がん研セミナー（10月3日）のお知らせ

演題：Targeting the pancreas cancer neo-organ

演者：Sunil R. Hingorani, M.D., Ph.D.（Raisbeck Chair in Pancreatic ResearchnMember, Fred Hutchinson Cancer Research CenterProfessor, University of Washington School of Medicine）

抄録：Pancreatic ductal adenocarcinoma co-opts multiple cellular and extracellular mechanisms to create a complex cancer organ with an unusual proclivity for metastasis and resistance to therapy.  Cell-autonomous events are essential for the initiation and maintenance of pancreatic ductal adenocarcinoma, but recent studies have implicated critical non-cell autonomous processes within the robust desmoplastic stroma that promote disease pathogenesis and resistance.  Thus, non-malignant cells and associated factors are culprits in tumor growth, immunosuppression, and invasion.  However, even this increasing awareness of non-cell autonomous contributions to disease progression is tempered by the conflicting roles stromal elements can play.  A greater understanding of stromal complexity and complicity has been aided in part by studies in highly faithful genetically engineered mouse models of pancreatic ductal adenocarcinoma.  Insights gleaned from such studies are spurring the development of therapies designed to re-engineer the pancreas cancer stroma and render it permissive to agents targeting cell-autonomous events or to reinstate immunosurveillance.  Integrating conventional and immunological treatments in the context of stromal targeting may provide the key to a durable clinical impact on this formidable disease.

日時：２０１８年 １０月 ３日（水） １８：００〜１９：００

場所：吉田記念講堂

連絡先：丸山玲緒（内線５２６２）

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