1. How chromosomes are assembled in mitosis?
  2. How kinetochore-microtubule attachment is controlled?
  3. How do cells induce chromosome segregation at the correct time?
  4. Mechanisms of chromosomal instability in cancer cells

Mechanisms of chromosome instability in cancer cells

Many malignant tumors are aneuploid, and reveal high rates of chromosome segregation defects as cells devide. This genetic heterogeneity is thought to contribute to malignant phenotypes. Studies into the basic mechanisms of chromosome segregation have revealed many pathways that might cause chromosomal instability. Based on our knowledge about the physiological regulation of mitosis, we are now ready to characterize chromosome dynamics in cancer cells, in order to investigate the ´lesion´ in chromosome segregation machinery. These approaches should lead to improved treatments for cancer.

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