演題：In Vivo Programming of Cancer Immunity with Polymeric Nanomedicine
 
演者：Horacio Cabral博士
         (東京大学大学院工学系研究科　教授)
 
抄録：
Effective cancer immunotherapy demands precise spatial and temporal control of immune function. This seminar presents polymeric nanomedicine strategies for programmable immune activation in vivo. These systems enable targeted delivery of functional proteins as well as in situ protein production via mRNA, installing immune functions directly within tissues and cells. For example, pH-responsive micelles convert potent cytokines, such as IL-12 and IL-15/IL-15Rα, into tumor-restricted signals that drive robust immune responses without systemic toxicity. Beyond cytokine delivery, mRNA nanomedicine enables localized expression of immunomodulators, including light-regulated IL-2 for externally controlled activation against lung metastases. Moving toward next-generation immunotherapy, targeted mRNA delivery to T cells enables specific generation of CD19 CAR-T cells in vivo. Moreover, mRNA nanomedicines reprogram T cell chemotaxis to enhance infiltration into solid tumors, improving therapeutic efficacy of immune checkpoint inhibitors. Together, these advances position nanomedicine as a platform for programming immune function in vivo, shifting cancer immunotherapy from systemic intervention to precise, in situ engineering. 
 
日　時：２０２６年 ５月 ２５日（月） １８：００〜１９：００
場　所：吉田記念講堂