Laboratories

Publications

Update : 2022/04/14

Contents

  1. Original articles
  2. Reviews and book chapters

Original articles

2021｜2020｜2019｜2018｜2016｜2015｜2014｜2013｜2012｜2011｜2010｜2009｜2008｜2007｜2006

2021

Uchida, KSK., Jo, M., Nagasaka, K., Takahashi, M., Shindo, N., Shibata, K., Tanaka, K., Masumoto, H., Fukagawa, T., and Hirota, T.
Kinetochore stretching-mediated rapid silencing of the spindle-assembly checkpoint required for failsafe chromosome segregation.
Curr. Biol, 31: 1581-1591 (2021)
Shindo, N., Otsuki, M., Uchida, KSK., and Hirota, T.
Prolonged mitosis causes separase deregulation and chromosome nondisjunction.
Cell Rep, 34: 108652 (2021)
Matsui, S., and Nozawa, R.S.
RNA impacts formation of biomolecular condensates in the nucleus.
Biomed. Res, 42: 153-160 (2021)
Yoshida, R., Hagio, T., Kaneyasu, T., Gotoh, O., Osako, T., Tanaka, N., Amino, S., Yaguchi, N., Nakashima, E., Kitagawa, D., Ueno, T., Ohno, S., Nakajima, T., Nakamura, S., Miki, Y., Hirota, T., Takahashi, S., Matsuura, M., Noda, T., and Mori, S.
Pathogenicity assessment of variants for breast cancer susceptibility genes based on BRCAness of tumor sample.
Cancer Sci, 112: 1310-1319 (2021)
Miyata, K., Imai, Y., Hori, S., Nishio, M., Loo, T.M., Okada, R., Yang, L., Nakadai, T., Maruyama, R., Fujii, R., Ueda, K., Jiang, Li., Zheng, H., Toyokuni, S., Sakata, T., Shirahige, K., Kojima, R., Nakayama, M., Oshima, M., Nagayama, S., Seimiya, H., Hirota, T., Saya, H., Hara, E. and Takahashi, A.
Pericentromeric noncoding RNA changes DNA binding of CTCF and inflammatory gene expression in senescence and cancer.
Proc. Natl. Acad. Sci. USA, 118: e2025647118 (2021)
Rii, J., Sakamoto, S., Sugiura, M., Kanesaka, M., Fujimoto, A., Yamada, Y., Maimaiti, M., Ando, K., Wakai, K., Xu, M., Imamura, Y., Shindo, N., Hirota, T., Kaneda, A., Kanai, Y., Ikehara, Y., Anzai, N., Ichikawa, T.
Functional analysis of LAT3 in prostate cancer: its downstream target and relationship with androgen receptor.
Cancer Sci, 112: 3871-3883 (2021)

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2020

Fujimura, A., Hayashi, Y., Kato, K., Kogure, Y., Kameyama, M., Shimamoto, H., Daitoku, H., Fukamizu, A., Hirota, T., Kimura, K.
Identification of a novel nucleolar protein complex required for mitotic chromosome segregation through centromeric accumulation of Aurora B.
Nucleic Acids Res. 48: 6583-6596 (2020)
Watson, N.A., Cartwright, T.N., Lawless, C., Camara-Donoso, M., Sen, O., Sako, K., Hirota, T., Kimura, H., Higgins, J.M.G.
Kinase iinhibition profiles as a tool to identify kinases for specific phosphorylation sites.
Nature Commun. 11: 1684 doi: 10.1038/s41467-020-15428-0 (2020)
Boteva, L., Nozawa, R. S., Naughton, C., Samejima, K., Earnshaw, W. C., Gilbert, N.
Common fragile sites are characterized by faulty condensin loading after replication stress.
Cell Rep. 32 (12) 108177 (2020)
Kinjo, K., Nagasaki, K., Muroya, K., Suzuki, E., Ishiwata, K., Nakabayashi, K., Hattori, A., Nagao, K., Nozawa, R. S., Obuse, C., Miyado, K., Ogata, T., Fukami, M., and Miyado, M.
Rare variant of the epigenetic regulator SMCHD1 in a patient with pituitary hormone deficiency.
Sci. Rep. 10: 10985 (2020)

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2019

Nishibuchi, G., Machida, S., Nakagawa, R., Yoshimura, Y., Hiragami-Hamada, K., Abe, Y., Kurumizaka, H., Tagami, H., and Nakayama, J. I.
Mitotic phosphorylation of HP1α regulates its cell cycle-dependent chromatin binding.
J. Biochem. 165: 433-446 (2019)
Nishimura, K., Johmura, Y., Deguchi, K., Jiang, Z., Uchida, KSK., Suzuki, N., Shimada, M., Chiba, Y., Hirota, T., Yoshimura, SH., Kono, K,. Nakanish, M.
Cdk1-mediated DIAPH1 phosphorylation maintains metaphase cortical tension and inactivates the spindle assembly checkpoint at anaphase.
Nature Commun. 10: 981-993 (2019)
Nakayama, I., Shinozaki, E., Sakata, S., Yamamoto, N., Fujisaki, J., Muramatsu, Y., Hirota, T., Takeuchi, K., Takahashi, S., Yamaguchi, K., Noda, T.
Enrichment of CLDN18-ARHGAP fusion gene in gastric cancers in young adults.
Cancer Sci. 110: 1352-1363 (2019)

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2018

Konishi, M., Shindo, N., Komiya, M., Tanaka, K., Itoh, T. and Hirota, T.
Quantitative analyses of the metaphase-to-anaphase transition reveal differential kinetic regulation for securin and cyclin B1.
Biomed Res. 39: 75-85 (2018)
Takahashi, M., and Hirota, T.
Dynamics of sister chromatids through the cell cycle: Together and apart. Spotlight.
J Cell Biol. 217: 1887-1889 (2018)
Hayashi, Y., Fujimura, A., Kato, K., Udagawa, R., Hirota, T., and Kimura, K.
Nucleolar integrity during interphase supports faithful Cdk1 activation and mitotic entry.
Sci Adv. 4: eaap7777 (2018)

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2016

Y. Abe and T. Hirota.
System-level deficiencies in Aurora B control in cancers.
Cell cycle, 15, 2091-2092 (2016)
Y. Abe, K. Sako, K. Takagaki, Y. Hirayama, K. S. Uchida, J. A. Herman, J. G. DeLuca and T. Hirota.
HP1-assisted aurora B kinase activity prevents chromosome segregation errors.
Developmental cell, 36, 487-97 (2016)
K. Nagasaka, M. J. Hossain, M. J. Roberti, J. Ellenberg and T. Hirota.
Sister chromatid resolution is an intrinsic part of chromosome organization in prophase.
Nature cell biology, 18, 692-9 (2016)
M. Takahashi, K. Tanaka, T. Wakai and T. Hirota.
Phosphoproteomic analysis of human mitotic chromosomes identified a chromokinesin KIF4A.
Biomedical research, 37, 161-5 (2016)
M. Takahashi, T. Wakai and T. Hirota.
Condensin I-mediated mitotic chromosome assembly requires association with chromokinesin KIF4A.
Genes & development, 30, 1931-6 (2016)
K. Tanaka and T. Hirota.
Chromosomal instability: A common feature and a therapeutic target of cancer.
Biochimica et biophysica acta, 1866, 64-75 (2016)

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2015

Minamino, M., Ishibashi, M., Nakato, R., Akiyama, K., Tanaka, H., Kato, Y., Negishi, L., Hirota, T., Sutani, T., Bando, M., Shirahige, K.
Esco1 acetylates cohesin via a mechanism different from that of Esco2.
Curr Biol, 25, 1694-1706 (2015)
Nagasaka, K., Hirota, T.
Clarifying the role of condensin in shaping chromosomes.
Nat Cell Biol, 17, 711-713 (2015)

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2014

Gallego-Paez, L.M., Tanaka, H., Bando, M., Takahashi, M., Nozaki, N., Nakato, R., Shirahige, K., Hirota, T.
Smc5/6-mediated regulation of replication progression contributes to chromosome assembly during mitosis in human cells.
Mol Biol Cell, 25, 302-317 (2014)

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2013

Earnshaw, W.C., Allshire, R.C., Black, B.E., Bloom, K., Brinkley, B.R., Brown, W., Cheeseman, I.M., Choo, K.H.A., Copenhaver, G.P., DeLuca, J.G., Desai, A., Diekmann, S., Erhardt, S., Fitzgerald-Hayes, M., Foltz, D., Fukagawa, T., Gassmann, R., Gerlich, D.W., Glover, D.M., Gorbsky, G.J., Harrison, S.C., Heun, P., Hirota, T., Jansen, L.E.T., Karpen, G., Kops, G.J.P., Lampson, M.A., Lens, S.M., Losada, A., Luger, K., Maiato, H., Maddox, P.S., Margolis, R.L., Masumoto, H., McAinsh, A.D., Mellone, B.G., Meraldi, P., Musacchio, A., Oegema, K., O'Neill, R.J., Salmon, E.D., Scott, K., Straight, A.F., Stukenberg, P.T., Sullivan, B.A., Sullivan, K.F., Sunkel, C.E., Swedlow, J.R., Walczak, C.E., Warburton, P.E., Westermann, S., Willard, H.F., Wordeman, L., Yanagida, M., Yen, T.J., Yoda, K., Cleveland, D.W.
Esperanto for Histones: CENP-A, not CenH3, is the centromeric histone H3 variant. Commentary.
Chromosome Res, 21, 101-106 (2013)
Itoh, G., Sugino, S., Mizuguchi, M., Kanno, S., Amin, M.A., Iemura, K., Ikeda, M., Yasui, A., Hirota, T., Tanaka, K.
The nucleoporin Nup188 is required for chromosome alignment in mitosis.
Cancer Sci, 104, 871-879 (2013)
Ando, K., Ozaki, T., Hirota, T., Nakagawara, A.
NFBD1/MDC1 Is Phosphorylated by PLK1 and Controls G2/M Transition through the Regulation of a TOPOIIalpha-Mediated Decatenation Checkpoint.
PLoS One, 8, e82744 (2013)

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2012

Kumada, K., Hirota, T.
Separase. Review.
In Handbook of Proteolytic Enzymes, Rawlings, N.D., Salvesen, G., ed., (London, Elsevier), (2012)
Deardorff, M.A., Bando, M., Nakato, R., Watrin, E., Itoh, T., Minamino, M., Saitoh, K., Komata, M., Katou, Y., Clark, D., Cole, K.E., De Baere, E., Decroos, C., Di Donato, N., Ernst, S., Francey, L.J., Gyftodimou, Y., Hirashima, K., Hullings, M., Ishikawa, Y., Jaulin, C., Kaur, M., Kiyono, T., Lombardi, P.M., Magnaghi-Jaulin, L., Mortier, G.R., Nozaki, N., Petersen, M.B., Seimiya, H., Siu, V.M., Suzuki, Y., Takagaki, K., Wilde, J.J., Willems, P.J., Prigent, C., Gillessen-Kaesbach, G., Christianson, D.W., Kaiser, F.J., Jackson, L.G., Hirota, T., Krantz, I.D., Shirahige, K.
HDAC8 mutations in Cornelia de Lange syndrome affect the cohesin acetylation cycle.
Nature, 489, 313-317 (2012)
Shindo, N., Kumada, K., Hirota, T.
Separase-sensor reveals dual roles for separase coordinating cohesin cleavage and cdk1 inhibition.
Dev Cell, 23, 112-123 (2012)

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2011

*Abe, S., *Nagasaka, K., Hirayama, Y., Kozuka-Hata, H., Oyama, M., Aoyagi, Y., Obuse, C., Hirota, T., (*equal-contribution).
The initial phase of chromosome condensation requires Cdk1-mediated phosphorylation of the CAP-D3 subunit of condensin II.
Genes Dev, 25, 863-874 (2011)
Itoh, G., Kanno, S., Uchida, K.S.K., Chiba, S., Sugino, S., Watanabe, K., Mizuno, K., Yasui, A., Hirota, T., Tanaka, K.
CAMP (C13orf8, ZNF828) is a novel regulator of kinetochore-microtubule attachment.
EMBO J, 30, 130-144 (2011)
Nagasaka, K., Gallego-Paez, L.M., Hirota, T.
Mitosis and meiosis: Molecular control of chrmosome separation. Review.
In Encyclopedia of Life Sciences, (John Wiley & Sons, Ltd.), (2011)
Smith, E., Hegarat, N., Vesely, C., Roseboom, I., Streicher, H., Straataman, K., Flynn, H., Skehel, M., Hirota, T., Kuriyama, R., Hochegger, H.
Differential control of Eg5 dependent centrosome separation by Plk1 and Cdk1.
EMBO J, 30, 2233-2245 (2011)

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2010

Abe, Y., Okumura, E., Hosoya, T., Hirota, T., Kishimoto, T.
A single starfish Aurora kinase performs the combined functions of Aurora-A and Aurora-B in human cells.
J Cell Sci, 123, 3978-3988 (2010)
Arai, D., Katsura, H., Shindo, N., Matsumoto, M., Higashinakagawa, T.
Polycomb group protein Ezh1 represses Nodal and maintains the left-right axis.
Dev Biol, 341, 459-463 (2010)
Kodama, M., Otsubo, C., Hirota, T., Yokota, J., Enari, M., Taya, Y.
Requirement of ATM for rapid p53 phosphorylation at Ser46 without Ser/Thr-Gln sequences.
Mol Cell Biol, 30, 1620-1633 (2010)
Nozawa, R.S., Nagao, K., Masuda, H.T., Iwasaki, O., Hirota, T., Nozaki, N., Kimura, H., Obuse, C.
Human POGZ modulates dissociation of HP1α from mitotic chromosome arms through Aurora B activation.
Nat Cell Biol, 12, 719-727 (2010)
Ohishi, T., Hirota, T., Tsuruo, T., Seimiya, H.
TRF1 mediates mitotic abnormalities induced by Aurora-A overexpression.
Cancer Res, 70, 2041-2052 (2010)

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2009

Tanaka, K., Hirota, T.
Chromosome segregation machinery and cancer.
Cancer Sci, 100, 1158-1165 (2009)
Uchida, K.S., Takagaki, K., Kumada, K., Hirayama, Y., Noda, T., Hirota, T.
Kinetochore stretching inactivates the spindle assembly checkpoint.
J Cell Biol, 184, 383-390 (2009)
Tanuma, N., Nomura, M., Ikeda, M., Kasugai, I., Tsubaki, Y., Takagaki, K., Kawamura, T., Yamashita, Y., Sato, I., Sato, M., Katakura, R., Kikuchi, K., Shima, H.
Protein phosphatase Dusp26 associates with KIF3 motor and promotes N-cadherin-mediated cell-cell adhesion.
Oncogene, 28, 752-761 (2009)

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2008

Johnson, B.V., Shindo, N., Rathjen, P.D., Rathjen, J., Keough, R.A.
Understanding pluripotency--how embryonic stem cells keep their options open.
Mol Hum Reprod, 14, 513-520 (2008)
Matsuoka, O., Shindo, N., Arai, D., Higashinakagawa, T.
A histone H1 variant is required for erythrocyte maturation in medaka.
Int J Dev Biol, 52, 887-892 (2008)
Munirajan, A.K., Ando, K., Mukai, A., Takahashi, M., Suenaga, Y., Ohira, M., Koda, T., Hirota, T., Ozaki, T., Nakagawara, A.
KIF1Bβ functions as a haploinsufficient tumor suppressor gene mapped to chromosome 1p36.2 by inducing apoptotic cell death.
J Biol Chem, 283, 24426-24434 (2008)
Zhang, D., Shimizu, T., Araki, N., Hirota, T., Yoshie, M., Ogawa, K., Nakagata, N., Takeya, M., Saya, H.
Aurora A overexpression induces cellular senescence in mammary gland hyperplastic tumors developed in p53-deficient mice.
Oncogene, 27, 4305-4314 (2008)

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2007

Nakajima, M., Kumada, K., Hatakeyama, K., Noda, T., Peters, J.M., Hirota, T.
The complete removal of cohesin from chromosome arms depends on separase.
J Cell Sci, 120, 4188-4196 (2007)
Lipp, J.J., Hirota, T., Poser, I., Peters, J.M.
Aurora B controls the association of condensin I but not condensin II with mitotic chromosomes.
J Cell Sci, 120, 1245-1255 (2007)
Nakajima, M., Kumada, K., Hatakeyama, K., Noda, T., Peters, J.M., Hirota, T.
The complete removal of cohesin from chromosome arms depends on separase.
J Cell Sci, 120, 4188-4196 (2007)

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2006

Gerlich, D., Hirota, T., Koch, B., Peters, J.M., Ellenberg, J.
Condensin I stabilizes chromosomes mechanically through a dynamic interaction in live cells.
Curr Biol, 16, 333-344 (2006)

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