部門紹介

研究業績

目次

  1. 原著論文
  2. 総説・解説や教科書など

原著論文

2010年

Ito, Y., Nagasaki, K., Miki, Y., Iwase, T., Akiyama, F., Matsuura, M., Horii, R., Makita, M., Tokudome, N., Ushijima, M., Yoshimoto, M., Takahashi, S., Noda, T., Hatake, K.
Prospective randomized phase II study determines the clinical usefulness of genetic biomarkers for sensitivity to primary chemotherapy with paclitaxel in breast cancer.
Cancer Sci, 102, 130-136 (2010)

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2009年

Niwa, T., Saito, H., Imajoh-ohmi, S., Kaminishi, M., Seto, Y., Miki, Y., Nakanishi, A.
BRCA2 interacts with the cytoskeletal linker protein plectin to form a complex controlling centrosome localization.
Cancer Sci, 100, 2115-2125 (2009)

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2008年

Hirai, Y., Banno, K., Suzuki, M., Ichikawa, Y., Udagawa, Y., Sugano, K., Miki, Y.
Molecular epidemiological and mutational analysis of DNA mismatch repair (MMR) genes in endometrial cancer patients with HNPCC-associated familial predisposition to cancer.
Cancer Sci, 99, 1715-1719 (2008)
Izawa, N., Matsumoto, S., Manabe, J., Tanizawa, T., Hoshi, M., Shigemitsu, T., Machinami, R., Kanda, H., Takeuchi, K., Miki, Y., Arai, M., Shirahama, S., Kawaguchi, N.
A Japanese patient with Li-Fraumeni syndrome who had nine primary malignancies associated with a germline mutation of the p53 tumor-suppressor gene.
Int J Clin Oncol, 13, 78-82 (2008)
Shinagawa, H., Miki, Y., Yoshida, K.
BRCA1-mediated ubiquitination inhibits topoisomerase II alpha activity in response to oxidative stress.
Antioxid Redox Signal, 10, 939-949 (2008)
Sugano, K., Nakamura, S., Ando, J., Takayama, S., Kamata, H., Sekiguchi, I., Ubukata, M., Kodama, T., Arai, M., Kasumi, F., Hirai, Y., Ikeda, T., Jinno, H., Kitajima, M., Aoki, D., Hirasawa, A., Takeda, Y., Yazaki, K., Fukutomi, T., Kinoshita, T., Tsunematsu, R., Yoshida, T., Izumi, M., Umezawa, S., Yagata, H., Komatsu, H., Arimori, N., Matoba, N., Gondo, N., Yokoyama, S., Miki, Y.
Cross-sectional analysis of germline BRCA1 and BRCA2 mutations in Japanese patients suspected to have hereditary breast/ovarian cancer.
Cancer Sci, 99, 1967-1976 (2008)
Tanaka, S., Arii, S., Yasen, M., Mogushi, K., Su, N.T., Zhao, C., Imoto, I., Eishi, Y., Inazawa, J., Miki, Y., Tanaka, H.
Aurora kinase B is a predictive factor for the aggressive recurrence of hepatocellular carcinoma after curative hepatectomy.
Br J Surg, 95, 611-619 (2008)
Tomiyoshi, G., Nakanishi, A., Takenaka, K., Yoshida, K., Miki, Y.
Novel BRCA2-interacting protein BJ-HCC-20A inhibits the induction of apoptosis in response to DNA damage.
Cancer Sci, 99, 747-754 (2008)

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2007年

Fujisawa, H., Isomura, M., Eguchi, S., Ushijima, M., Miyata, S., Miki, Y., Matsuura, M.
Identifying haplotype block structure using an ancestor-derived model.
J Hum Genet, 52, 738-746 (2007)
Han, X., Saito, H., Miki, Y., Nakanishi, A.
A CRM1-mediated nuclear export signal governs cytoplasmic localization of BRCA2 and is essential for centrosomal localization of BRCA2.
Oncogene, (2007)
Horii, R., Akiyama, F., Ito, Y., Matsuura, M., Miki, Y., Iwase, T.
Histological features of breast cancer, highly sensitive to chemotherapy.
Breast Cancer, 14, 393-400 (2007)
Liu, H., Lu, Z.G., Miki, Y., Yoshida, K.
Protein kinase C δ induces transcription of the TP53 tumor suppressor gene by controlling death-promoting factor Btf in the apoptotic response to DNA damage.
Mol Cell Biol, 27, 8480-8491 (2007)
Maekawa, T., Shinagawa, T., Sano, Y., Sakuma, T., Nomura, S., Nagasaki, K., Miki, Y., Saito-Ohara, F., Inazawa, J., Kohno, T., Yokota, J., Ishii, S.
Reduced levels of ATF-2 predispose mice to mammary tumors.
Mol Cell Biol, 27, 1730-1744 (2007)
Nakanishi, A., Han, X., Saito, H., Taguchi, K., Ohta, Y., Imajoh-Ohmi, S., Miki, Y.
Interference with BRCA2, which localizes to the centrosome during S and early M phase, leads to abnormal nuclear division.
Biochem Biophys Res Commun, 355, 34-40 (2007)
Nguyen, S.T., Hasegawa, S., Tsuda, H., Tomioka, H., Ushijima, M., Noda, M., Omura, K., Miki, Y.
Identification of a predictive gene expression signature of cervical lymph node metastasis in oral squamous cell carcinoma.
Cancer Sci, 98, 740-746 (2007)
Noda, H., Miyaji, Y., Nakanishi, A., Konishi, F., Miki, Y.
Frequent reduced expression of α-1B-adrenergic receptor caused by aberrant promoter methylation in gastric cancers.
Br J Cancer, 96, 383-390 (2007)
Oishi, Y., Nagasaki, K., Miyata, S., Matsuura, M., Nishimura, S., Akiyama, F., Iwai, T., Miki, Y.
Functional pathway characterized by gene expression analysis of supraclavicular lymph node metastasis-positive breast cancer.
J Hum Genet, 52, 271-279 (2007)
Taira, N., Nihira, K., Yamaguchi, T., Miki, Y., Yoshida, K.
DYRK2 is targeted to the nucleus and controls p53 via Ser46 phosphorylation in the apoptotic response to DNA damage.
Mol Cell, 25, 725-738 (2007)
Yamaguchi, T., Kimura, J., Miki, Y., Yoshida, K.
The deubiquitinating enzyme USP11 controls an IκB kinase alpha (IKKα)-p53 signaling pathway in response to tumor necrosis factor α (TNFα).
J Biol Chem, 282, 33943-33948 (2007)
Yamaguchi, T., Miki, Y., Yoshida, K.
Protein kinase C δ activates IκB-kinase α to induce the p53 tumor suppressor in response to oxidative stress.
Cell Signal, 19, 2088-2097 (2007)

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2006年

Hayashi, T., Arai, M., Ueno, M., Kinoshita, H., Tada, Y., Koizumi, K., Miki, Y., Yamaguchi, T., Kato, Y., Utsunomiya, J., Muto, T., Sugihara, K.
Frequency of immunohistochemical loss of mismatch repair protein in double primary cancers of the colorectum and stomach in Japan.
Dis Colon Rectum, 49, S23-29 (2006)
Nagasaki, K., Miki, Y.
Gene expression profiling of breast cancer.
Breast Cancer, 13, 2-7 (2006)
Noda, H., Kato, Y., Yoshikawa, H., Arai, M., Togashi, K., Nagai, H., Konishi, F., Miki, Y.
Frequent involvement of ras-signalling pathways in both polypoid-type and flat-type early-stage colorectal cancers.
J Exp Clin Cancer Res, 25, 235-242 (2006)
Tokairin, Y., Kakinuma, S., Arai, M., Nishimura, M., Okamoto, M., Ito, E., Akashi, M., Miki, Y., Kawano, T., Iwai, T., Shimada, Y.
Accelerated growth of intestinal tumours after radiation exposure in Mlh1-knockout mice: evaluation of the late effect of radiation on a mouse model of HNPCC.
Int J Exp Pathol, 87, 89-99 (2006)
Yoshida, K., Liu, H., Miki, Y.
Protein kinase C δ regulates Ser46 phosphorylation of p53 tumor suppressor in the apoptotic response to DNA damage.
J Biol Chem, 281, 5734-5740 (2006)
Yoshida, K., Yamaguchi, T., Shinagawa, H., Taira, N., Nakayama, K.I., Miki, Y.
Protein kinase C δ activates topoisomerase IIα to induce apoptotic cell death in response to DNA damage.
Mol Cell Biol, 26, 3414-3431 (2006)

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