| 2026年8月6日 |
Sasaki, N., Suezawa, T., Kitano, S., Katayama, R. and Matsusaki, M. Hierarchical collagen nanofiber gels recapitulate a physiologically relevant tumor stromal microenvironment.
Adv. Healthc. Mater., e00877 (2026) |
| 2026年8月6日 |
Sakahara, M., Okamoto, T., Kumegawa, K., Natsume, Y., Kusama, D., Yamanaka, H., Komatsuzaki, R., Yaginuma, K., Srivastava, U., Takahashi-Kanemitsu, A., Susaki, E. A., Obama, K., Nagayama, S., Maruyama, R. and Yao, R. Colorectal cancer co-opts an epidermal wound healing program during metastasis to generate disseminated tumor cells.
Nat. Commun., in press (2026) |
| 2026年8月3日 |
Noda, T., Shirahama, H., Tani, Y. and Tomida, A. Pharmacological blockade of oncogenic MAPK activators drives resistance to cystine deprivation with lipid redox remodeling.
Biochem. Biophys. Res. Commun., 832, 154376 (2026) |
| 2026年7月14日 |
Yoshitake, H., Negoto, T., Moritsubo, M., Furuta, T., Jo, M., Hirota, T., Sakata, K., Nakamura, H. and Morioka, M. Chromosomal instability is associated with paradoxical cGAS upregulation and impaired STING signaling shaping the immune microenvironment in glioblastoma.
Neurooncol. Adv., vdag179 (2026) |
| 2026年6月23日 |
Hara, T., Meng, S., Konno, M., Nishida, N., Koseki, J., Meguro, K., Kawano, Y., Morie, T., Dan, S., Satoh, T., Akai, S., Tsujikawa, K., Eguchi, H., Mori, M., Miura, Y., Nishiyama, N. and Ishii, H. Identification of novel small-molecule inhibitors targeting KDM5B and evaluation of their antitumour effects.
Cancer Med., 15, e72058 (2026) |
| 2026年6月19日 |
Ozaki, H., Sasaki, N. and Kitajima, S. An aminoacyl-tRNA synthetase governs dsRNA-mediated trade-off between longevity and innate immunity.
Mol. Cell, 86, 2237-2239 (2026) |
| 2026年6月15日 |
Kamakura, N., Jo, M., Takahashi, M. and Hirota, T. Targeting cell cycle vulnerabilities in cancers: Emerging strategies for therapeutic development.
Cancer Sci., in press (2026) |
| 2026年6月5日 |
Tanaka, T., Fujitani, M., Taoka, M., Shimomura, I., Okawa, S., Mori, S., Kuribayashi, T., Nishimura, J., Nishimura, T., Morita, A., Hara, N., Ninomiya, K., Makimoto, G., Higo, H., Rai, K., Ichihara, E., Tomida, S., Hotta, K., Togashi, Y., Maeda, Y., Kiura, K., Katayama, R. and Ohashi, K. Afatinib overcomes osimertinib resistance via Egfr v804f mutation in a syngeneic Egfr-mutant lung cancer mouse model.
Cancer Sci., in press (2026) |
| 2026年5月22日 |
Nagasaka, M., Facchinetti, F., Bigot, L., Brayé, F., Groves, M. R., Yosa, J., Wekken, A. V., Aldea, M., Besse, B., Planchard, D., Naltet, C., Katayama, R., Olaussen, K. A., Loriot, Y. and Friboulet, L. The novel ALK K1150dup mutation mediates resistance to frontline lorlatinib and retains sensitivity to gilteritinib.
npj Precis. Oncol., in press (2026) |
| 2026年5月22日 |
Kurosaki, T., Suzuki, S., Watanabe, Y., Kenmotsu, H., Itoh, S., Yamaguchi, M., Shiono, A., Suzuki, T., Yokoyama, T., Toi, Y., Tanaka, H., Oki, M., Tsuda, T., Ichihara, E., Azuma, K., Tanaka, H., Arai, R., Uchibori, K., Miyauchi, E., Katayama, R. and Hayashi, H. Immune-related gene expression profiling and alectinib efficacy for patients with ALK-rearranged non-small cell lung cancer: exploratory analysis of a prospective observational study.
Lung Cancer, 216, 109416 (2026) |
| 2026年5月22日 |
Nishimura, J., Kuribayashi, T., Brägelmann, J., Okawa, S., Taoka, M., Mori, S., Nishimura, T., Tanaka, T., Makimoto, G., Ninomiya, K., Rai, K., Ichihara, E., Katayama, R., Hotta, K., Tabata, M., Togashi, Y., Maeda, Y., Sos, M. L., Kiura, K. and Ohashi, K. Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr-mutated lung cancer.
Mol. Oncol., in press (2026)
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| 2026年4月30日 |
Yoshida, S. Y., Matsumoto, K., Takagi, S., Kinoshita, F. L., Yamashita, K., Shigeta, D., Yoshioka, Y., Ushiku, T., Morii, E., Susaki, E. A. and Ueda, H. R. Whole-organ and whole-body 3D atlases enable cellome-wide profiling.
Cell, 189, 1836-1853.E19 (2026)
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| 2026年4月27日 |
Seshimo, N., Hori, K., Furuta, R., Hirota, T. and Nozawa, R. S. High-risk HPV E6 induces an aneuploidy-prone chromosome congression defect through destabilization of CENP-E.
J. Virol., 100, e0062526 (2026)
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| 2026年4月20日 |
Suenaga, M., Mashima, T., Kawata, N., Dan, S., Seimiya, H. and Yamaguchi, K. Preclinical identification and clinical validation of dynamic biomarkers for trifluridine/tipiracil with or without bevacizumab in metastatic colorectal cancer.
ESMO Gastrointest. Oncol., 12, 100323 (2026) |
| 2026年4月17日 |
Hakozaki, Y., Sugimoto, K., Yamada, Y., Danno, T., Hashimoto, K., Shinchi, H., Kume, H. and Ueda, K. Proteogenomic detection of tumor-specific somatic mutant proteins in urinary extracellular vesicles for non-invasive monitoring of bladder cancer.
Front. Oncol., 16, 1808671 (2026)
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| 2026年4月13日 |
Kawamoto, S., Horiguchi, H., Torigoe, D., Wakita, M., Ito, K., Sugawara, S., Zhou, X., Mikawa, T., Park, J. H., Jung, B. K., Okumura, Y., Miyagawa, H., Maruya, M., Hori, N., Uemura, K., Sugimoto, M., Matsuda, M., Mochizuki, N., Kondoh, H., Takahashi, A., Oike, Y. and Hara, E. Reevaluating the senolytic activity of a GLS1 inhibitor and an anti-PD-1 antibody: toward greater reproducibility and methodological rigor.
EMBO Rep., in press (2026) |
| 2026年4月2日 |
Sakiyama, K., Kumegawa, K., Yang, L., Tanabe, M. and Maruyama, R. Long-term intermittent estradiol exposure induces epithelial-mesenchymal transition-like plasticity in MCF10A cells.
Biochem. Biophys. Res. Commun., 812, 153601 (2026) |
| 2026年4月2日 |
Shirouchi, Y., Shinchi, H., Haga, Y., Mishima, Y., Minowa, S., Takayama, T., Takahashi, S., Maruyama, D. and Ueda, K. Extracellular vesicle IL5RA and BCMA in serum enable non-invasive risk stratification of multiple myeloma.
Cancers, 18, 1116 (2026) |
| 2026年3月10日 |
Bernardi, F., Torrejon, J., Basili, I., Van Ommeren, R., Marsaud, V., Yu, H., Talbot, J., Souphron, J., Indersie, E., Forget, A., Bonneau, B., Massiot, A., Alcazar, C., Figeac, L., Bonerandi, E., Cancila, G., Sirbu, O., Yadav, N., Mohanakrishnan, D., Lombard, B., Loew, D., Poullet, P., Liva, S., Lovino, M., Lin, I. H., Nakashima, T., Gharsalli, T., Nicolas, P. A., Yubuki, N., Ribas, R. A., Colsch, B., Chu-Van, E., Castelli, F., Sampaio, J. L., Leboucher, S., Lasgi, C., Besse, L., Soler, M. N., Lo Re, V., Planque, N., Abeysundara, N., Balin, P., Wang, H., Su, H., Wu, X., Cavalli, F. M. G., Saulnier, O., Ficarra, E., Di Marcotullio, L., Kumegawa, K., Maruyama, R., Kawauchi, D., Picard, D., Remke, M., Riffaud, L., Puiseux, C., Bouchoucha, Y., Huybrechts, S., Simbozel, M., Bourdeaut, F., Varlet, P., Puget, S., Blauwblomme, T., Andrianteranagna, M., Planchon, J. M., Dugourd, A., Saez-Rodriguez, J., Barillot, E., Servant, N., Martignetti, L., Rich, J., Kool, M., Pfister, S. M., Agnihotri, S., Suzuki, H., Fanjul, M., Wang, W. J., Tsai, J. W., Sun, R. C., Beccaria, K., Dufour, C., Sarry, J. E., Michealraj, K. A., Taylor, M. D. and Ayrault, O. Multiomic integration reveals tumoral heterogeneity of lipid dependence within lethal group 3 medulloblastoma.
Cancer Cell, 44, 383-404.e18 (2026) |
| 2026年3月10日 |
Miyatake, Y., Kamakura, T., Ikawa, T., Yanagiya, R., Kotaki, R., Kameda, K., Nasu, R. K., Okuyama, K., Hirano, K. I., Hosokawa, H., Hozumi, K., Ohtsuka, M., Kisikawa, T., Shibata, C., Otsuka, M., Maruyama, R., Ando, K., Kurosaki, T., Kawamoto, H. and Kotani, A. A single microRNA miR-195 rescues the arrested B cell development induced by EBF1 deficiency.
eLife, 13, RP101510 (2026) |
| 2026年3月10日 |
Furukawa, T., Kumegawa, K., Miyata, K., Takamatsu, M., Iesato, A., Saeki, S., Yang, L., Shibata, C., Takahara, T., Masuda, K., Mie, T., Okamoto, T., Takeda, T., Sasaki, T., Ozaka, M., Tanaka, M., Takahashi, S., Noda, T., Yao, R., Sasahira, N. and Maruyama, R. Patient-derived orthotopic xenograft models recapitulate the peritoneal dissemination of pancreatic cancer and delineate its transcriptional and regulatory programs.
J. Exp. Clin. Cancer Res., in press (2026) |
| 2026年2月24日 |
Nakayama, C., Fang, Q., Daigaku, Y., Aoi, Y., Ito, S., Takahashi, M., Shimatani, R., Minamisawa, T., Ozturk, Y., Kimura, H., Shilatifard, A., Tellier, M. and Nojima, T. NELF prevents transcriptional readthrough into DNA replication zones in cancer cells.
EMBO Rep., in press (2026) |
| 2026年2月13日 |
Tanaka, Y., Sakahara, M., Yamanaka, H., Natsume, Y., Kusama, D., Kumegawa, K., Yoshikawa, H., Abe, Y., Okabayashi, K., Matui, S., Kitagawa, Y., Koshikawa, N., Osumi, H., Shinozaki, E., Nagayama, S., Adachi, J., Maruyama, R. and Yao, R. Ribosome biogenesis as a potential therapeutic target in KRAS mutant colorectal cancer.
Nat. Commun., 17, 1224 (2026) |
| 2026年2月9日 |
Thanongsak, W., Kawahara, M., Nakamoto, M., Homma, K., Sereemaspun, A., Tachaboonyakiat, W., Ruktanonchai, U., Yoshimoto, K., Katayama, R., Matsusaki, M. and Chirachanchai, S. Concerted pH-responsive performance of chitosan-deoxycholic acid as a polymeric molecular block for cancer cell disruption.
ChemMedChem, 21, e202500587 (2026) |
| 2026年2月9日 |
Izumi, H., Sakamoto, T., Uchibori, K., Nishino, K., Sakakibara-Konishi, J., Katayama, R., Nomura, S., Matsumoto, S., Udagawa, H., Shibata, Y., Sakai, T., Nosaki, K., Zenke, Y., Yoh, K., Niho, S. and Goto, K. Phase 1/2 trial of brigatinib plus panitumumab in patients with osimertinib-resistant EGFR-mutated non-small cell lung cancer harboring EGFR C797S mutation.
Cancer Treat. Res. Commun., 46, 101105 (2026) |
| 2026年1月30日 |
Wakita, M., Ito, K., Fujii, K., Sakamoto, D., Mikawa, T., Sugawara, S., Zhou, X., Park, J. H., Miyagawa, H., Motooka, D., Ogasawara, E., Ishihara, N., Takahashi, A., Kondoh, H. and Hara, E. Comparative analysis of senolytic drugs reveals mitochondrial determinants of efficacy and resistance.
Nature aging, in press (2026) |
| 2026年1月13日 |
Moroishi, K., Nakamoto, M., Fujita, S., Kawahara, M., Katayama, R. and Matsusaki, M. Escape from cell uptake: Drug-free cancer therapeutics regulated by hydrophobicity and negative charge.
Mater. Today Bio, 102752 (2025) |
| 2026年1月13日 |
Fu, J., Kamiya, K., Kitamura, K., Kawahara, R., Shihoya, W., Nureki, O., Hosoya, S., Nakagawa, R., Mashima, T., Itoh, H., Inoue, M. and Sakurai, K. Photoaffinity labeling strategy reveals tetraspanin CD9 as a transient target of anticancer Yaku’amide B.
J. Am. Chem. Soc., 148, 2985-2994 (2026) |
| 2026年1月5日 |
Otsuka, M., Okamoto, Y., Hasebe, A., Shirahama, H. and Tomida, A. HER3 enhances ATF4 induction and survival in breast cancer cells during endoplasmic reticulum stress.
Biochem. Biophys. Res. Commun., 797, 153215 (2026) |
| 2026年1月5日 |
Yokomura, M., Nagano, S., Kawamoto, H., Hirohashi, Y., Torigoe, T., Asakage, T. and Katayama, R. Afatinib exerts an inhibitory effect on T cell-mediated cytotoxicity.
Cancer Immunol. Immunother., 75, 33 (2026) |
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