1. Histological criteria for effectiveness of chemo- and radio-therapy for gastrointestinal tumors
  2. Study of premalignant and in-situ carcinoma for Bile-duct and pancreas group
  3. Histopathological study towards selection of treatment modalities and outcome prediction in head and neck cancer
  4. Studies by Breast Group
  5. Hepatocarcinogenesis using experimental liver cancer models
  6. Pathological studies for gynecological malignancies
  7. Diagnostic and etiologic studies for lung cancers
  8. Clinicopathological studies with aids of chromosome analysis for genitourinary cancers
  9. Pathological and molecular studies for bone and soft tissue tumors
  10. Pathological and molecular studies for hematological neoplasms

Histological criteria for effectiveness of chemo- and radio-therapy for gastrointestinal tumors

The gastrointestinal (GI) group

Members: Drs. Y. Kato, N. Yamamoto, K. Kubo,
H.Ninomiya, Y. Miwa, I.Ohnishi, T.Yoshimoto.

The GI group performs routine diagnosis of materials, both biopsy and surgery, approximately 900 cases annually. Research activities are largely based on the surgical and endoscopical materials taken at the Cancer Institute Hospital. Research topics are as follows:

  1. Superficial carcinoma without lymphnode metastasis.
    We histologically pursue application limits of endoscopic mucosal resection (EMR) in terms of what extent of invasion we can remove carcinomas with submucosal invasion to.
  2. Histological criteria for effectiveness of chemo- and radio-therapy, and histological characteristics of cancers sensitive/resistant to chemo- and radio-therapy.
    We develop methods for evaluating easily and precisely how much tumors have been degenerated at primary and metastatic sites using neo-adjuvant cases.
  3. Histological and molecular characteristics of tumors of high-grade and low-grade malignancy.
    We analyze histologically and molecular-biologically high-grade malignant tumors such as small cell carcinoma (neuroendocrine carcinoma) as well as low-grade malignant ones such as medullary carcinomas with lymphocytic infiltration.
  4. State of stroma and malignancy grade in advanced carcinomas.
    We focus on relationships of development of stroma such as blood vessels and fibrous tissues with malignancy grade of tumors.
  5. Establishment of detection system for hereditary cancers (familial cancers), particularly HNPCC, and analyses of small mucosal lesions associated with HNPCC, together with the Gene Therapy Center and Department of Genetic Diagnosis,
  6. Studies on premalignant, in-situ and intramucosal carcinomas.
    For esophageal lesions, we established differentiation methods of dysplasias and in-situ carcinomas, and are studying clinicopathological implications of geographical esophagus. For gastric tumors, we continue to analyze characters of well-differentiated carcinomas with a highly invasive nature. For colonic lesion, we are examining carcinomas showing a sequence from metaplastic polyp through serrated adenoma and to carcinoma.

Return to Top of Page