第62回がん研先端研究セミナー(2月10日)のお知らせ

演題：The transcriptional regulation of intestinal stem cell regeneration

演者：村田 和貴 博士（Dana-Farber Cancer Institute (Dr. Ramesh A. Shivdasani lab) / 現所属　理化学研究所バトンゾーン研究推進プログラム横山特別研究室)

抄録：The intestinal epithelium is the constantly renewing tissue which has a great plasticity to adapt to different types of damage. Lgr5⁺ crypt base columnar cells are intestinal stem cells (ISCs) to maintain the tissue homeostasis. Ablation of ISCs is associated with rapid restoration of the ISC compartment. Different intestinal crypt populations dedifferentiate to provide new ISCs, but the transcriptional and signaling trajectories that guide this process are unclear. The ISC-restricted transcription factor ASCL2 confers measurable competitive advantage to resting ISCs and is essential to restore the ISC compartment. Regenerating cells re-express Ascl2 days before Lgr5 expression and an ASCL2 target gene enhances stem cell regenerative potential. These findings reveal cell dedifferentiation as the principal means for ISC restoration and highlight an ASCL2-regulated signal that enables this adaptive response.

Murata K et al. Ablated intestinal stem cells recover predominantly by ASCL2-dependent dedifferentiation of their recent progeny. Cell Stem Cell. In press.

日時：２０２０年２月１０日（月）１６：００〜１７：００

場所：がん研究所　吉田講堂

連絡先：丸山玲緒（内線5441）

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