部門紹介

研究業績

最終更新日 : 2020年8月5日

目次

  1. 原著論文
  2. 総説・解説や教科書など

原著論文

2020年

Nozawa, R., Yamamoto, T., Takahashi, M., Tachiwana, H., Maruyama, R., Hirota T., Saitoh, N.*
Nuclear microenvironment in cancer: control through liquid-liquid phase separation. Cancer Sci, doi: 10.1111/cas.14551, 2020
Yamamoto, T .#, Hirosue, A #*, Nakamoto, M., Yoshida, R., Sakata, J., Matsuoka, Y., Kawahara, K., Nagao, Y., Nagata, M., Takahashi, N., Hiraki, A., Shinohara, M., Nakao, M., Saitoh, N.*, Nakayama, H.
BRD4 promotes metastatic potential in oral squamous cell carcinoma through the epigenetic regulation of the MMP2 gene. British Journal of Cancer, doi: 10.1038/ s41416-020-0907-6,  2020
Ochiai, H.*, Hayashi T., Umeda, M., Yoshimura, M., Harada, A., Shimizu, Y., Nakano, K., Saitoh, N., Liu, Z., Yamamoto, T., Okamura, T., Ohkawa, Y., Kimura, H., Nikaido, I.*
Genome-wide analysis of kinetic properties of transcriptional bursting in mammalian cells. Science Advances, 6(25), eaaz6699, 2020
Tachiwana, H., Yamamoto, T., Saitoh, N.*
Gene regulation by non-coding RNAs in the 3D genome architecture. Current Opinion in Genetics and Development, 61, 69–74, 2020
Fujita, R.#, Yamamoto, T.#, Arimura, Y., Fujiwara, S., Tachiwana, H., Ichikawa, Y., Sakata, Y., Yang, L., Maruyama, R., Hamada, M., Nakao, M., Saitoh, N.*, Kurumizaka, H.*
Nucleosome destabilization by nuclear non-coding RNAs. Commun. Biology, 3 (1), 60, 2020 
Yasuda, Y., Tokunaga, K., Koga, T., Goldberg, I., Sakamoto, C., Saitoh, N.*, Nakao, M.*
Computational analysis of morphological and molecular features in gastric cancer tissues. Cancer Medicine, Cancer Medicine, 9(6), 2223-2234, 2020
Miyazaki, K., Ichikawa, Y., Saitoh, N., Saitoh, H.*
Three Types of Nuclear Envelope Assemblies Associated with Micronuclei. Cell Bio, 9, 14-28, 2020

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2019年

Abdalla, M.O.A., Yamamoto, T., Maehara, K., Ohkawa, Y., Miura, H., Hiratani, I., Nakayama, H., Nakao, M., and Saitoh, N.*
The Eleanor ncRNAs activate the topological domain of the ESR1 locus to balance against apoptosis. Nat. Commun, 10(1), 3778, 2019
Yamamoto, T., Saitoh, N.*
Non-coding RNAs and chromatin domains. Curr Opin Cell Biol. 58, 26-33, 2019

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2018年

Yamamoto, T.#, Sakamoto,C. #, Tachiwana, H., Kumabe, M., Matsui, T., Yamashita, T., Shinagawa, M., Ochiai, K., Saitoh, N.*, Nakao, M.*
Endocrine therapy-resistant breast cancer model cells are inhibited by soybean glyceollin I through Eleanor non-coding RNA. Sci. Rep 8:15202, 2018
Ichikawa, Y., Saitoh, N., Kaufman, P.D.*
An asymmetric centromeric nucleosome. eLife, 7, e37911, 2018
Takagi, M., Ono, Y., Natsume, T., Sakamoto, C., Nakao, M., Saitoh, N., Kanemaki, M.T., Hirano, T. Imamoto, N
Ki-67 and condensins support the integrity of mitotic chromosomes through distinct mechanisms. J. Cell Sci, 131(6), jcs212092, 2018

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2017年

Dobrucki, J., Saitoh, N.
The 4D Nucleome in Kraków-prospects for an emerging field. Nucleus, 8(5), 447-448, 2017
Ono, T., Sakamoto, C., Nakao, N., Saitoh, N., Hirano, T.*
Condensin II plays an essential role in reversible assembly of mitotic chromosomes in situ. Mol. Biol. Cell, 28, 2875-2886, 2017
Wang, X., Liang, S., Sun, Y., Li, H., Endo, F., Nakao, M., Saitoh, N.*, Wu, L*
Analysis of estrogen receptor beta gene methylation in autistic males in a Chinese Han population. Metab Brain Dis 32(4), 1033-1042, 2017
Tanaka, H., Takebayashi, SI., Sakamoto, A., Igata, T., Nakatsu, Y., Saitoh, N., Hino, S., Nakao, M.*
The SETD8/PR-Set7 Methyltransferase Functions as a Barrier to Prevent Senescence-Associated Metabolic Remodeling. Cell Rep, 18:2148-2161, 2017

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2016年

Tomita, S., Abdalla, M. O. A., Fujiwara, S., Yamamoto, T., Iwase, H., Nakao, M.*, Saitoh, N.*
Roles of long non-coding RNAs in chromosome domains. Wiley Interdisciplinary Review RNA, 8(2), 2016
Nakayama, T., Saitoh, N., Morotomi-Yano, K., Yano, K.I., Nakao, M., Saitoh, H.*
Nuclear extrusion precedes discharge of genomic DNA fibers during tunicamycin-induced neutrophil extracellular trap-osis (NETosis)-like cell death in cultured human leukemia cells. Cell Biol Int, 40(5), 597-602, 2016
Matsumoto, A., Sakamoto, C., Matsumori, H., Katahira, J., Yasuda, Y., Yoshidome, K., Tsujimoto, M., Goldberg, I. G., Matsuura, N., Nakao, M., Saitoh, N.*, Hieda, M.*
Loss of the integral nuclear envelope protein SUN1 induces alteration of nucleoli. Nucleus, 7, 68-83, 2016

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2015年

Kitamura, H., Matsumori, H., Kalendova, A., Hozak, P., Goldberg, I.G., Nakao, M., Saitoh, N., Harata, M.*
The actin family protein ARP6 contributes to the structure and the function of the nucleolus. Biochem. Biophys. Res. Commun. 464(2), 554-560, 2015
Tomita, S., Abdalla, M. O. A., Fujiwara, S., Matsumori, H., Maehara, K., Ohkawa, Y., Iwase, H., Saitoh, N.*, Nakao, M.*
A cluster of noncoding RNAs activates the ESR1 locus during breast cancer adaptation. Nat. Commun 6, 6966, 2015

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2014年

Tokunaga, K., Saitoh, N*., Goldberg, I. G., Sakamoto, C., Yasuda, Y., Yoshida, Y., Yamanaka, S. and Nakao, M.*
Computational image analysis of colony and nuclear morphology to evaluate human induced pluripotent stem cells. Sci. Rep, 4, 6996, 2014.

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2013年

Sasai, N., Saitoh, N., Saitoh, H., Nakao, M.*
The transcriptional cofactor MCAF1/ATF7IP is involved in histone gene expression and cellular senescence. PLoS ONE 8 (7), e68478, 2013

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2012年

Hirosue, A., Ishihara, K., Tokunaga, K., Watanabe T., Saitoh N., Nakamoto M, Chandra T., Narita M., Shinohara M., Nakao M.
Quantitative assessment of higher-order chromatin structure of the INK4/ARF locus in human senescent cells. Aging Cell 11, 553-556, 2012.
Saitoh, N*, Sakamoto, C., Hagiwara, M., Agredano-Moreno, L. T., Jiménez-García, L. T.,  Nakao, M
The distribution of phosphorylated SR proteins and alternative splicing are regulated by RANBP2. Mol. Biol. Cell 23, 1115-1128, 2012.

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2009年

Tei, S., Saitoh, N., Funahara, T., Iida, I., Nakatsu, Y., Kinoshita K., Kinoshita, Y., Saya, H.,  Nakao, M.*
Simian virus 40 large T antigen targets the microtubule- stabilizing protein TACC2. J. Cell Sci. 122, 3190-3198, 2009.
Liu, L., Ishihara, K., Ichimura, T, Fujita, N., Hino, S., Tomita, S., Watanabe, S., Saitoh, N., Ito, T., Nakao, M.*
MCAF1/AM is involved in Sp1-mediated maintenance of cancer-associated telomerase activity. J. Biol. Chem. 284, 5165-5174, 2009.

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2008年

Aoto, T., Saitoh, N*., Sakamoto, Y., Watanabe, S., and Nakao, M*.
Polycomb group-associated chromatin is reproduced in post-mitotic G1 phase and required for S-phase progression. J Biol Chem 283, 18905-18915, 2008.

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2007年

Ueda, Y., Watanabe, S., Tei, S., Saitoh, N., Kuratsu, J.I., Nakao, M.*
High mobility group protein HMGA1 inhibits retinoblastoma protein-mediated cellular G0 arrest. Cancer Sci. 98, 1893-1901, 2007.

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2006年

Aoto, T., Saitoh, N., T. Ichimura, Niwa, H., Nakao, M.*
Nuclear and chromatin reorganization in the MHC-Oct3/4 locus at developmental phases of embryonic stem cell differentiation. Dev. Biol, 208, 354-367, 2006
Saitoh, N., Uchimura, U., Tachibana, T., Sugahara, S., Saitoh, H., Nakao, M.*
In situ SUMOylation analysis reveals a modulatory role of RanBP2 in the nuclear rim and PML bodies. Exp. Cell Res, 312, 1418-1430, 2006

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2004年

Saitoh, N., Spahr, C. S., Patterson, S.D., Bubulya, P., Neuwald, A.F, and Spector, D.L*.
Proteomics analysis of interchromatin granule clusters. Mol Biol Cell 15, 3876-3890, 2004.

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2003年

Nishijima, H., Nishitani, H., Saitoh, N., Nishimoto, T.*
Caffeine mimics adenine and 2’-deoxyadenosine, both of which inhibit the guanin-nucleotide exchange activity of RCC1 and the kinase activity of ATR. Genes to Cells. 8, 423-435, 2003
Matsuzaki, K., Minami, T., Tojo, M., Honda, Y., Saitoh, N., Nagashiro, S., Saya, H., Nakao, M.*
PML-nuclear bodies are involved in cellular serum response. Genes to Cells, 8, 275-286, 2003

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2000年

Saitoh, N., West, A., Recillas-Targa, F., Pikaart,M.J., and Felsenfeld, G*.
Structural and functional conservation at the boundaries of the chicken beta-globin domain. EMBO J 19, 2315-2322, 2000.

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1999年

Bulger, M., von Doorninck, J. H., Saitoh, N., Telling, A., Farrell, C., Bender, M. A., Felsenfeld, G., Axel, R., Groudine, M.*
Conservation of sequence and structure flanking the mouse and human beta-globin loci: the beta-globin genes are embedded within an array of odorant receptor genes. Proc Natl Acad Sci U S A, 96, 5129-5134, 1999

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1998年

Bell, A., Boyes, J., Chung, J., Pikaart, M., Prioleau, M. N., Recillas, F., Saitoh, N., Felsenfeld, G.*
The establishment of active chromatin domains. Cold Spring Harb Symp Quant Biol, 63, 509-514, 1998
Bell, A.C., Pikaart, M.J., Prioleau, M.N., Rcillas-Targa, F., Saitoh N., West, A.G., Felsenfeld, G.*
Insulators and boundaries in the chicken b-globin locus. BCMD, 24(22), 464-465, 1998

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1995年

Saitoh, N., Goldberg, I. G., Earnshaw, W. C.*
The SMC proteins and the coming of age of the chromosome scaffold hypothesis. Bio Essays,  17, 759-766, 1995

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1994年

Saitoh, N., Goldberg, I. G., Wood, E. R., and Earnshaw, W. C*.
ScII: An abundant chromosome scaffold protein is a member of a family of putative ATPases with an unusual predicted tertiary structure. J Cell Biol 127, 303-318, 1994.

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1993年

Ma,X., Saitoh, N., Curtis P.*
Purification and characterization of a nuclear DNA-binding factor complex containing topoisomerase II and chromosome scaffold protein 2. J. Biol. Chem, 268, 6182-6188, 1993

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1992年

Pluta, A. F., Saitoh, N., Goldberg, I., Earnshaw, W. C.*
Identification of a subdomain of CENP-B that is necessary and sufficient for localization to the human centromere. J. Cell Biol, 116, 1081-1093, 1992

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1989年

Ishihara, H.*, Hara, N., and Iwabuchi, T.
Molecular cloning and expression in Escherichia coli of the Bacillus licheniformis Bacitracin Synthetase 2 Gene. J. Bacteriol, 171, 1705-1711, 1989

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