演題：Causes and Consequences of Aneuploidy in Cancer

演者：Dr. Sarah McClelland

　　　(Professor of Cancer Cell Biology and Genomics Barts Cancer Institute, Queen Mary University of London)

抄録：Chromosomal alterations, such as aneuploidy and DNA copy number variations, are a defining feature of nearly all cancer types, but very little is known about their accumulation mechanisms and functional significance. To tackle these challenges, we take a two-pronged approach: First, to define the mechanisms that cause chromosomal instability and aneuploidy in cancer, we characterize the acute genomic alterations resulting from specific chromosomal instability mechanisms (e.g. replication stress, or mitotic dysfunction) using single cell genomics and cell biology, aiming to track backwards from cancer chromosomal alterations to decipher their origin. Second, to determine the functional consequences of specific chromosomal alterations, we developed a dCas9-based tool to induce a dicentric chromosome with a high propensity to fail chromosome segregation. Using this tool allows for studying the impact of specific chromosomal alterations on cellular behavior.

日　時：2024年11月26日（火）10：00 〜 11 : 00

場　所：セミナー室A/B