部の紹介
病理部長 竹内 賢吾
病理部は、 病院のための診断活動を高いレベルで遂行すると共に、 主として診断と予防に関する研究活動を行っています。特に近年は、 がんの個別化医療実現のための"癌研ゲノムプロジェクト"に積極的に参加し、 化学療法や放射線療法のより正確な組織学的効果判定基準の確立と、 各臓器がんの組織学的治療感受性診断学の前進に努めています。また、 外科的・内視鏡的切除材料の断端診断学を高度化し、 最も合理的な術後治療方針の決定に貢献してきています。さらに、 各臓器の前がん病変や早期がんの形質と遺伝子変化の解析および長期追跡を通じ、 病変の性格、 特に悪性転化ポテンシャルを明らかにしようとしています。
未来の展望
癌研では、研究所に病理部があり、病院の病理部を兼ねています。それゆえ、伝統的に病院と研究所、あるいは研究型の各部門を結ぶ要として機能してきました。今後も高度な病理診断を提供するのみでなく、癌研の特質でもある協調性や総合性をいっそう促進する存在となるよう努める決意です。病院で切除された手術材料を系統的に収集・保管して研究に役立てるGanken Tissue Bankも病理部を中心に運営されますし、遺伝子変換マウスにおける病理解析にも、ヒトの病気の形態学に関する知識の蓄積のある病理が積極的に参加するのが良いと考えています。形態学診断は、今後、遺伝子発現解析により治療感受性指標が確立されていく過程で重要なだけでなく、その結果を取り込むことで、自らも飛躍させることができると考えられるので、その方向の研究も加速させたいと考えています。
研究内容
- 治療効果判定法などに関する消化管グループの研究
- 胆膵グループによる前癌病変・上皮内がんの研究
- 治療選択への寄与を目指す頭頚部グループの研究
- 乳癌グループの研究
- 実験肝癌モデルを用いた肝がんの発がんメカニズムの研究
- 婦人科がんの病理学的研究
- 肺がんの診断,原因を追求する臨床病理学的,分子生物学的研究
- 泌尿器科腫瘍の臨床病理学的研究 - 染色体解析も援用して
- 骨軟部腫瘍の病理学的研究
- 血液腫瘍の病理学的,分子生物学的研究
- ヒト発癌に関する病理学的研究 - 環境因子・遺伝性因子に注目して
代表論文
2022年|2021年|2020年|2019年|2018年|2017年|2016年
2022年
- Hayashi, K., Ono, Y., Takamatsu, M., Oba, A., Ito, H., Sato, T., Inoue, Y., Saiura, A., Takahashi, Y.
- Prediction of recurrence pattern of pancreatic cancer post-pancreatic surgery using histology-based supervised machine learning algorithms: A single-center Retrospective study.
Ann. Surg. Oncol., 29 (7): 4624-4634, 2022 - Ishii, S., Takamatsu, M., Ninomiya, H., Inamura, K., Horai, T., Iyoda, A., Honma, N., Hoshi, R., Sugiyama, Y., Yanagitani, N., Mun, M., Abe, H., Mikami, T., Takeuchi, K.
- Machine learning-based gene alteration prediction model for primary lung cancer using cytologic images.
Cancer Cytopathol., 130 (10): 812-823, 2022 - Kunieda, J., Yamashita, K., Togashi, Y., Baba, S., Sakata, S., Inamura, K., Ae, K., Matsumoto, S., Machinami, R., Kitagawa, M., Takeuchi, K.
- High prevalence of TERT aberrations in myxoid liposarcoma: TERT reactivation may play a crucial role in tumorigenesis.
Cancer Sci., 113 (3): 1078-1089, 2022 - Ninomiya, H., Inamura, K., Mun, M., Nishio, M., Ishikawa, Y.
- Relationship between pathologic T1 categories and pathologic factors affecting prognosis in pulmonary adenocarcinoma.
JTO Clin. Res. Rep., 3 (4): 100293, 2022 - Osako, T., Kurisaki-Arakawa, A., Dobashi, A., Togashi, Y., Baba, S., Shiozawa, S., Ishigame, H., Ishige, H., Ohno, S., Ishikawa, Y., Takeuchi, K.
- Distinct clinicopathologic features and possible pathogenesis of localized ALK-positive histiocytosis of the breast.
Am. J. Surg. Pathol., 46 (3): 344-352, 2022 - Osako, T., Matsuura, M., Yotsumoto, D., Takayama, S., Kaneko, K., Takahashi, M., Shimazu, K., Yoshidome, K., Kuraoka, K., Itakura, M., Tani, M., Ishikawa, T., Ohi, Y., Kinoshita, T., Sato, N., Tsujimoto, M., Nakamura, S., Tsuda, H., Noguchi, S., Akiyama, F.
- A prediction model for early systemic recurrence in breast cancer using a molecular diagnostic analysis of sentinel lymph nodes: A large-scale, multicenter cohort study.
Cancer, 128 (10): 1913-1920, 2022 - Shigematsu, Y., Amori, G., Kanda, H., Takahashi, Y., Takazawa, Y., Takeuchi, K., Inamura, K.
- Decreased ARG1 expression as an adverse prognostic phenotype in non-alcoholic non-virus-related hepatocellular carcinoma.
Virchows Arch., 481 (2): 253-263, 2022 - Shigematsu, Y., Nakano, K., Uchibori, K., Inamura, K.
- EGFR-mutated pulmonary choriocarcinoma combined with adenocarcinoma. J. Thorac. Oncol.: in press, 2022
- Shigematsu, Y., Kanda, H., Amori, G., Takahashi, Y., Takazawa, Y., Inamura, K.
- Nonalcoholic non-virus-related hepatocellular carcinoma arising from nonsteatotic liver: Clinical and pathological features.
Medicine (Baltimore), 101 (5): e28746, 2022 - Takamatsu, M., Yamamoto, N., Kawachi, H., Nakano, K., Saito, S., Fukunaga, Y., Takeuchi, K.
- Prediction of lymph node metastasis in early colorectal cancer based on histologic images by artificial intelligence.
Sci. Rep., 12 (1): 2963, 2022 - Takeuchi, K.
- Idiopathic plasmacytic lymphadenopathy: A conceptual history along with a translation of the original Japanese article published in 1980.
J. Clin. Exp. Hematop., 62 (2): 79-84, 2022 - Tsuyama, N., Noguchi, M., Asaka, R., Sakata, S., Baba, S., Izumi, H., Takeuchi, K.
- Hodgkinoid histiocytosis: An atypical nodal CD30 and S100-positive histiocytosis with eosinophilia.
Histopathology, 81 (3): 371-379, 2022 - Yamashita, K., Funauchi, Y., Hayakawa, K., Ae, K., Matsumoto, S., Ikuta, K., Nishida, Y., Ueno, T., Shimoyama, Y., Hiruta, N., Machinami, R., Kawachi, H., Takeuchi, K.
- S100-negative epithelioid malignant peripheral nerve sheath tumor with possible perineurial differentiation.
Virchows Arch., 480 (6): 1269-1275, 2022 - Inamura, K., Hamada, T., Bullman, S., Ugai, T., Yachida, S., Ogino, S.
- Cancer as microenvironmental, systemic and environmental diseases: opportunity for transdisciplinary microbiomics science.
Gut, 71 (10): 2107-2122, 2022 - Tonooka, A., Ohashi, R.
- Current trends of anti-cancer molecular targeted therapies: a narrative review focusing on renal complications and their histological features.
J. Nippon Med. Sch., 89 (2): 128-138, 2022 - Osako, T., Matsuura, M., Tsuda, H., Noguchi, S.
- Reply to "Survival analysis in a prediction model for early systemic recurrence in breast cancer".
Cancer, 128 (20): 3745-3746, 2022 - Sugawara, E., Koyama, K., Inamura, K.
- Molecular characterization of upper tract urothelial carcinoma for precision therapeutics and non-invasive diagnostics.
Curr. Genomics, 23 (1): 2-4, 2022
2021年
- Akiya, M., Osako, T., Morizono, H., Furuta, N., Kikuchi, M., Ueno, T., Ohno, S., Takeuchi, K.
- Myofibroblastoma of the breast showing rare palisaded morphology and uncommon desmin- and CD34-negative immunophenotype: A case report. Pathol. Int., 71 (8): 548-555, 2021
- Amori, G., Sugawara, E., Shigematsu, Y., Akiya, M., Kunieda, J., Yuasa, T., Yamamoto, S., Yonese, J., Takeuchi, K., Inamura, K.
- Tumor B7-H3 expression in diagnostic biopsy specimens and survival in patients with metastatic prostate cancer. Prostate Cancer Prostatic Dis., 24 (3): 767-774, 2021
- Horii, R., Nitta, H., Nojima, M., Maruyama, R., Ueno, T., Ito, Y., Ohno, S., Banks, P., Kanda, H., Akiyama, F.
- Predictive significance of HER2 intratumoral heterogeneity, determined by simultaneous gene and protein analysis, for resistance to trastuzumab-based treatments for HER2-positive breast cancer. Virchows Arch., 479 (1): 13-21, 2021
- Inamura, K.
- Adjuvant chemotherapy in patients with early-stage non-small cell lung cancer. JAMA Oncol., 7 (4): 637-638, 2021
- Maeshima, Y., Osako, T., Morizono, H., Yunokawa, M., Miyagi, Y., Kikuchi, M., Ueno, T., Ohno, S., Akiyama, F.
- Metastatic ovarian cancer spreading into mammary ducts mimicking an in situ component of primary breast cancer: A case report. J. Med. Case Rep., 15 (1): 78, 2021
- Saito, R., Ninomiya, H., Okumura, S., Mun, M., Sasano, H., Ishikawa, Y.
- Novel histologic classification of small tumor cell nests for lung adenocarcinoma with prognostic and etiological significance: Small solid nests and pure micropapillary nests. Am. J. Surg. Pathol., 45 (5): 604-615, 2021
- Sugiura, Y., Machinami, R., Matsumoto, S., Kanda, H., Ae, K., Takazawa, Y., Takeuchi, K.
- Prognostic value of CD34 expression status in patients with myxofibrosarcomas and undifferentiated pleomorphic sarcomas. Sci. Rep., 11 (1): 15494, 2021
- Tsugeno, Y., Kawachi, H., Kirimura, S., Hirota, Y., Shintaku, H., Ito, T., Kikuchi, A., Ohtsuka, K., Akashi, T., Kitagawa, M.
- Adenocarcinoma arising in the multiple heterotopic submucosal glands of the intestine in a Satoyoshi syndrome patient: A case report. Pathol. Int., 71 (2): 147-154, 2021
- Yamashita, K., Kohashi, K., Yamada, Y., Akatsuka, S., Ikuta, K., Nishida, Y., Toyokuni, S., Oda, Y.
- Prognostic significance of the MDM2/HMGA2 ratio and histological tumor grade in dedifferentiated liposarcoma. Genes Chromosomes Cancer, 60 (1): 26-37, 2021
- Inamura, K.
- Gut microbiota contributes towards immunomodulation against cancer: New frontiers in precision cancer therapeutics. Semin. Cancer Biol., 70: 11-23, 2021
- Osako, T.
- How can we better distinguish metastatic tumors from primary tumors in the breast? Expert Rev. Anticancer Ther., 21 (9): 913-916, 2021
2020年
- Ebina, A., Togashi, Y., Baba, S., Sato, Y., Sakata, S., Ishikawa, M., Mitani, H., Takeuchi, K. and Sugitani, I. (2020)
- TERT promoter mutation and extent of thyroidectomy in patients with 1-4 cm intrathyroidal papillary carcinoma. Cancers (Basel), 12: 2115
- Horii, R., Tsuda, H., Masuda, S., Sugita, H., Togashi, K., Ohno, S. and Akiyama, F. (2020)
- Performance analysis of the anti-Ki67 antibody clone 30-9 for immunohistochemical staining of breast cancer. Breast Cancer, 27: 1058-1064
- Inamura, K. (2020)
- Ethical Considerations about Genomic Medicine Implementation: Lessons Learned from the eMERGE III Study. Journal of personalized medicine, 10: E195
- Inamura, K. (2020)
- Gut microbiota contributes towards immunomodulation against cancer: New frontiers in precision cancer therapeutics. Semin. Cancer Biol.: in press
- Inamura, K. (2020)
- Roles of microbiota in response to cancer immunotherapy. Semin. Cancer Biol., 65: 164-175
- Ishii, S., Ito, T., Yamada, M., Yamazaki, N., Ikebata, K., Fujiyama, J., Furuta, N., Komatsu, K., Takeuchi, K., Sugiyama, Y. and Takazawa, Y. (2020)
- Characteristic cytological findings of lobular endocervical glandular hyperplasia associated with adenocarcinoma of the uterine cervix. Acta Cytol., 64: 556-562
- Luangxay, T., Osako, T., Yonekura, R., Sugiura, Y., Kikuchi, M., Gomi, N., Ueno, T., Ohno, S., Machinami, R., Takeuchi, K. and Akiyama, F. (2020)
- Giant cell tumor of soft tissue of the breast: Case report with H3F3A mutation analysis and review of the literature. Pathol. Res. Pract., 216: 152750
- Naito, K., Shigematsu, Y., Fujiwara, Y., Inamura, K., Togashi, Y., Inoue, Y., Takazawa, Y., Kanda, H. and Matsueda, K. (2020)
- Identification of a specific ultrasonographic finding for differentiating hepatic angiomyolipoma from hepatocellular carcinoma. Clin. Imag., 59: 104-108
- Nakashima, Y., Inamura, K., Ninomiya, H., Okumura, S., Mun, M., Kirimura, S., Kobayashi, M., Okubo, K. and Ishikawa, Y. (2020)
- Frequent expression of conventional endothelial markers in pleural mesothelioma: Usefulness of claudin-5 as well as combined traditional markers to distinguish mesothelioma from angiosarcoma. Lung Cancer, 148: 20-27
- Omi, M., Tonooka, A., Chiba, T., Tanaka, Y., Fusegi, A., Aoki, Y., Nomura, H., Kanao, H. and Takazawa, Y. (2020)
- Immunohistochemical markers and the clinical course of adenosarcoma: a series of seven cases. Diagn. Pathol., 15: 119
- Osako, T., Lee, H., Turashvili, G., Chiu, D. Y., McKinney, S., Joosten, S. E. P., Wilkinson, D. S., Nielsen, T. O., Zwart, W., Emerman, J. T., Eaves, C. J., Caldas, C. and Aparicio, S. (2020)
- Age-correlated protein and transcript expression in breast cancer and normal breast tissues is dominated by host endocrine effects. Nature Cancer, 1: 518-532
- Sakamoto, K. and Takeuchi, K. (2020)
- Cytogenetics of blastic plasmacytoid dendritic cell neoplasm: Chromosomal rearrangements and DNA copy-number alterations. Hematol. Oncol .Clin .North Am., 34: 523-538
- Shigematsu, Y., Yamashita, K., Takamatsu, M., Tanizawa, T., Togashi, Y., Nakajima, T., Chino, A., Kawachi, H. and Takeuchi, K. (2020)
- Primary intramucosal synovial sarcoma of the sigmoid colon in a patient with a germline mutation in the MSH2 gene: A case report. Pathol. Int., 70: 1015-1019
- Tsugeno, Y., Nakano, K., Nakajima, T., Namikawa, K., Takamatsu, M., Yamamoto, N., Fujisaki, J., Nunobe, S., Kitagawa, M., Takeuchi, K. and Kawachi, H. (2020)
- Histopathologic analysis of signet-ring cell carcinoma in situ in patients with hereditary diffuse gastric cancer. Am. J. Surg. Pathol., 44: 1204-1212
- Wakejima, R., Inamura, K., Ninomiya, H., Nagano, H., Mun, M., Okumura, S., Okubo, K. and Ishikawa, Y. (2020)
- Mucinous lung adenocarcinoma, particularly referring to EGFR-mutated mucinous adenocarcinoma. Pathol. Int., 70: 72-83
- Yamamoto, T., Gulanbar, A., Hayashi, K., Kohno, A., Komai, Y., Yonese, J., Matsueda, K. and Inamura, K. (2020)
- Is hypervascular papillary renal cell carcinoma present? Abdom. Radiol.: in press
- Yoshimizu, S., Kawachi, H., Yamamoto, Y., Nakano, K., Horiuchi, Y., Ishiyama, A., Tsuchida, T., Yoshio, T., Hirasawa, T., Ito, H. and Fujisaki, J. (2020)
- Clinicopathological features and risk factors for lymph node metastasis in early-stage non-ampullary duodenal adenocarcinoma. J. Gastroenterol., 55: 754-762
2019年
- Chang, K. C., Yu-Yun Lee, J., Sakamoto, K., Baba, S. and Takeuchi, K. (2019)
- Blastic plasmacytoid dendritic cell neoplasm with immunoblastoid morphology and MYC rearrangement and overexpression. Pathology, 51: 100-102
- Hashimoto, H., Tsugeno, Y., Sugita, K. and Inamura, K. (2019)
- Mesenchymal tumors of the lung: diagnostic pathology, molecular pathogenesis, and identified biomarkers. J. Thorac. Dis., 11: S9-S24
- Hashimoto, H., Usui, G., Tsugeno, Y., Sugita, K., Amori, G., Morikawa, T. and Inamura, K. (2019)
- Cerebral thromboembolism after lobectomy for lung cancer: Pathological diagnosis and mechanism of thrombus formation. Cancers (Basel), 11: E-488
- Inamura, K., Amori, G., Yuasa, T., Yamamoto, S., Yonese, J. and Ishikawa, Y. (2019)
- Relationship of B7-H3 expression in tumor cells and tumor vasculature with FOXP3+ regulatory T cells in renal cell carcinoma. Cancer Manag. Res., 11: 7021-7030
- Ishioka, M., Hirasawa, T., Kawachi, H., Nakano, K., Kunieda, J., Yoshimizu, S., Horiuchi, Y., Ishiyama, A., Yoshio, T., Tsuchida, T. and Fujisaki, J. (2019)
- Enterochromaffin-like cell neuroendocrine tumor associated with parietal cell dysfunction. Gastrointest. Endosc., 90: 841-845.e841
- Kawachi, H. (2019)
- Histopathological diagnosis of ulcerative colitis-associated neoplasia. Dig. Endosc., 31 Suppl 1: 31-35
- Kobayashi, M., Kawachi, H., Pasternak, S., Delgado, C., Pinto, P., Ito, T., Karelovic, S., Carrasco, H., Tanaka, K., Okada, T., Odagaki, T., Zarate, A. J., Ponce, A., Kronberg, U., Lopez-Kostner, F., Tsubaki, M., Kawano, T. and Eishi, Y. (2019)
- Histopathologic study from a colorectal cancer screening in Chile: results from the first 2 years of an international collaboration between Chile and Japan. Eur. J. Cancer Prev., 28: 245-253
- Matsue, K., Abe, Y., Narita, K., Kobayashi, H., Kitadate, A., Takeuchi, M., Miura, D. and Takeuchi, K. (2019)
- Diagnosis of intravascular large B-cell lymphoma: novel insights into clinicopathological features from 42 patients at a single institution over 20 years. Br. J. Haematol., 187: 328-336
- Osumi, H., Kawachi, H., Murai, K., Kusafuka, K., Inoue, S., Kitamura, M., Yoshio, T., Kakusima, N., Ishihara, R., Ono, H., Yamamoto, N., Sugino, T., Nakatsuka, S., Ida, S., Nunobe, S., Bando, E., Omori, T., Takeuchi, K. and Fujisaki, J. (2019)
- Risk stratification for lymph node metastasis using Epstein-Barr virus status in submucosal invasive (pT1) gastric cancer without lymphovascular invasion: a multicenter observational study. Gastric Cancer, 22: 1176-1182
- Osumi, H., Kawachi, H., Yoshio, T., Ida, S., Yamamoto, N., Horiuchi, Y., Ishiyama, A., Hirasawa, T., Tsuchida, T., Hiki, N., Takeuchi, K. and Fujisaki, J. (2019)
- Epstein-Barr virus status is a promising biomarker for endoscopic resection in early gastric cancer: proposal of a novel therapeutic strategy. J. Gastroenterol., 54: 774-783
- Takamatsu, M., Kawachi, H., Yamamoto, N., Kobayashi, M., Toyama, Y., Maekawa, T., Chino, A., Saito, S., Ueno, M., Takazawa, Y. and Ishikawa, Y. (2019) Immunohistochemical evaluation of tumor budding for stratifying
- T1 colorectal cancer: optimal cut-off value and a novel computer-assisted semiautomatic method. Mod. Pathol., 32: 675-683
- Takamatsu, M., Yamamoto, N., Kawachi, H., Chino, A., Saito, S., Ueno, M., Ishikawa, Y., Takazawa, Y. and Takeuchi, K. (2019)
- Prediction of early colorectal cancer metastasis by machine learning using digital slide images. Comput. Methods Programs Biomed., 178: 155-161
- Takeuchi, K. (2019)
- Discovery stories of RET fusions in lung cancer: A mini-review. Front. Physiol., 10: 216
- Tsuyama, N., Yokoyama, M., Fujisaki, J., Oguchi, M., Terui, Y. and Takeuchi, K. (2019)
- Villous colonization (glove balloon sign): A histopathological diagnostic marker for follicular lymphomas with duodenal involvement including duodenal-type follicular lymphoma. Pathol. Int., 69: 48-50
- Yamamoto, T., Koizumi, M., Kohno, A., Numao, N. and Inamura, K. (2019)
- A case report on 111In chloride bone marrow scintigraphy in management of adrenal myelolipoma. Medicine (Baltimore), 98: e14625
- Yonekura, R., Horii, R., Iwase, T., Gomi, N., Kitagawa, M., Akiyama, F. and Ohno, S. (2019)
- A diagnostic strategy for breast calcifications based on a long-term follow-up of 615 lesions. Jpn. J. Radiol., 37: 237-244
- Yonekura R, Osako T, Iwase T, Ogiya A, Ueno T, Kitagawa M, et al.
- Prognostic impact and possible pathogenesis of lymph node metastasis in ductal carcinoma in situ of the breast. Breast Cancer Res Treat. 2019;174(1):103-11.
2018年
- Dobashi, A., Togashi, Y., Tanaka, N., Yokoyama, M., Tsuyama, N., Baba, S., Mori, S., Hatake, K., Yamaguchi, T., Noda, T. and Takeuchi, K. (2018)
- TP53 and OSBPL10 alterations in diffuse large B-cell lymphoma: prognostic markers identified via exome analysis of cases with extreme prognosis. Oncotarget, 9: 19555-19568
- Inamura, K. (2018)
- Bladder cancer: New insights into its molecular pathology. Cancers (Basel), 10: pii: E100
- Inamura, K. (2018)
- Clinicopathological characteristics and mutations driving development of early lung Adenocarcinoma: tumor initiation and progression. Int. J. Mol. Sci., 19: pii: E1259
- Inamura, K. (2018)
- Prostatic cancers: understanding their molecular pathology and the 2016 WHO classification. Oncotarget, 9: 14723-14737
- Inamura, K. (2018)
- Update on immunohistochemistry for thedDiagnosis of lung cancer. Cancers (Basel), 10: pii: E72
- Inamura, K., Shigematsu, Y., Ninomiya, H., Nakashima, Y., Kobayashi, M., Saito, H., Takahashi, K., Futaya, E., Okumura, S., Ishikawa, Y. and Kanda, H. (2018)
- CSF1R-expressing tumor-associated macrophages, smoking and survival in lung adenocarcinoma: Analyses using quantitative phosphor-integrated dot staining. Cancers (Basel), 10: E252
- Inamura, K., Takazawa, Y., Inoue, Y., Yokouchi, Y., Kobayashi, M., Saiura, A., Shibutani, T. and Ishikawa, Y. (2018)
- Tumor B7-H3 (CD276) expression and survival in pancreatic cancer. J. Clin. Med., 7: 172
- Inoue, H., Horii, R., Ito, Y., Iwase, T., Ohno, S. and Akiyama, F. (2018)
- Tumor-infiltrating lymphocytes affect the efficacy of trastuzumab-based treatment in human epidermal growth factor receptor 2-positive breast cancer. Breast Cancer, 25: 268-274
- Kanda, H., Furuta, N., Takazawa, Y., Furuta, R., Ae, K., Sugiyama, Y. and Ishikawa, Y. (2018)
- Cytological findings of gastrointestinal stromal tumor-derived bone metastasis. Acta Cytol., 62: 430-435
- Noma, D., Inamura, K., Matsuura, Y., Hirata, Y., Nakajima, T., Yamazaki, H., Hirai, Y., Ichinose, J., Nakao, M., Ninomiya, H., Mun, M., Nakagawa, K., Masuda, M., Ishikawa, Y. and Okumura, S. (2018)
- Prognostic effect of lymphovascular invasion on TNM staging in stage I non-small-cell lung cancer. Clin. Lung Cancer, 19: e109-e122
- Sakamoto, K., Katayama, R., Asaka, R., Sakata, S., Baba, S., Nakasone, H., Koike, S., Tsuyama, N., Dobashi, A., Sasaki, M., Ichinohasama, R., Takakuwa, E., Yamazaki, R., Takizawa, J., Maeda, T., Narita, M., Izutsu, K., Kanda, Y., Ohshima, K. and Takeuchi, K. (2018)
- Recurrent 8q24 rearrangement in blastic plasmacytoid dendritic cell neoplasm: association with immunoblastoid cytomorphology, MYC expression, and drug response. Leukemia, 32: 2590-2603
- Shigematsu, Y. and Inamura, K. (2018)
- Gut microbiome: a key player in cancer immunotherapy. Hepatobiliary Surg. Nutr., 7: 479-480
- Shigematsu, Y., Inamura, K., Mise, Y., Saiura, A., Rehnberg, E., Yamamoto, N., Ishikawa, Y., Takahashi, S. and Kanda, H. (2018)
- CDX2 expression is concordant between primary colorectal cancer lesions and corresponding liver metastases independent of chemotherapy: a single-center retrospective study in Japan. Oncotarget, 9: 17056-17065
- Shigematsu, Y., Inamura, K., Yamamoto, N., Mise, Y., Saiura, A., Ishikawa, Y., Takahashi, S. and Kanda, H. (2018)
- Impact of CDX2 expression status on the survival of patients after curative resection for colorectal cancer liver metastasis. BMC Cancer, 18: 980
- Shigematsu, Y., Kanda, H., Nagasaki, T., Inoue, Y. and Takahashi, S. (2018)
- Hepatic eosinophilic abscesses associated with sigmoid colon cancer Intern. Med., 57: 1405-1409
- Subat, S., Inamura, K., Ninomiya, H., Nagano, H., Okumura, S. and Ishikawa, Y. (2018)
- Unique MicroRNA and mRNA Interactions in EGFR-Mutated Lung Adenocarcinoma. J. Clin. Med., 7: 419
- Takamatsu, M., Sato, Y., Muto, M., Nagano, H., Ninomiya, H., Sakakibara, R., Baba, S., Sakata, S., Takeuchi, K., Okumura, S. and Ishikawa, Y. (2018)
- Hyalinizing clear cell carcinoma of the bronchial glands: presentation of three cases and pathological comparisons with salivary gland counterparts and bronchial mucoepidermoid carcinomas. Mod. Pathol., 31: 923-933
- Togashi, Y., Dobashi, A., Sakata, S., Sato, Y., Baba, S., Seto, A., Mitani, H., Kawabata, K. and Takeuchi, K. (2018)
- MYB and MYBL1 in adenoid cystic carcinoma: diversity in the mode of genomic rearrangement and transcripts. Mod. Pathol., 31: 934-946
- Tsuyama, N., Asaka, R., Dobashi, A., Baba, S., Mishima, Y., Ueda, K., Oguchi, M., Tsuji, H., Hatake, K. and Takeuchi, K. (2018)
- Epstein-Barr virus-negative extranodal “true” natural killer-cell lymphoma harbouring a KDM6A mutation. Hematol. Oncol., 36: 328-335
- Yamazaki, K., Horii, R., Iwase, T., Ueno, T., Ohno, S. and Akiyama, F. (2018)
- Ductal carcinoma in situ manageable by active surveillance. Ann. Breast Cancer Res., 3: 1-4
2017年
- Inamura, K. (2017)
- Diagnostic and therapeutic potential of microRNAs in lung cancer. Cancers (Basel), 9: pii: E49.
- Inamura, K. (2017)
- Lung cancer: Understanding its molecular pathology and the 2015 WHO classification. Front. Oncol., 7: 193
- Inamura, K. (2017)
- Major tumor suppressor and oncogenic non-coding RNAs: Clinical relevance in lung cancer. Cells, 6: 12
- Inamura, K. (2017)
- Renal cell tumors: Understanding their molecular pathological epidemiology and the 2016 WHO classification. Int. J. Mol. Sci., 18: pii: E2195
- Inamura, K. (2017)
- Translocation renal cell carcinoma: An update on clinicopathological and molecular features. Cancers (Basel), 9: pii: E111
- Inamura, K., Kobayashi, M., Nagano, H., Sugiura, Y., Ogawa, M., Masuda, H., Yonese, J. and Ishikawa, Y. (2017)
- A novel fusion of HNRNPA1-ALK in inflammatory myofibroblastic tumor of urinary bladder. Hum. Pathol., 69: 96-100
- Inamura, K., Yokouchi, Y., Kobayashi, M., Ninomiya, H., Sakakibara, R., Nishio, M., Okumura, S. and Ishikawa, Y. (2017)
- Relationship of tumor PD-L1 (CD274) expression with lower mortality in lung high-grade neuroendocrine tumor. Cancer Med., 6: 2347-2356
- Inamura, K., Yokouchi, Y., Kobayashi, M., Ninomiya, H., Sakakibara, R., Subat, S., Nagano, H., Nomura, K., Okumura, S., Sibutani, T. and Ishikawa, Y. (2017)
- Association of tumor TROP2 expression with prognosis varies among lung cancer subtypes. Oncotarget, 8: 28725-28735
- Inamura, K., Yokouchi, Y., Kobayashi, M., Sakakibara, R., Ninomiya, H., Subat, S., Nagano, H., Nomura, K., Okumura, S., Shibutani, T. and Ishikawa, Y. (2017) T
- umor B7-H3 (CD276) expression and smoking history in relation to lung adenocarcinoma prognosis. Lung Cancer, 103: 44-51
- Muto, M., Inamura, K., Ozawa, N., Endo, T., Masuda, H., Yonese, J. and Ishikawa, Y. (2017)
- Skene's gland adenocarcinoma with intestinal differentiation: A case report and literature review. Pathol. Int., 67: 575-579
- Osako, T., Iwase, T., Ushijima, M., Yonekura, R., Ohno, S. and Akiyama, F. (2017)
- A new molecular-based lymph node staging classification determines the prognosis of breast cancer patients. Br. J. Cancer., 117: 1470-1477
- Sakakibara, R., Inamura, K., Tambo, Y., Ninomiya, H., Kitazono, S., Yanagitani, N., Horiike, A., Ohyanagi, F., Matsuura, Y., Nakao, M., Mun, M., Okumura, S., Inase, N., Nishio, M., Motoi, N. and Ishikawa, Y. (2017)
- EBUS-TBNA as a promising method for the evaluation of tumor PD-L1 expression in lung cancer. Clin. Lung Cancer, 18: 527-534
- Shigematsu, Y., Kanda, H., Konishi, T., Takazawa, Y., Inoue, Y., Muto, T., Ishikawa, Y. and Takahashi, S. (2017)
- Recurrence 30 years after surgical resection of localized rectal neuroendocrine tumor. Intern. Med., 56: 1521-1525
- Tsuyama, N., Ennishi, D., Yokoyama, M., Baba, S., Asaka, R., Mishima, Y., Terui, Y., Hatake, K. and Takeuchi, K. (2017)
- Clinical and prognostic significance of aberrant T-cell marker expression in 225 cases of de novo diffuse large B-cell lymphoma and 276 cases of other B-cell lymphomas. Oncotarget, 8: 33487-33500
- Tsuyama, N., Sakamoto, K., Sakata, S., Dobashi, A. and Takeuchi, K. (2017)
- Anaplastic large cell lymphoma: pathology, genetics, and clinical aspects. J. Clin. Exp. Hematop., 57: 120-142
- Tsuyama, N., Sakata, S., Baba, S., Mishima, Y., Nishimura, N., Ueda, K., Yokoyama, M., Terui, Y., Hatake, K., Kitagawa, M., Ishizuka, N., Tomita, N. and Takeuchi, K. (2017)
- BCL2 expression in DLBCL: reappraisal of immunohistochemistry with new criteria for therapeutic biomarker evaluation. Blood, 130: 489-500
2016年
- Dobashi, A., Tsuyama, N., Asaka, R., Togashi, Y., Ueda, K., Sakata, S., Baba, S., Sakamoto, K., Hatake, K. and Takeuchi, K. (2016)
- Frequent BCOR aberrations in extranodal NK/T-Cell lymphoma, nasal type. Genes Chromosomes Cancer, 55: 460-471
- Horii, R. and Akiyama, F. (2016)
- Histological assessment of therapeutic response in breast cancer. Breast Cancer, 23: 540-545
- Horii, R., Honma, N., Ogiya, A., Kozuka, Y., Yoshida, K., Yoshida, M., Horiguchi, S. I., Ito, Y. and Mukai, H. (2016)
- The Japanese Breast Cancer Society clinical practice guidelines for pathological diagnosis of breast cancer, 2015 edition. Breast Cancer, 23: 391-399
- Inamura, K. and Ishikawa, Y. (2016)
- MicroRNA In lung cancer: Novel biomarkers and potential tools for treatment. J. Clin. Med., 5: pii: E36
- Inamura, K., Yokouchi, Y., Sakakibara, R., Kobayashi, M., Subat, S., Ninomiya, H., Nagano, H., Nomura, K., Okumura, S. and Ishikawa, Y. (2016)
- Relationship of tumor PD-L1 expression with EGFR wild-type status and poor prognosis in lung adenocarcinoma. Jpn. J. Clin. Oncol., 46: 935-941
- Kanda, H., Furuta, R., Motoi, N., Suzuki, N., Furuta, N., Komatsu, K., Sugiyama, Y., Saiura, A., Sugitani, M. and Ishikawa, Y. (2016)
- Touch cytology smear of an inflammatory hepatocellular adenoma displaying an unusual pattern: A case report. Diagn. Cytopathol., 44: 1074-1077
- Kobayashi, K., Horii, R., Ito, Y., Ohno, S., Iwase, T. and Akiyama, F. (2016)
- Prognostic significance of histological therapeutic effect in preoperative chemotherapy for breast cancer. Pathol. Int., 66: 8-14
- Nakagawa, T., Horii, R., Ito, Y., Iwase, T. and Akiyama, F. (2016)
- Development of an easy method to test for HER2 in breast cancer using dual-color in situ hybridization. Breast Cancer, 23: 78-84
- Noma, D., Inamura, K., Mun, M., Terauchi, T., Matsuura, Y., Nakao, M., Ninomiya, H., Nakagawa, K., Masuda, M., Okumura, S. and Ishikawa, Y. (2016)
- Thymic oncocytic carcinoid with a markedly elevated level of maximum SUV. Pathol. Int., 66: 593-595
- Sakamoto, K., Nakasone, H., Togashi, Y., Sakata, S., Tsuyama, N., Baba, S., Dobashi, A., Asaka, R., Tsai, C. C., Chuang, S. S., Izutsu, K., Kanda, Y. and Takeuchi, K. (2016)
- ALK-positive large B-cell lymphoma: identification of EML4-ALK and a review of the literature focusing on the ALK immunohistochemical staining pattern. Int. J. Hematol., 103: 399-408
- Shigematsu, Y., Araki, K., Horii, R., Akiyama, F., Takahashi, S., Ohno, S. and Itoh, Y. (2016)
- Aggressive recurrence of early breast invasive ductal carcinoma with gastric metastasis during adjuvant hormonal therapy. Case Rep. Clin. Pathol., 3: 1-6
- Shigematsu, Y., Matsuura, M., Nishimura, N., Tsuyama, N., Takeuchi, K., Terui, Y., Takeshima, N. and Hatake, K. (2016)
- Intravascular large B-cell lymphoma of bilateral ovaries and the uterus in an asymptomatic patient with a t(11;22)(q23;q11) constitutional translocation. Intern. Med., 55: 3169-3174
- Takeuchi, K., Togashi, Y., Kamihara, Y., Fukuyama, T., Yoshioka, H., Inoue, A., Katsuki, H., Kiura, K., Nakagawa, K., Seto, T., Maemondo, M., Hida, T., Harada, M., Ohe, Y., Nogami, N., Yamamoto, N., Nishio, M. and Tamura, T. (2016)
- Prospective and clinical validation of ALK immunohistochemistry: Results from the phase I/II study of alectinib for ALK-positive lung cancer (AF-001JP study). Ann. Oncol., 27: 185-192
連絡先
竹内 賢吾(部長)
〒135-8550 江東区有明3-8-31