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2020年

2020年12月28日
Campisi, M., Sundararaman, S. K., Shelton, S. E., Knelson, E. H., Mahadevan, N. R., Yoshida, R., Tani, T., Ivanova, E., Cañadas, I., Osaki, T., Lee, S. W. L., Thai, T., Han, S., Piel, B. P., Gilhooley, S., Paweletz, C. P., Chiono, V., Kamm, R. D., Kitajima, S. and Barbie, D. A.
Tumor-derived cGAMP regulates activation of the vasculature.
Front. Immunol., 11, 2090 (2020)
2020年12月28日
Kitajima, S., Li, F. and Takahashi, C.
Tumor milieu controlled by RB tumor suppressor.
Int. J. Mol. Sci., 21, 2450 (2020)
2020年12月28日
Sehgal, K., Portell, A. J., Ivanova, E. V., Lizotte, P. H., Mahadevan, N. R., Greene, J. R., Vajdi, A., Gurjao, C., Teceno, T., Taus, L. J., Thai, T. C., Kitajima, S., Liu, D., Tani, T., Noureddine, M., Lau, C. J., Kirschmeier, P. T., Liu, D., Giannakis, M., Jenkins, R. W., Gokhale, P. C., Goldoni, S., Pinzon-Ortiz, M., Hastings, W. D., Hammerman, P., Miret, J. J., Paweletz, C. P. and Barbie, D. A.
Dynamic single-cell RNA sequencing identifies immunotherapy persister cells following PD-1 blockade.
J. Clin. Invest., in press (2020)
2020年12月21日
Osumi, H., Muroi, A., Sakahara, M., Kawachi, H., Okamoto, T., Natsume, Y., Yamanaka, H., Takano, H., Kusama, D., Shinozaki, E., Ooki, A., Yamaguchi, K., Ueno, M., Takeuchi, K., Noda, T., Nagayama, S., Koshikawa, N. and Yao, R.
Evaluation of the RAS signaling network in response to MEK inhibition using organoids derived from a familial adenomatous polyposis patient.
Sci. Rep., 10, 17455 (2020)
2020年12月7日
Gotoh, O., Kiyotani, K., Chiba, T., Sugiyama, Y., Takazawa, Y., Nemoto, K., Kato, K., Tanaka, N., Nomura, H., Hasegawa, K., Fujiwara, K., Takamatsu, S., Matsumura, N., Noda, T. and Mori, S.
Immunogenomic Landscape of Gynecologic Carcinosarcoma.
Gynecol. Oncol., in press (2020)
2020年12月3日
Furuta, H., Araki, M., Masago, K., Sagae, Y., Fujita, S., Seto, K., Shimizu, J., Horio, Y., Sasaki, E., Hosoda, W., Katayama, R., Okuno, Y. and Hida, T.
Novel resistance mechanisms including L1196Q, P1094H, and R1248_D1249insertion in three patients with non-small-cell lung cancer following ALK tyrosine kinase inhibitor treatment.
J. Thorac. Oncol., in press (2020)
2020年12月3日
Ariyasu, R., Yanagitani, N., Tadokoro, K., Yamaguchi, T., Uchibori, K., Kitazono, S., Fujita, N., Katayama, R. and Nishio, M.
Efficacy of EGFR tyrosine kinase inhibitors in patients having EGFR-activating mutations with or without BIM polymorphisms.
Cancer Chemother. Pharmacol., 86, 517-525 (2020)
2020年10月12日
Kato, Y., Kunimasa, K., Takahashi, M., Harada, A., Nagasawa, I., Osawa, M., Sugimoto, Y. and Tomida, A.
GZD824 inhibits GCN2 and sensitizes cancer cells to amino acid starvation stress.
Molecular Pharmacology, in press (2020)
2020年10月6日
Nosol, K., Romane, K., Irobalieva, R. N., Alam, A., Kowal, J., Fujita, N. and Locher, K. P.
Cryo-EM structures reveal distinct mechanisms of inhibition of the human multidrug transporter ABCB1.
Proc. Natl. Acad. Sci. U. S. A., in press (2020)
2020年10月5日
Sonoda, T., Yanagitani, N., Suga, K., Yoshizawa, T., Nishikawa, S., Kitazono, S., Horiike, A., Shiba, K., Ishizuka, T., Nishio, M. and Matsusaka, S.
A novel system to detect circulating tumor cells using two different size-selective microfilters.
Anticancer Res., 40, 5577-5582 (2020)
2020年9月3日
Akiyoshi, T., Gotoh, O., Tanaka, N., Kiyotani, K., Yamamoto, N., Ueno, M., Fukunaga, Y. and Mori, S.
T-cell complexity and density are associated with sensitivity to neoadjuvant chemoradiotherapy in patients with rectal cancer.
Cancer Immunol. Immunother., in press (2020)
2020年7月22日
Nozawa, R. S., Yamamoto, T., Takahashi, M., Tachiwana, H., Maruyama, R., Hirota, T. and Saitoh, N.
Nuclear microenvironment in cancer: control through liquid-liquid phase separation.
Cancer Sci., in press (2020)
2020年7月13日
Nitta, N., Iino, T., Isozaki, A., Yamagishi, M., Kitahama, Y., Sakuma, S., Suzuki, Y., Tezuka, H., Oikawa, M., Arai, F., Asai, T., Deng, D., Fukuzawa, H., Hase, M., Hasunuma, T., Hayakawa, T., Hirai, K., Hiramatsu, K., Hoshino, Y., Inaba, M., Inoue, Y., Ito, T., Karakawa, H., Kasai, Y., Kato, Y., Kobayashi, H., Lei, C., Matsusaka, S., Mikami, H., Nakagawa, A., Numata, k., Ota, T., Sekiya, T., Shiba, K., Shirasaki, Y., Suzuki, N., Tanaka, S., Ueno, S., Watarai, H., Yamano, T., Yazawa, M., Yonamine, Y., Carlo, D. D., Hosokawa, Y., Uemura, S., Sugimura, T., Ozeki, Y. and Goda, K.
Raman image-activated cell sorting.
Naure Communications, 11, 3452 (2020)
2020年6月29日
Papadopoulos, K. P., Borazanci, E., Shaw, A. T., katayama, R., Shimizu, Y., Zhu, V. W., sun, T. Y., Wakelee, H. A., Madison, R., Schrock, A. B., Senaldi, G., Nakao, N., Hanzawa, H., Tachibana, M., Isoyama, T., Nakamaru, K., Deng, C., Li, M., Fran, F., Zhao, O., Gao, Y., Seto, T., Janne, P. A. and Ou, S. H. I.
US phase 1 first-in-human study of taletrectinib (DS-6051b/AB-106), a ROS1/TRK inhibitor, in patients with advanced solid tumors.
Clin. Cancer Res., in press (2020)
2020年6月26日
Arai, S., Takeuchi, S., Fukuda, K., Taniguchi, H., Nishiyama, A., Tanimoto, A., Satouchi, M., Yamashita, K., Ohtsubo, K., Nanjo, S., Kumagai, T., Katayama, R., Nishio, M., Zheng, M. M., Wu, Y. L., Nishihara, H., Yamamoto, T., Nakada, M. and Yano, S.
Osimertinib overcomes alectinib resistance caused by amphiregulin in a leptomeningeal carcinomatosis model of ALK-rearranged lung cancer.
J. Thorac. Oncol., 15, 752-765 (2020)
2020年6月26日
Ono, F., Chiba, S., Isaka, Y., Matsumoto, S., Ma, B., Katayama, R., Araki, M. and Okuno, Y.
Improvement in predicting drug sensitivity changes associated with protein mutations using a molecular dynamics based alchemical mutation method.
Sci. Rep., 10, 2161 (2020)
2020年6月26日
Yanagitani, N., Uchibori, K., Koike, S., Tsukahara, M., Kitazono, S., Yoshizawa, T., Horiike, A., Ohyanagi, F., Tambo, Y., Nishikawa, S., Fujita, N., Katayama, R. and Nishio, M.
Drug resistance mechanisms in Japanese ALK positive NSCLC and the clinical responses based on the resistant mechanisms.
Cancer Sci., 111, 932-939 (2020)
2020年6月22日
Fujimura, A., Hayashi, Y., Kato, K., Kogure, Y., Kameyama, M., Shimamoto, H., Daitoku, H., Fukamizu, A., Hirota, T. and Kimura, K.
Identification of a novel nucleolar protein complex required for mitotic chromosome segregation through centromeric accumulation of Aurora B.
Nucleic Acids Res., in press (2020)
2020年6月15日
Kaneyasu, T., Mori, S., Yamauchi, H., Ohsumi, S., Ohno, S., Aoki, D., Baba, S., Kawano, J., Miki, Y., Matsumoto, N., Nagasaki, M., Yoshida, R., Akashi-Tanaka, S., Iwase, T., Kitagawa, D., Masuda, K., hirasawa, A., Arai, M., Takei, J., Ide, Y., Gotoh, O., Yaguchi, N., Nishi, M., Kaneko, K., Matsuyama, Y., Okawa, M., Suzuki, M., Nezu, A., Yokoyama, S., Amino, S., Inuzuka, M., Noda, T. and Nakamura, S.
Prevalence of disease-causing genes in Japanese patients with BRCA1/2-wildtype hereditary breast and ovarian cancer syndrome.
NPJ Breast Cancer, in press (2020)
2020年6月2日
Oka, M., Kobayashi, N., Matsumura, K., Nishio, M., Nakano, K., Okamura, T., Okochi, H., Minamisawa, T., Shiba, K. and Saeki, K.
New role for growth/differentiation factor 15 in the survival of transplanted brown adipose tissues in cooperation with interleukin-6.
Cells, in press (2020)
2020年5月26日
Misawa, T., Tanaka, Y., Okada, R. and Takahashi, A.
Biology of extracellular vesicles secreted from senescent cells as senescence-associated secretory phenotype factors.
Geriatr. Gerontol. Int., in press (2020)
2020年5月26日
Sakamoto, K. and Takeuchi, K.
Cytogenetics of blastic plasmacytoid dendritic cell neoplasm: Chromosomal rearrangements and DNA copy-number alterations.
Hematology/oncology clinics of North America, 34, 523-538 (2020)
2020年5月26日
Osako, T., Lee, H., Turashvili, G., Chiu, D. Y., McKinney, S., Joosten, S. E. P., Wilkinson, D. S., Nielsen, T. O., Zwart, W., Emerman, J. T., Eaves, C. J., Caldas, C. and Aparicio, S.
Age-correlated protein and transcript expression in breast cancer and normal breast tissues is dominated by host endocrine effects.
Nature Cancer, in press (2020)
2020年5月26日
Hitomi, K., Okada, R., Loo, T. M., Miyata, K., Nakamura, A. J. and Takahashi, A.
DNA damage regulates senescence-associated extracellular vesicle release via the ceramide pathway to prevent excessive inflammatory responses.
Int. J. Mol. Sci., 21, 3720 (2020)
2020年5月8日
Tachiwana, H., Yamamoto, T. and Saitoh, N.
Gene regulation by non-coding RNAs in the 3D genome architecture.
Current Opinion in Genetics & Development, 61, 69-74 (2020)
2020年5月8日
Wakita, M., Takahashi, A., Sano, O., Loo, T. M., Imai, Y., Narukawa, M., Iwata, H., Matsudaira, T., Kawamoto, S., Ohtani, N., Yoshimori, T. and Hara, E.
A BET family protein degrader provokes senolysis by targeting NHEJ and autophagy in senescent cells.
Nat. Commun., 11, 1935 (2020)
2020年4月2日
Nagasawa, I., Koido, M., Tani, Y., Tsukahara, S., Kunimasa, K. and Tomida, A.
Disrupting ATF4 expression mechanisms provides an effective strategy for BRAF-targeted melanoma therapy.
iScience, in press (2020)
2020年3月3日
Okamoto, Y., Saito, T., Tani, Y., Toki, T., Hasebe, A., Koido, M. and Tomida, A.
The kinase PERK represses translation of the G protein-coupled receptor LGR5 and receptor tyrosine kinase ERBB3 during ER stress in cancer cells.
J. Biol. Chem., in press (2020)
2020年2月12日
Miyazaki, K., Ichikawa, Y., Saitoh, N. and Saitoh, H.
Three types of nuclear envelope assemblies associated with micronuclei.
CellBio, in press (2020)
2020年2月7日
Loo, T. M., Miyata, K., Tanaka, Y. and Takahashi, A.
Cellular senescence and senescence-associated secretory phenotype via the cGAS-STING signaling pathway in cancer.
Cancer Sci., 111, 304-311 (2020)
2020年2月3日
Tanaka, M., Homme, M., Yamazaki, Y., Ae, K., Matsumoto, S., Subramanian, S. and Nakamura, T.
Cooperation between SS18-SSX1 and miR-214 in synovial sarcoma development and progression.
Cancers, 12, 324 (2020)
2020年1月21日
Kawakami, R., Mashima, T., Kawata, N., Kumagai, K., Migita, T., Sano, T., Mizunuma, N., Yamaguchi, K. and Seimiya, H.
ALDH1A3‐mTOR axis as a therapeutic target for anticancer drug‐tolerant persister cells in gastric cancer.
Cancer Sci., in press (2020)
2020年1月21日
Takahashi, K., Seto, Y., Okada, K., Uematsu, S., Uchibori, K., Tsukahara, M., Oh-hara, T., Fujita, N., Yanagitani, N., Nishio, M., Okubo, K. and Katayama, R.
Overcoming resistance by ALK compound mutation (I1171S + G1269A) after sequential treatment of multiple ALK inhibitors in non-small cell lung cancer.
Thorac. Cancer, in press (2020)
2020年1月7日
Jang, M. K., Mashima, T. and Seimiya, H.
Tankyrase inhibitors target colorectal cancer stem cells via AXIN-dependent downregulation of c-KIT tyrosine kinase.
Mol. Cancer Ther., in press (2020)
2020年1月6日
Tanaka, N., Takahara, A., Hagio, T., Nishiko, R., Kanayama, J., Gotoh, O. and Mori, S.
Sequencing artifacts derived from a library preparation method using enzymatic fragmentation.
PLoS One, 15, e0227427 (2020)

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