（水）11:00〜12:00

場所：吉田講堂

連絡先：中村卓郎（内線5391）

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医学・生物分野の研究に携わる方を対象としております。