Clinics & Departments

Clinicopathology Center

Our ActivitiesFeatures of the DepartmentDoctors and Staff

Our Activities

The Clinicopathology Center consists of two departments, the Department of Pathology and the Department of Cytology.

Department of Pathology

The Department of Pathology makes pathological diagnosis that is the final definitive diagnosis of cancer. Our department has many experienced pathologists in the tumor diagnosis who play a leading role throughout Japan. We provide advanced pathological diagnosis directly related to clinical practice, including assessment of tendencies to metastasize and response to treatment.


Cancer treatment begins with pathological diagnosis using biopsy materials. Clinicians take a small amount of tissue from the materials and pathologists diagnose whether or not the lesion is cancer.

Frozen Section Diagnosis

Frozen section diagnosis is performed during surgery to check the histological type and extent of cancer spread. Our department performs the largest number of this diagnosis in Japan.

Diagnosis of Surgical Specimens

Organs resected during surgery are examined in detail and classified pathologically to reveal the pathological characteristics of the cancer.


If patients’ lives could not be saved despite the efforts of the clinical staff and its reason is unclear, we perform post-mortem examination to clarify the pathological nature of tumors and causes of death.

Department of Cytology

Cytology analyzes cell structure to determine whether the cell is benign or malignant with a microscopic observation. We deal with various types of cytology to find the cancer cells: exfoliative cytology, fine-needle aspiration cytology, intraoperative rapid cytology and so on.

Since the procedure of the cytology is minimally invasive and relatively safe, it is often used for cancer screening.

Exfoliative Cytology

Exfoliative cytology examines the cells of the specimens such as urine, sputum, body fluids, and gynecological ones taken from uterine cervix or endometrium. Specimens are processed, stained, and coverslipped for microscopic review by cytotechnologists and cytopathologists.

Fine-Needle Aspiration (FNA) Cytology

FNA cytology examines the cells of the breast, respiratory tract, thyroid, lymph nodes, gastrointestinal tract, hepatobiliary system, pancreas, and so on, with a needle using ultrasonography or endoscopy. Slides for ancillary studies and cell block preparations are made as needed.

Intraoperative Rapid Cytology

Cytologic samples taken during surgery are examined as intraoperative rapid cytology. Slides for ancillary studies and cell block preparations are made as needed.

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Features of the Center

Department of Pathology

The Department of Pathology belongs to both Cancer Institute Hospital and Cancer Institute. We have highly praised physicians and scientists with much experience in cancer diagnosis. Our state-of-the-art researches, covering the most advanced genome science, contribute to the advanced cancer treatment in Cancer Institute Hospital.

Department of Cytology

For the specific and accurate diagnosis, our department use immunocytochemistry technique and cell block preparations for immunohistochemistry. We conduct clinical researches on cytology in collaboration with other departments to develop new diagnostic methods for early cancer detection and to establish cytological methods leading to the development of personalized medicine. In addition, we obtained ISO15189 certification on March 2015.

We also have the School of Cytotechnology in our hospital to foster the excellent cytotechnologists.

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