演題：Shaping mitotic chromosomes by proper regulation of Condensins:

           Potential role of TopoII, SUMOylation, and remodeling enzyme

演者：Professor Yoshiaki Azuma

           Department of Molecular Biosciences, University of Kansas 

抄録：

  During M-phase in cell cycle, eukaryotic genome undergoes drastic structural rearrangement to form mitotic chromosome, which allows accurate segregation of duplicated genome to daughter cells. In most of eukaryotic cells, this dynamic structural organization of the chromosomes, including condensation of chromosomes, resolution of sister chromatid cohesion, and DNA-entanglement resolution, can be controlled by rearrangement of chromosomal structural protein during M-phase. DNA Topoisomerase II (TopoII) is known for its essential role in these processes as a structural component of mitotic chromosomes as well as an enzyme that resolves entangled genomic DNA. In addition, TopoII is known to be essential for chromosome condensation by cooperating Condensin complex, however how TopoII act on structural organization of mitotic chromosomes is not clearly determined. This presentation, I will discuss our recent findings of molecular mechanisms of TopoII for its interaction to mitotic chromosomes and how that interaction contribute to chromosome segregation in M-phase. In particular, I will discuss our findings on how Condensin complex can be regulated by TopoII, SUMOylation and putative chromatin remodeling enzyme (PICH) to robust mitotic chromosome formation and accurate transmission.

日　時：2025年6月23日（月）10：00 〜 

場　所：セミナー室315